Managing a Patient with Presumed Testosterone-Secreting Ovarian Tumor

Lee, Wen-Ling; Wang, Peng-Hui; Tseng, Hsiuo-Shan; Lin, Hong-Da; Yuan, Chiou‐Chung; Chao, Hsiang‐Tai

doi:10.1006/gyno.1999.5507

Cited by 9 publications

(3 citation statements)

References 13 publications

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“…Wang et al demonstrated the effectiveness of GnRHa in a patient with SCT-NOS, whose elevated serum testosterone level after the complete tumor removal returned to normal after one cycle of GnRHa and was maintained for 32 months (Wang et al, 1998). Lee et al reported that elevated serum testosterone levels returned to normal after one cycle of GnRHa in a 70-year-old patient with presumed testosterone-secreting ovarian tumor (Lee et al, 1999). In our case, multiple measurable recurrent tumors were found and the administration of GnRHa successfully shrunk the tumor.…”

Section: Discussionmentioning

confidence: 99%

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Direct evidence on the efficacy of GnRH agonist in recurrent steroid cell tumor-not otherwise specified

Nakasone

Nakamoto

Matsuzaki

et al. 2019

Gynecologic Oncology Reports

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Background Steroid cell tumor (SCT) not otherwise specified (NOS) is rare and recurrence and metastasis rarely occurs; therefore, reports regarding its treatment are limited. We report a case of recurrent SCT-NOS treated with gonadotropin releasing hormone agonist (GnRHa) and successful. Case A 50-year-old woman underwent a staging laparotomy and diagnosed as SCT-NOS. Multiple liver tumors and intraperitoneal dissemination were detected 5 years 10 months after the initial surgery. As the immunohistochemical analysis showed positive staining for GnRH receptor, GnRHa was attempted. After the first cycle the serum testosterone level was normalized and after six cycles CT scan confirmed reduction of the tumor size. Conclusion Some ovarian SCT-NOS have GnRH receptors; thus, GnRHa may have a reducing effect for these tumors without major adverse event.

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Section: Discussionmentioning

confidence: 99%

“…As the immunohistochemical analysis of her primary tumor showed positive staining for GnRH receptor in the cytoplasm (Fig. 1), a GnRHa was attempted with reference to the previous case reports (Brewer and Shevlin, 1998; Wang et al, 1998; Lee et al, 1999) due to the lack of other effective alternatives after obtaining a written informed consent.…”

Section: Casementioning

confidence: 99%

Direct evidence on the efficacy of GnRH agonist in recurrent steroid cell tumor-not otherwise specified

Nakasone

Nakamoto

Matsuzaki

et al. 2019

Gynecologic Oncology Reports

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show abstract

“…Bogdanou et al [11] reported similar case of ovarian luteoma. Lee et al [12] reported a 70-year-old woman with multiple comorbidities who presented with progressive hirsutism and bilateral temporal balding. Tumor survey only detected elevated testosterone and renal vein catheterization identified right ovarian androgen-secreting tumor.…”

Section: Discussionmentioning

confidence: 99%

Hyperandrogenism in a Postmenopausal Woman Secondary to Testosterone Secreting Ovarian Stromal Tumor with Acoustic Schwannoma

Gandrapu

Sundar

Phillips

2018

Case Reports in Endocrinology

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Androgen-secreting ovarian neoplasms are rare ovarian tumors that present with hirsutism and virilization which may manifest as severe alopecia, deepening of voice, and clitoromegaly. Most often, ovarian tumors are found to be very small or even undetectable. In such cases, bilateral salpingo-oophorectomy should be performed after ruling out other causes of high androgens. We present a 63-year-old postmenopausal woman with clinically and radiologically undetectable testosterone-secreting ovarian tumor, which was later on detected on biopsy.

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Diagnosis and Localization of Testosterone-Producing Ovarian Tumors: Imaging or Biochemical Evaluation

Wang¹,

Chao²,

Liu³

et al. 2001

Gynecologic Oncology

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Managing a Patient with Presumed Testosterone-Secreting Ovarian Tumor

Cited by 9 publications

References 13 publications

Direct evidence on the efficacy of GnRH agonist in recurrent steroid cell tumor-not otherwise specified

Direct evidence on the efficacy of GnRH agonist in recurrent steroid cell tumor-not otherwise specified

Hyperandrogenism in a Postmenopausal Woman Secondary to Testosterone Secreting Ovarian Stromal Tumor with Acoustic Schwannoma

Diagnosis and Localization of Testosterone-Producing Ovarian Tumors: Imaging or Biochemical Evaluation

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