Management of the Lymph Nodes in Penile Cancer

Heyns, Chris F.; Fleshner, Neil; Sangar, Vijay K; Schlenker, Boris; Yuvaraja, T.; Poppel, Hendrik Van

doi:10.1016/j.urology.2010.03.001

Cited by 90 publications

(74 citation statements)

References 130 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Different treatments were performed in similar clinical settings. These facts reflect the lack of standardization of the treatment of penile cancer nowadays, particularly in relation to lymph node involvement (24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological study of penile cancer in Pernambuco: experience of two reference centers

et al. 2014

View full text Add to dashboard Cite

ARTICLE INFO ______________________________________________________________ ______________________Objectives: To investigate and analyze the epidemiological profile of penile cancer in the state of Pernambuco and compare this information with other studies related to the issue. Material and Methods:We conducted a retrospective, observational and descriptive study of all patients with penile cancer in two reference centers in Pernambuco -Brazil, from 2007 to 2012. The variables studied were: age, region from the state, socio--economic situation, previous postectomy, smoking, time from the beginning of injury to diagnosis, staging of the primary lesion, tumor differentiation, treatment performed and death due to cancer. Results:The total number of patients was 88. The highest prevalence was seen in those aged between 66 and 75 years. About the socio-economic situation, 67% worked informally and 64.8% received up to two minimum wages. Of all patients, 57% were married and 50% illiterate. The Metropolitan Region of Recife was the one with the highest number of cases, 41%. Tobacco smoking was reported in 48.9% of cases and prior postectomy in 3.4%. Most often it was observed an average period of six months from the onset of symptoms to diagnosis. And when the lesion was diagnosed, it usually had 2 to 5 cm (64.7%), stage T2 in 50% and well differentiated in 79.6%. Partial penectomy was performed in 76.1% and total in 17%. Death was observed in 27.3%. Conclusion:The clinical profile and epidemiological characteristics found in this study are similar to other national and international studies related to the issue, i.e., typical of underdeveloped or developing countries.

show abstract

Section: Discussionmentioning

confidence: 99%

Epidemiological study of penile cancer in Pernambuco: experience of two reference centers

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In half of these men, the adenopathy is related to metastatic disease. 31 The evidence for lymph node management was recently reviewed 32 and showed that clinically abnormal lymph nodes may require a different management strategy than those that are clinically negative.…”

Section: Clinical Uninvolved Lymph Nodesmentioning

confidence: 99%

“…40 Repeat biopsy is advised when the FNA is negative and the clinical suspicion is high. 41 A prolonged trial of antibiotics is no longer considered appropriate.…”

Section: Clinically Involved Lymph Nodesmentioning

confidence: 99%

“…58 If the sentinel lymph node biopsy is positive, ipsilateral therapeutic, radical inguinal lymph node dissection should be performed. 31,32,34 Early inguinal lymph node dissection in men with clinically negative nodes, but at high risk for nodal involvement, significantly improves cancer-specific survival and can be curative in 20% to 60% of histologically node-positive patients. 34 However, even in node-negative men, inguinal lymph node dissection does not guarantee survival, with a 5-year recurrence-free rate of 75% to 95%.…”

Section: Clinically Uninvolved Lymph Nodesmentioning

confidence: 99%

“…The presence of T2G2 or T2-3 G3 disease predicts lymph node involvement in up to 81% of cases. 40 More recently, disease ≥T1G3 has been considered high-risk disease. 5 Predictions based on histologic criteria alone, however, are not highly reliable.…”

Section: Clinically Uninvolved Lymph Nodesmentioning

confidence: 99%

See 2 more Smart Citations

Management of carcinoma of the penis: Consensus statement from the Canadian Association of Genitourinary Medical Oncologists (CAGMO)

Richter

Ruether

Wood

et al. 2013

CUAJ

Self Cite

View full text Add to dashboard Cite

Penis

Crook¹,

Pagliaro²,

Pettaway³

2017

TNM Online

View full text Add to dashboard Cite

Summary Cancer of the penis is an uncommon malignancy with an incidence in the developed world of about 1 per 100,000 men. There is considerable geographical variation in incidence. Established risk factors include oncogenic HPV types 16 and 18, tobacco consumption, phimosis and increasing age. It most commonly occurs on the glans and foreskin and in early stages is highly curable by local management. Penile preserving options, both surgical and radiotherapeutic, are emphasized. First line of spread is to regional lymph nodes, evaluation of which is essential for high‐risk tumours. For locally‐advanced presentations, a multidisciplinary approach is recommended, combining surgery, radiation and chemotherapy, the optimal sequencing of which is being explored in international cooperative clinical trials.

show abstract

Management of the Lymph Nodes in Penile Cancer

Cited by 90 publications

References 130 publications

Epidemiological study of penile cancer in Pernambuco: experience of two reference centers

Epidemiological study of penile cancer in Pernambuco: experience of two reference centers

Management of carcinoma of the penis: Consensus statement from the Canadian Association of Genitourinary Medical Oncologists (CAGMO)

Penis

Contact Info

Product

Resources

About