Management of bone defects using the Masquelet technique of induced membrane

Debnar, M; Kopp, L; Mišičko, R

doi:10.33699/pis.2021.100.8.390-397

Cited by 3 publications

(4 citation statements)

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“…Infection has a great influence on bone healing, especially in the treatment of large bone defects. 40 Our analysis suggests that post‐procedural bone graft infections only occurred in patients with infected nonunion. Logically, patients undergoing IMT for infected nonunion were much more likely to sustain post‐procedural bone graft infections.…”

Section: Discussionmentioning

confidence: 72%

“…Bone graft supplementation is a critical step in treating nonunion, especially in procedures involving the IMT. 40 , 47 Recently, non‐autologous bone grafts, such as allografts, xenografts, and synthetic and bone substitutes, as well as bone morphogenetic protein, have been widely utilized in the IMT. 40 , 48 According to Pesciallo et al ., a proportion of allograft usage does not affect the final union and failure rates of the IMT.…”

Section: Discussionmentioning

confidence: 99%

“… 40 , 47 Recently, non‐autologous bone grafts, such as allografts, xenografts, and synthetic and bone substitutes, as well as bone morphogenetic protein, have been widely utilized in the IMT. 40 , 48 According to Pesciallo et al ., a proportion of allograft usage does not affect the final union and failure rates of the IMT. 28 However, autografts are believed to possess superior mechanical and biological properties compared with allogeneic or synthetic bone substitutes—owing to the osteogenic properties of osteoinduction and osteoconduction.…”

Section: Discussionmentioning

confidence: 99%

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Induced Membrane Technique for the Management of Segmental Femoral Defects: A Systematic Review and Meta‐Analysis of Individual Participant Data

Lai

et al. 2022

Orthopaedic Surgery

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Several modifications of the induced membrane technique (IMT) have been reported, but there is no consensus regarding their results and prognosis. Moreover, most studies have focused on tibial defects; no meta‐analysis of the treatment of femoral defects using the IMT has been reported. This systematic review and meta‐analysis aimed to identify the potential risk factors of post‐procedural complications following the treatment of segmental femoral defects using the IMT. A comprehensive search was performed on the Cochrane Library, EBSCO, EMBASE, Ovid, PubMed, Scopus, and Web of Science databases, using the keywords “femur,” “Masquelet technique,” and “induced membrane technique.” Original articles composed in English, having accessible individual patient data, and reporting more than two cases of bony defect or nonunion of femur or more than five cases of any body part were included. Post‐procedural bone graft infections, final union status, and union time after second‐stage operation were analyzed. Fourteen reports, including 90 patients, were used in this study. External fixation in second‐stage surgery had an odds ratio of 9.267 for post‐procedural bone graft infection (p = 0.047). The odds ratio of post‐procedural bone graft infection and age >65 years for final non‐union status was 51.05 (p = 0.003) and 9.18 (p = 0.042). Shorter union time was related to impregnated antibiotics in the spacer (p = 0.005), transplanting all‐autologous grafts (p = 0.042), and the application of intramedullary nails as the second‐stage fixation method (p = 0.050). The IMT appears to be reasonable and reproducible for femoral segmental bone defects. Several preoperative and surgical factors may affect post‐procedural complications and union time.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Induced Membrane Technique for the Management of Segmental Femoral Defects: A Systematic Review and Meta‐Analysis of Individual Participant Data

Lai

et al. 2022

Orthopaedic Surgery

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“…IBD can cause systemic infections and endanger patients’ lives, thereby increasing the difficulty of healing. 8 …”

Section: Introductionmentioning

confidence: 99%

The Antibacterial Effect, Biocompatibility, and Osteogenesis of Vancomycin-Nanodiamond Composite Scaffold for Infected Bone Defects

Chen¹,

Li²,

Hou³

et al. 2023

IJN

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Purpose The repair and treatment of infected bone defects (IBD) is a common challenge faced by orthopedic clinics, medical materials science, and tissue engineering. Methods Based on the treatment requirements of IBD, we utilized multidisciplinary knowledge from clinical medicine, medical materials science, and tissue engineering to construct a high-efficiency vancomycin sustained-release system with nanodiamond (ND) and prepare a composite scaffold. Its effect on IBD treatment was assessed from materials, cytology, bacteriology, and zoology perspectives. Results The results demonstrated that the Van-ND-45S5 scaffold exhibited an excellent antibacterial effect, biocompatibility, and osteogenesis in vitro. Moreover, an efficient animal model of IBD was established, and a Van-ND-45S5 scaffold was implanted into the IBD. Radiographic and histological analyses and bone repair-related protein expression, confirmed that the Van-ND-45S5 scaffold had good biocompatibility and osteogenic and anti-infective activities in vivo. Conclusion Collectively, our findings support that the Van-ND-45S5 scaffold is a promising new material and approach for treating IBD with good antibacterial effects, biocompatibility, and osteogenesis.

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Semi-focal bone transport versus traditional bone transport technique for the management of large tibial bone defects after trauma

Wang,

Ma,

et al. 2024

Sci Rep

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How to deal with large tibial bone defects is still controversial. The purpose of this research was to compare the semi-focal bone transport (SFBT) technique with traditional bone transport (TBT) technique for treating such patients. Sixty-two patients were included and retrospectively analyzed. In all cases, after radical debridement large tibial bone defects remained. Patients were treated by the SFBT or TBT technique. The distraction, consolidation duration and complications were recorded by the patients’ medical files. Based on the Association for the Study and Application of Methods of Ilizarov (ASAMI) standard, the bone and functional results were evaluated. The mean bone defect size was 7.7 ± 1.6 cm and 7.5 ± 2.1 cm for SFBT and TBT patients. The mean external fixation index (EFI) was 1.51 ± 0.14 months/cm and 1.89 ± 0.25 months/cm for SFBT and TBT patients (p < 0.05), respectively. With respect to bone and function results, there was no significant differences between the two groups (p > 0.05). The mean number of complications per patient was 1.1 ± 0.6 and 1.6 ± 0.7 for SFBT and TBT patients (p < 0.05). Compared to the traditional bone transport technique, patients using the semi-focal bone transport technique achieved better clinical effects, including shorter EFI and less complications. Therefore, the SFBT technique could be a new option for patients with large tibial bone defects.

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Management of bone defects using the Masquelet technique of induced membrane

Cited by 3 publications

References 0 publications

Induced Membrane Technique for the Management of Segmental Femoral Defects: A Systematic Review and Meta‐Analysis of Individual Participant Data

Induced Membrane Technique for the Management of Segmental Femoral Defects: A Systematic Review and Meta‐Analysis of Individual Participant Data

The Antibacterial Effect, Biocompatibility, and Osteogenesis of Vancomycin-Nanodiamond Composite Scaffold for Infected Bone Defects

Semi-focal bone transport versus traditional bone transport technique for the management of large tibial bone defects after trauma

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