Polypharmacy in psychiatry is an in-depth examination of drug-drug interactions and treatment challenges
that explores the intricate landscape of psychiatric polypharmacy, a practice involving the prescription
of multiple medications to individuals with mental health disorders. This review is based on the critical aspects
of drug-drug interactions and the associated treatment challenges. Psychiatric polypharmacy is motivated
by the complexity of mental health conditions, where monotherapy may be insufficient. While it offers potential
benefits, the practice raises concerns related to drug interactions that can compromise safety and efficacy.
The review delves into the prevalence and clinical indications for psychiatric polypharmacy, thoroughly analyzing
drug interactions, treatment challenges, and strategies for mitigation. Real-world case studies illustrate
the complexities and outcomes of managing complex medication regimens, while emerging trends in personalized
medicine, advancements in psychopharmacology, multidisciplinary approaches, and digital health solutions
offer a glimpse into the future of psychiatric polypharmacy. This examination underscores the importance
of a patient-centered, evidence-based approach in optimizing psychiatric polypharmacy to achieve therapeutic
benefits while minimizing risks.