Manganese superoxide dismutase is increased in the airways of smokers' lungs

Harju, Terttu; Kaarteenaho‐Wiik, Riitta; Sirviö, R; Pääkkö, Paavo; Crapo, James D.; Oury, Tim D.; Soini, Ylermi; Kinnula, Vuokko L.

doi:10.1183/09031936.04.00121203

Cited by 44 publications

(28 citation statements)

References 31 publications

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“…However, we found a dramatic increase in SOD and CAT activities among patients with more severe COPD. It was found that erythrocyte SOD and CAT activities gradually increased from GOLD stages I to IV in COPD patients, which is supported by previous reports [36][37][38][39][40][41]. Indeed, various studies [40][41][42] except one study [7] have suggested that certain markers of oxidative stress may be related to tobacco smoking or to the severity of COPD.…”

Section: Discussionsupporting

confidence: 76%

Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

Asimuddin

Gutta

Ansari³

et al. 2017

COPD Res Pract

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Background: Oxidative stress has been suggested in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD) with an additional burden of diabetes, hypertension and cardiovascular disease. In the present study, we investigated erythrocyte antioxidant enzymes activities in correlation to COPD severity and COPD comorbidities. Methods: One hundred twenty seven subjects with COPD and 59 healthy controls participated in this study. COPD severity was done based on the Global Initiative for Chronic Obstructive Lung Disease criteria. The erythrocytes enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and total antioxidant status (TAS) were measured with spectrophotometric method. Results: COPD patients showed significant decrease in TAS (p > 0.05), GST (p < 0.001) and GPx (p < 0.01) activities with progression of the disease. In patients, FEV 1 was negatively correlated with SOD, GR and positively correlated with GST and GPx activities. Further, multivariate logistic regression analysis revealed GST (OR = 0.93; 95% CI = -0.10 -0.01; p < 0.01) , GPx (OR = 0.98; 95% CI = -0.03 -0.00; p < 0.05) and TAS (OR = 0.95; 95% CI = -0.08 -0.00; p < 0.05) were independently associated with FEV 1 in GOLD stage IV and GST (OR = 1.11; 95% CI = 0.04-0.18; p < 0.001) in GOLD stage II. Regression analysis confirmed a significant difference in GPx activity in COPD -type 2 diabetes (OR = 0.04; 95% CI = -6.60 -0.53; P = 0.09), and GST activity in COPD -cardiovascular disease (OR = 2.51; 95% CI = 0.00 -1.84; p < 0.05) patients when compared to patients without comorbidities. Conclusion: A significant decline in lung function may be associated with altered antioxidant enzyme activity due to the strong correlation between GST and GPx with COPD severity. Our results also indicate that erythrocytes GST and GPX activities are significantly associated with comorbidities, but only in COPD patients with type 2 diabetes and cardiovascular disease.

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Section: Discussionsupporting

confidence: 76%

Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

Asimuddin

Gutta

Ansari³

et al. 2017

COPD Res Pract

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“…Rangasamy et al (98) also reported an upregulation of a variety of antioxidant enzymes after mice were exposed to cigarette smoke. Interestingly, Harju et al (46) observed that the expression of superoxide dismutase (SOD) (an antioxidant enzyme) is higher in the central bronchial and alveolar epithelium of smokers with COPD than in that of nonsmokers, demonstrating the active involvement of antioxidants during oxidative stress.…”

Section: Role Of Reactive Oxygen Species In Copdmentioning

confidence: 99%

Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments

Zuo

Sergakis

et al. 2014

American Journal of Physiology-Lung Cellular and Molecular Phys

215

139

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Cigarette smoking (CS) can impact the immune system and induce pulmonary disorders such as chronic obstructive pulmonary disease (COPD), which is currently the fourth leading cause of chronic morbidity and mortality worldwide. Accordingly, the most significant risk factor associated with COPD is exposure to cigarette smoke. The purpose of the present study is to provide an updated overview of the literature regarding the effect of CS on the immune system and lungs, the mechanism of CS-induced COPD and oxidative stress, as well as the available and potential treatment options for CS-induced COPD. An extensive literature search was conducted on the PubMed/Medline databases to review current COPD treatment research, available in the English language, dating from 1976 to 2014. Studies have investigated the mechanism by which CS elicits detrimental effects on the immune system and pulmonary function through the use of human and animal subjects. A strong relationship among continued tobacco use, oxidative stress, and exacerbation of COPD symptoms is frequently observed in COPD subjects. In addition, therapeutic approaches emphasizing smoking cessation have been developed, incorporating counseling and nicotine replacement therapy. However, the inability to reverse COPD progression establishes the need for improved preventative and therapeutic strategies, such as a combination of intensive smoking cessation treatment and pharmaceutical therapy, focusing on immune homeostasis and redox balance. CS initiates a complex interplay between oxidative stress and the immune response in COPD. Therefore, multiple approaches such as smoking cessation, counseling, and pharmaceutical therapies targeting inflammation and oxidative stress are recommended for COPD treatment.

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“…Altered levels of expression and activity of SODs in either lung or red blood cells were observed both in patients with COPD and in animals exposed to CS (10,15,22,42), whereas transgenic mice expressing SOD were reported to be resistant to elastase-or CS-induced pulmonary emphysema (12,44). However, the low affinity of SOD for tissues and low stability in plasma, with a half-life of a few minutes, are obstacles for its clinical use.…”

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confidence: 99%

Superiority of PC-SOD to other anti-COPD drugs for elastase-induced emphysema and alteration in lung mechanics and respiratory function in mice

Tanaka

Sato

Aoshiba

et al. 2012

American Journal of Physiology-Lung Cellular and Molecular Phys

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Bronchodilators (such as ipratropium bromide), steroids (such as fluticasone propionate), and newly developed anti-inflammatory drugs (such as roflumilast) are used for patients with chronic obstructive pulmonary disease (COPD). We recently reported that lecithinized superoxide dismutase (PC-SOD) confers a protective effect in mouse models of COPD. We here examined the therapeutic effect of the combined administration of PC-SOD with ipratropium bromide on pulmonary emphysema and compared the effect of PC-SOD to other types of drugs. The severity of emphysema in mice was assessed by various criteria. Lung mechanics (elastance) and respiratory function (ratio of forced expiratory volume in the first 0.05 s to forced vital capacity) were assessed. Administration of PC-SOD by inhalation suppressed elastase-induced pulmonary emphysema, alteration of lung mechanics, and respiratory dysfunction. The concomitant intratracheal administration of ipratropium bromide did not alter the ameliorating effects of PC-SOD. Administration of ipratropium bromide, fluticasone propionate, or roflumilast alone did not suppress the elastase-induced increase in the pulmonary level of superoxide anion, pulmonary inflammatory response, pulmonary emphysema, alteration of lung mechanics, or respiratory dysfunction as effectively as did PC-SOD. PC-SOD, but not the other drugs, showed a therapeutic effect even when the drug was administered after the development of emphysema. PC-SOD also suppressed the cigarette smoke-induced pulmonary inflammatory response and increase in airway resistance. Based on these results, we consider that the inhalation of PC-SOD would be therapeutically beneficial for COPD.

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Manganese superoxide dismutase is increased in the airways of smokers' lungs

Cited by 44 publications

References 31 publications

Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments

Superiority of PC-SOD to other anti-COPD drugs for elastase-induced emphysema and alteration in lung mechanics and respiratory function in mice

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