“…The concept of an inter-uterine vascular event, whether it be causing embryonic hypoxia or producing a haematoma with indiscriminate damage of local cells, provides a particularly plausible explanation for the deformities of CM. The tentative proposition from McCarthy's first paper, and from others that followed, 30 36 Nagy et al 37 and Pluijmers et al 38 The search was made using PubMed and Embase, using the following terms: This resulted in only 28 articles where DO was applied during growth in patients with functional joints. There were six retrospective reviews, 39 two comparative studies, 40 two prospective studies, 41 three case reports, 42 one systematic review, 43 three reviews, 44 and one comment supporting a review.…”