Management of Marjolin's ulcer in a chronic pressure sore secondary to paraplegia: a radical surgical solution

Fairbairn, Neil; Hamilton, Stuart A.

doi:10.1111/j.1742-481x.2011.00831.x

Cited by 24 publications

(31 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, there is a consensus on the importance of chronic irritation. Repeated ulceration to the scar and subsequent initiation of re-epithelialization provides a prolonged stimulus for cellular proliferation and may increase the rate of spontaneous mutations [17,19,20]. …”

Section: Discussionmentioning

confidence: 99%

Marjolin’s ulcer: a preventable malignancy arising from scars

Long

Lujan-Hernandez

et al. 2013

World J Surg Onc

View full text Add to dashboard Cite

BackgroundMarjolin’s ulcer (MU) is a rare malignancy arising from various forms of scars. This potentially fatal complication typically occurs after a certain latency period. This article attempts to reveal the importance of the latency period in the prevention and early treatment of the malignancy.MethodsA retrospective review of 17 MU patients who underwent surgical procedures between June of 2005 and December 2011 was conducted. Etiology of injuries, latency period, repeated ulceration, and outcomes were recorded. This observational report reveals characteristics of patients who develop MU.ResultsAn incidence of 0.7% of MU was found amongst patients complaining of existing scars in our study; burns and trauma were the most common etiology of MU. The mean latency period was 29 years (SD = 19) and the mean post-ulceration period was 7 years (SD = 9). Statistical analysis revealed a negative correlation between the age of patients at injury and the length of latency period (r = −0.8, P <0.01), as well as the lengths of pre-ulceration and post-ulceration periods (r = −0.7, P <0.01).ConclusionsPatients experience different lengths of pre- and post-ulceration periods during the latency period. Younger patients tend to have a longer latency period. Skin breakdown on chronic scars and chronic unhealed ulcers are two main sources of MU. MU may be preventable with a close surveillance of the ulcer during the latency period.

show abstract

Section: Discussionmentioning

confidence: 99%

Marjolin’s ulcer: a preventable malignancy arising from scars

Long

Lujan-Hernandez

et al. 2013

World J Surg Onc

View full text Add to dashboard Cite

show abstract

“…The transformation from ulcer to malignancy is typically slow and the pathogenesis is unclear, 5,6 but it is most likely multifactorial. 7 Chronic foreign body induced inflammation from retained shrapnel fragments appears to be the cause in our patient's case.…”

Section: Discussionmentioning

confidence: 56%

Old War Scar Revisited

Wozniak

Zuo

Khan

et al. 2015

Journal of the American College of Clinical Wound Specialists

View full text Add to dashboard Cite

In 1828, Jean Nicholas Marjolin, a French surgeon, first described the findings of a neoplastic development arising from a burn scar, now more commonly referred to as a Marjolin's ulcer. A Marjolin's ulcer describes malignant degeneration in any chronic wound. The majority of cases arises in burn scars and are often latent for decades. Marjolin ulcers have been widely identified in post-war time injuries. These ulcers may arise in almost any anatomical location. We report a case of an 82-year-old male that presented with a painful fluctuating mass on the right arm localized to the site of an old grenade blast injury he sustained many years earlier. While the presentation of these cases may be variable, the significance of proper management of the wounds is essential to optimal patient outcomes. An aggressive course and poor prognosis is associated with Marjolin's ulcers that degenerate into squamous cell carcinoma. Early detection and aggressive treatment/management with wide local excision and prompt coverage yield the best results when treating patients with Marjolin's ulcers.

show abstract

“…From the physical examination, the classic triage is obtained, which is formation of nodules, induration and ulceration at the scar location. In addition, also found wounds with edging edges, excess granulation tissue, unpleasant odor, enlargement, bleeding and pain [16], [20], [21], [22].…”

Section: Discussionmentioning

confidence: 99%

“…There are some pathophysiology theories of Marjolin's ulcer's, among them said that it is caused by mutagenic accumulation with mitotic activities aimed for regeneration, production of carcinogenic toxins by scar tissue, inadequate immunological reactions in scarring areas, chronic irritation, recurrent trauma and possible DNA damage in the area [1], [6]- [8], [16], [21].…”

Section: Discussionmentioning

confidence: 99%

Acral Lentiginous Melanoma, Rare Form of Marjolin?s Ulcer: A Case and Literature Review

2017

IJSR

View full text Add to dashboard Cite

Marjolin's ulcer is a cutaneous malignancy that previously traumatized and chronically inflammed. The incidence of Marjolin's ulcer in acral lentiginous melanoma form is extremely low. We report the first Marjolin's ulcer in our hospital, which developed from chronic wound 20 years after traumatic injury. Wide local excision was performed and it was diagnosed histopathologically as acral lentiginous melanoma.

show abstract

Management of Marjolin's ulcer in a chronic pressure sore secondary to paraplegia: a radical surgical solution

Cited by 24 publications

References 18 publications

Marjolin’s ulcer: a preventable malignancy arising from scars

Marjolin’s ulcer: a preventable malignancy arising from scars

Old War Scar Revisited

Acral Lentiginous Melanoma, Rare Form of Marjolin?s Ulcer: A Case and Literature Review

Contact Info

Product

Resources

About