Managing pathologic aggression in people with psychotic disorders

Bourget, Dominique; Labelle, Alain

doi:10.1503/jpn.110174

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…, 63 Additionally, whereas 5HT depletion increases aggressive behavior, increasing 5HT levels brings about increased activity in the PFC as well as diminished aggression 64 . This reduction in serotonergic activity observed in impulsively aggressive individuals is not found in patients with predatory aggression, which further supports the heterogeneic nature of violent behavior 23 57 The serotonin 5HT2A receptor in particular may be implicated in aggressive behavior: a recent study showed that availability of the 5HT2A receptor is greater in aggressive patients compared to non-aggressive patients or healthy controls 64 .…”

Section: Neurotransmitters and Violencementioning

confidence: 72%

“…64 This reduction in serotonergic activity observed in impulsively aggressive individuals is not found in patients with predatory aggression, which further supports the heterogeneic nature of violent behavior. 23,57 The serotonin 5HT2A receptor in particular may be implicated in aggressive behavior: a recent study showed that availability of the 5HT2A receptor is greater in aggressive patients compared to non-aggressive patients or healthy controls. 64 Contrary to the antiaggressive consequences of antagonism at 5HT2A receptors, agonism at 5HT2C receptors has also been shown to reduce impulsivity.…”

Section: Neurotransmitters and Violencementioning

confidence: 99%

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Deconstructing violence as a medical syndrome: mapping psychotic, impulsive, and predatory subtypes to malfunctioning brain circuits

Stahl¹

2014

CNS Spectr.

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Violence is a major management issue for forensic mental health systems. Violence can be approached as a medical syndrome and deconstructed into psychotic, impulsive, and predatory subtypes, which are hypothetically mapped onto corresponding malfunctioning brain circuits. Rational management of violence balances treatment with security, while targeting each subtype of violence with approaches unique to the psychotic, impulsive, and predatory forms of violence.

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Section: Neurotransmitters and Violencementioning

confidence: 72%

Section: Neurotransmitters and Violencementioning

confidence: 99%

Deconstructing violence as a medical syndrome: mapping psychotic, impulsive, and predatory subtypes to malfunctioning brain circuits

Stahl¹

2014

CNS Spectr.

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“…In the past 5 years, there have been numerous reviews of this topic, [94][95][96][97][98][99][100][101][102] and each highlights clozapine as a preferred treatment for psychosis associated with aggression. This confirms what was reported in earlier expert consensus guidelines.…”

Section: Specific Symptom Domains Recommendation 1: Aggression and Homentioning

confidence: 99%

Guidelines for the Pharmacotherapy of Schizophrenia in Adults

et al. 2017

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Objective: The present guidelines address the pharmacotherapy of schizophrenia in adults across different stages, phases, and symptom domains. Method: Guidelines were developed using the ADAPTE process, which takes advantage of existing guidelines. Six guidelines were identified for adaptation, with recommendations extracted from each. For those specific to the pharmacotherapy of schizophrenia in adults, a working group selected between guidelines and recommendations to create an adapted guideline. Results: Recommendations can be categorized into 6 areas that include 1) first-episode schizophrenia, 2) acute exacerbation, 3) relapse prevention and maintenance treatment, 4) treatment-resistant schizophrenia, 5) clozapine-resistant schizophrenia, and 6) specific symptom domains. For each category, recommendations are made based on the available evidence, which is discussed and linked to other established guidelines. Conclusions:In most cases, evidence-based recommendations are made that can be used to guide current clinical treatment and decision making. Notably, however, there is a paucity of established evidence to guide treatment decision making in the case of clozapine-resistant schizophrenia, a subsample that represents a sizable proportion of those with schizophrenia.

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The sociodemographic characteristics and psychiatric profiles of the accused persons who committed crime by means of firearms

Özdeş¹,

Oral²,

Cantürk³

et al. 2014

Anadolu Psikiyatri Derg

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Managing pathologic aggression in people with psychotic disorders

Abstract: The information in this column is not intended as a definitive treatment

Cited by 3 publications

References 25 publications

Deconstructing violence as a medical syndrome: mapping psychotic, impulsive, and predatory subtypes to malfunctioning brain circuits

Deconstructing violence as a medical syndrome: mapping psychotic, impulsive, and predatory subtypes to malfunctioning brain circuits

Guidelines for the Pharmacotherapy of Schizophrenia in Adults

The sociodemographic characteristics and psychiatric profiles of the accused persons who committed crime by means of firearms

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