Mandibular Reconstruction in a Patient With Rosai–Dorfman Disease

Ardila, Jorge Ernesto Cantini; Torres, Tulio; Torres, Carlos; Montealegre, Giovanni; García, Alejandra; Correa, Susana; Gómez-Ortega, Viviana

doi:10.1097/scs.0000000000002281

Cited by 1 publication

(2 citation statements)

References 14 publications

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“…4). Out of the 53 cases studied, 10 displayed unusual symptoms 24,25,33,34,36,43,44,52,53 . Specifically, the symptoms related to the eyes were observed in 5 studies 24,33,34,43,53 , while ear-related symptoms were observed in 3 studies 24,34,36 and paresthesia was seen only in 1 study 44 .…”

Section: Resultsmentioning

confidence: 99%

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Manifestations, Diagnosis and Treatment of Osseous Rosai-Dorfman Disease: A Systematic Review

Agarwal,

Abozeed

2023

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BACKGROUND We hypothesize that lymphadenopathy and extraosseous manifestation affect the management protocol and our aim is to aid in development of standardized diagnosis and treatment protocols. METHODS PubMed and Google Scholar were searched from January 2012 through December 2022 using keywords Rosai-Dorfman, Rosai and Dorfman, and bone. Out of 98 researches, meta-analysis of 51 full-text studies involving 53 individuals with osseous RDD was conducted. RESULTS A significant association was found between lymphadenopathy with steroid therapy (OR: 20.125, 95%CI: 3.02, 134.09, P=0.0004). Extraosseous RDD showed significant association with steroid therapy (P=0.0145), T1-isointense MRI (OR: 0.173, 95%CI: 0.0304, 0.986, P=0.035), T1-hyperintense MRI (OR: 0.16, 95%CI: 0.0314, 0.815, P=0.019) and T2-hyperintense MRI (OR: 0.115, 95%CI= 0.0206, 0.6456, P=0.007). CONCLUSION Osseous RDD is rare and lacks standardized diagnosis and treatment protocols. Patients with lymphadenopathy were 9 times more likely to receive steroids, and those with extraosseous manifestations were less likely to undergo MRI. RDD is often not initially considered in differential diagnoses, leading to worsened conditions. We propose that further testing is required in affected individuals to develop standardized protocols.

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Section: Resultsmentioning

confidence: 99%

“…Regarding the immunohistochemical analysis, out of the 29 studies, 5 11,13,36,52,58 showed a positive result for CD1a, while the rest were negative. Cyclin d1 levels were reported in only 2 studies, with Adam et.…”

Section: Resultsmentioning

confidence: 99%