Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population

Tu, Hua; Pan, Kai; Zhang, Yang; Li, Wen Qing; Ling, Jun; Li, Ji You; You, Wei

doi:10.1158/1055-9965.epi-09-1174

Cited by 16 publications

(12 citation statements)

References 42 publications

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“…On the basis of our cross‐sectional study at baseline, we found that the total score of H. pylori antibodies was markedly increased in subjects with CAG and IM, particularly for CAG, supporting our previous findings that H. pylori may play an important role in the inflammation process and early stage of gastric lesions . Interestingly, no significant association with DYS was found, consistent with the hypothesis and our previous studies that with the progression of gastric lesions toward GC, H. pylori can be lost in the stomach mucosa owing to the changed internal environment, associated with declining antibody positivity (86.8% for CAG versus 78.0% for DYS or 83.5% for CAG versus 75.2% for DYS) and titers. Indeed, when comparing baseline serum IgG titer by ELISA between CAG and DYS groups of cohort 1, we found that the mean IgG titer was lower in the DYS group than in the CAG group (2.79 ± 1.64 for CAG versus 2.43 ± 1.80 for DYS, p = 0.0128).…”

Section: Discussionsupporting

confidence: 90%

Helicobacter pylori antibody responses and evolution of precancerous gastric lesions in a Chinese population

Pan

Formichella

Zhang

et al. 2013

Intl Journal of Cancer

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Helicobacter pylori-specific proteins are involved in gastric carcinogenesis. To investigate the seroprevalence of six H. pylorispecific antibodies in patients with different gastric histology, and the impact of seropositivities on the evolution of precancerous gastric lesions, a follow-up study was conducted in Linqu County, China. The seropositivities for CagA, VacA, GroEL, UreA, HcpC and gGT were assessed by recomLine analysis in 573 H. pylori-positive subjects and correlated with evolution of precancerous gastric lesions. We found that the score of H. pylori recomLine test was significantly increased in subjects with chronic atrophic gastritis (CAG, p < 0.0001) or intestinal metaplasia (IM, p 5 0.0125), and CagA was an independent predictor of advanced gastric lesions, adjusted odds ratios (ORs) were 2.54 (95% CI 5 1.42-4.55) for IM and 2.38 (95% CI 5 1.05-5.37) for dysplasia (DYS). Moreover, seropositivities for CagA and GroEL were identified as independent predictors for progression of gastric lesions in a longitudinal study, and ORs were 2.89 (95% CI 5 1.27-6.59) and 2.20 (95% CI 5 1.33-3.64), respectively. Furthermore, the risk of progression was more pronounced in subjects with more than three positive antigens (p for trend 5 0.0003). This population-based study revealed that seropositivities for CagA and GroEL might be potential markers to identify patients infected with high-risk H. pylori strains, which are related to the development of GC in a Chinese high-risk population, and recomLine test might serve as a tool for risk stratification.Helicobacter pylori (H. pylori) is a Gram-negative bacterium identified as the strongest known risk factor for gastric cancer (GC). 1 H. pylori infection can induce chronic gastritis, persisting for decades and eventually progressing to chronic atrophic gastritis (CAG), intestinal metaplasia (IM), dysplasia (DYS) and GC. 2,3 Our two randomized, placebo-controlled factorial-design intervention trials in Linqu County, a highrisk area of GC in Shandong Province, China, indicated that H. pylori eradication significantly reduces the risk of precancerous gastric lesions and subsequent GC, [4][5][6] suggesting that H. pylori eradication could be an effective strategy to prevent GC.However, although about half of the world's population is infected with H. pylori, only a minority of infected subjects

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Section: Discussionsupporting

confidence: 90%

Helicobacter pylori antibody responses and evolution of precancerous gastric lesions in a Chinese population

Pan

Formichella

Zhang

et al. 2013

Intl Journal of Cancer

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“…Catalase has been reported to be responsible for the detoxification of H 2 O 2 , which is an effective inhibitor of SOD. Other researchers reported the same results [ 32 , 33 ].…”

Section: Discussionsupporting

confidence: 77%

Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats

Refaie

Amin

El‐Tahawy

et al. 2016

Journal of Toxicology

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Nephrotoxicity is one of the limiting factors for using doxorubicin (DOX). Interleukin 1 has major role in DOX-induced nephrotoxicity, so we investigated the effect of interleukin 1 receptor antagonist diacerein (DIA) on DOX-induced nephrotoxicity. DIA (25 and 50 mg/kg/day) was administered orally to rats for 15 days, in the presence or absence of nephrotoxicity induced by a single intraperitoneal injection of DOX (15 mg/kg) at the 11th day. We measured levels of serum urea, creatinine, renal reduced glutathione (GSH), malondialdehyde (MDA), total nitrites (NOx), catalase, and superoxide dismutase (SOD). In addition, caspase-3, tumor necrosis factor alpha (TNFα), nuclear factor kappa B (NFκB) expressions, and renal histopathology were assessed. Our results showed that DOX-induced nephrotoxicity was ameliorated or reduced by both doses of DIA, but diacerein high dose (DHD) showed more improvement than diacerein low dose (DLD). This protective effect was manifested by significant improvement in all measured parameters compared to DOX treated group by using DHD. DLD showed significant improvement of creatinine, MDA, NOx, GSH, histopathology, and immunohistochemical parameters compared to DOX treated group.

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“…The frequency distributions of C and T alleles were found to be respec- has the similar CC genotype frequency as seen in AfricanAmerican [35], Finn [36], and Italian populations [37]. We detected considerably lower CC genotype frequency than those found in Korean [38], Japan [39], Chinese [40] and Taiwan [41] populations and higher frequencies than those found in American [23], Polish [42], Danish [43], German [44] and Russian [45] populations. Eventually, CC genotype frequency in populations of the eastern countries, were lower (between 0-17%) found than the western countries (between 42-67%) ( Table 4).…”

Section: Resultssupporting

confidence: 75%

Manganese-Superoxide Dismutase (MnSOD) Polymorphisms

Siliğ

Taş²,

Pınarbaşı³

2015

Turk J Bioch

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Objective: Manganese superoxide dismutase (MnSOD,SOD2), the only known superoxide scavenger in mitochondria, may be particularly important for antioxidant defense because mitochondria are the major sites for cellular metabolism and hence production of reactive oxygen species. Methods: In this study, 440 Turkish individuals were genotyped for polymorphisms of SOD2 gene. The distribution of these polymorphisms in this population was examined using a PCR-RFLP method. Results: In the present study, a total of 440(females: 201, 46% and males: 239, 54%) healthy individuals were studied. The mean age of the study population was 54,41±5,76 years (males, 55,34±5,76; females, 53,12±7,16 and males: 239, 54%) unrelated healthy volunteers from central Anatolia. There was no age and sex restriction for selection of the healthy volunteers, who were free of any chronic diseases, living in the same geographic area, and having no history of any cancer. We attempted to include all the control studies published to data on the SOD2 rs4880 polymorphism. DNA isolationTwo milliliters peripheral blood samples were collected in to citrate containing tubes from all subjects. DNA was extracted from whole blood by salting out procedure as soon as the samples reached to laboratory [19]. GenotypingThe distribution of these polymorphisms was examined using a PCR-RFLP method. For amplifying the SOD2 rs4880 polymorphism, forward primer 5'-ACC AGC AGG CAG CTG GCG CCG G-3' and reverse primer 5'-GCG TTG ATG TGA GGT TCC AC-3'were used. PCR reactions contained 0,75 µL (25 pmol/µL) of each primer, 2µL dNTPs (1mmol/L), 1,5µL of 25 mmol/L MgCI2, 1.5 Units of Taq DNA polymerase and 16,2µL sterile deionized water. DNA 50-100 ng is in a total volume of 50 µL. The Statistical analysisAll statistical analyses were performed using the Statistical Package for Social Sciences Program (SPSS, version 11). The Chi-square (X 2 ) test was used to evaluate the association between healthy individuals and SOD genotypes. Genotype, allele frequencies was estimated by counting. Hardy-Weinberg equilibrium between expected and observed genotype distributions was assessed using the X

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Manganese Superoxide Dismutase Polymorphism and Risk of Gastric Lesions, and Its Effects on Chemoprevention in a Chinese Population

Abstract: Background: Manganese superoxide dismutase is the primary antioxidant enzyme in the mitochondria and is involved in carcinogenesis. To investigate the association between MnSOD Val 16 Ala polymorphism

Cited by 16 publications

References 42 publications

Helicobacter pylori antibody responses and evolution of precancerous gastric lesions in a Chinese population

Helicobacter pylori antibody responses and evolution of precancerous gastric lesions in a Chinese population

Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats

Manganese-Superoxide Dismutase (MnSOD) Polymorphisms

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