Management of Severe Anogenital Acne Inversa (Hidradenitis Suppurativa)

Wollina, Uwe; Tilp, Michaela; Meseg, Antje; Schönlebe, Jaqueline; Heinig, Birgit; Nowak, Andreas

doi:10.1111/j.1524-4725.2011.02157.x

Cited by 32 publications

(46 citation statements)

References 29 publications

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“…Wollina et al [138] analyzed the records of patients with anogenital HS from 2000 to 2010 to evaluate the role of surgery in the treatment of severe anogenital HS, and they concluded that surgery is the cornerstone of treatment for advanced forms of HS, and they underlined the importance of secondary intention healing. Watson [139] noted the need for reoperation in approximately 20% of patients with inguinal disease whether they were treated with excision and primary closure or excision and skin grafting.…”

Section: Reconstruction After Radical Wide Excisionmentioning

confidence: 99%

Medical and Surgical Treatment of Hidradenitis Suppurativa: A Review

Scuderi

Monfrecola

Dessy

et al. 2017

Skin Appendage Disord

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Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with painful nodules, abscesses, sinus tracts, and scarring primarily affecting apocrine gland-rich intertriginous areas. HS prevalence ranges from 0.05 to 1%. The central pathogenic event in HS is believed to be the occlusion of the upper part of the folliculopilosebaceous unit, leading to the rupture of the sebofollicular canal with the consequent development of perifollicular lymphohistiocytic inflammation. The HS treatment choices are influenced by disease severity and its individual subjective impact, involving both medical and surgical interventions. However, given the chronic nature of HS, its destructive impact on social, working, and daily life of patients, its management is often frustrating for both the patient and physician. Hence, prompt and effective management strategies are urgently needed and a multidisciplinary approach is advocated. Therefore, in this article, we highlighted the main features of HS (clinical aspects, epidemiology, pathogenesis, diagnostic criteria, classifications, comorbidities, and treatments), so that awareness of this disease might be heightened in primary care physicians and surgeons, who may be the first health care providers to see patients with this disease owing to its characteristic clinical presentation (inflammatory nodules, abscesses, sinus tract, etc.).

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Section: Reconstruction After Radical Wide Excisionmentioning

confidence: 99%

Medical and Surgical Treatment of Hidradenitis Suppurativa: A Review

Scuderi

Monfrecola

Dessy

et al. 2017

Skin Appendage Disord

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“…The quality of pain described by patients was hot, burning, pressure, cutting, sharp, taut, splitting, gnawing, sore, throbbing, and aching to sometime during their disease or as a chronic symptom in others. [32]…”

Section: Introductionmentioning

confidence: 99%

“…[3263–65] In rare cases, however, etanercept can induce AI. [66] In a meta-analysis, 65 studies including 459 patients on TNFαI were evaluated.…”

Section: Introductionmentioning

confidence: 99%

“…[3295–97] Abscess pain relief is a symptomatic treatment. It has no effect on the further course of the disease.…”

Section: Introductionmentioning

confidence: 99%

“…Granulation can be stimulated by the use of topical CO2 application. [32] In a study with 56 AI patients, wide surgical excision was performed. Healing by second intention was the choice in 32 (57.1%) patients, and 24 (42.9%) patients underwent delayed skin-grafting.…”

Section: Introductionmentioning

confidence: 99%

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Acne inversa (Hidradenitis suppurativa): A review with a focus on pathogenesis and treatment

Wollina

Koch

Heinig

et al. 2013

Indian Dermatol Online J

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Acne inversa (AI) is a disabilitating chronic inflammatory disease with major negative impact on quality of life and significant co-morbidities. This is an important link to insights into immune dysfunction, which stimulated therapeutic approaches like tumor necrosis-α inhibitor therapy. This new off-label drug treatment is particularly beneficial when used in combination with wide excision of inflamed skin and subcutaneous tissue. Retinoids have been reported to be helpful in secondary prevention. The standard of therapy in advanced cases is surgery with wide excisions and healing by secondary intention. This treatment results in significant reduction of complaints and achieves satisfactory body contouring.

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