Mango leaf extract synthesized silver nanorods exert anticancer activity on breast cancer and colorectal carcinoma cells

Vadakkepushpakath, Anoop Narayanan; Jacob, Rani; Paulson, Jinu Maria; Dineshkumar, B.; Narayana, Charyulu R.

doi:10.1016/j.jddst.2017.11.023

Cited by 27 publications

(13 citation statements)

References 21 publications

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“…Using aqueous mango leaves extract, we found that the antioxidantrich plants may have a pivotal role in the reduction of silver to form minute yellow-brown AgNPs. The characteristics of our biogenic AgNPs were confirmed by measuring XRD, SEM, and TEM as previously described 15,20,34,35 .…”

Section: Discussionmentioning

confidence: 99%

“…The dried leaves were powdered and 15 g of the powdered leaves was mixed with 150 mL of 50% ethanol for 24 h in a dark place with occasional agitation at room temperature. The ethanolic extract was stored at room temperature until use 15 .…”

Section: Preparation Of Mango Leaves Extractmentioning

confidence: 99%

“…Then, the mixture was centrifuged at 10,000 rpm for 10 min. The collected pellets were washed several times with Milli-Q water and the precipitates were dried at room temperature 15 .…”

Section: Synthesis Of Silver Nanoparticlesmentioning

confidence: 99%

“…Mangiferin can act as a reducing agent in the production of silver nanoparticles. Additionally, it may also act as a stabilizing and capping agent for the synthesized AgNPs, leading to the enhancement of the anti-tumor activity 15 . The present study aimed to prepare stable and ecofriendly AgNPs using biological methods and to evaluate the potency of AgNPs against Ehrlich ascites carcinoma (EAC) in a murine model.…”

Section: Introductionmentioning

confidence: 99%

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Biogenic silver nanoparticles induce apoptosis in Ehrlich ascites carcinoma

et al. 2020

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Introduction: Plant-mediated synthesis of silver nanoparticles (AgNPs) is accounted as an ecofriendly process. The present study was conducted to estimate the potency of biogenic AgNPs against Ehrlich ascites carcinoma (EAC) cells in vitro and EAC-bearing mice in vivo. Methods: AgNPs were prepared using mango leaves extract and characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), and transmission electron microscopy (TEM). Ehrlich ascites carcinoma (EAC) mouse model was established by intraperitoneal injection of 1 x 106 EAC cells. Biogenic AgNPs- alone or combined with Doxorubicin (DOX)- was administered intraperitoneally day by day for two weeks. Results: Biologically synthesized AgNPs showed a cytotoxic effect against cultured EAC cells but with less toxicity toward normal cells compared to DOX, which had strong cytotoxicity against both cells. Biogenic AgNPs alone or combined with DOX triggered the cytotoxicity against the EAC-bearing mouse model via decreasing body weight, tumor volume, and the number of viable tumor cells. The combined treatment (AgNPs-DOX) ameliorated the drastic effect induced by injection of EAC cells through improving liver and kidney functions compared to those treated with DOX alone. In addition, the combined treatment showed an elevation in the expression of Bax and caspase-3, and a reduction in the expression of Bcl-2 protein in the EAC cells. Furthermore, this combined treatment effectively arrested the cell cycle at the G0/G1 phase. Moreover, the combined treatment with AgNPs-DOX caused a significant reduction in the activity of ornithine decarboxylase (ODC). Conclusion: These findings suggest that biogenic AgNPs could be useful in developing a potent combination therapy against different types of cancers.

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Section: Discussionmentioning

confidence: 99%

Section: Preparation Of Mango Leaves Extractmentioning

confidence: 99%

“…Then, the mixture was centrifuged at 10,000 rpm for 10 min. The collected pellets were washed several times with Milli-Q water and the precipitates were dried at room temperature 15 .…”

Section: Synthesis Of Silver Nanoparticlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biogenic silver nanoparticles induce apoptosis in Ehrlich ascites carcinoma

et al. 2020

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“…В последнее время разработка простых, экономичных и экологически чистых методов синтеза наноматериалов является одной из важнейших областей исследования в нанотехнологии. В связи с этим все бóльшую популярность приобретает синтез наночастиц с помощью природных материалов, растительных компонентов или микроорганизмов [19][20][21][22].…”

Section: наноструктуры нанотрубкиunclassified

Синтез Наночастиц Серебра При Помощи Ультразвука И Галлуазита Для Создания Нанокомпозита С Антибактериальными Свойствами

Чередниченко¹,

Евтюгин²,

Нигаматзянова³

et al. 2020

Rossijskie nanotehnologii

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Создание антимикробных нанокомпозитов является актуальным направлением в борьбе с микробным обсеменением и биопленкообразованием у микроорганизмов. Существующие методы получения нанокомпозитов на основе наночастиц серебра достаточно трудоемки, затратны и неэкологичны, в связи с чем возникла необходимость разработки нового метода их синтеза, удовлетворяющего указанным выше требованиям. Впервые проведен синтез наночастиц серебра и получен новый нанокомпозит с использованием нанотрубок галлуазита и ультразвука. Просвечивающая электронная микроскопия показала наличие наночастиц серебра на поверхности и внутри нанотрубок галлуазита, а картирование образца – равномерное распределение наночастиц серебра в нанокомпозите. Установлено, что полученный нанокомпозит обладает антибактериальной активностью в отношении бактерий Serratia marcescens более чем в 2 раза относительно контроля. Метод движения по типу роения показал, что диаметр миграции у штамма S. marcescens составил 2.05 ± 0.05 см, а с нанокомпозитом – 1.63 ± 0.04 см, что свидетельствует о способности ингибировать формирование биопленок у данных бактерий. Полученный нанокомпозит в дальнейшем может быть применен в качестве добавки к различным материалам или в качестве покрытия для борьбы с бактериальным обсеменением различных поверхностей и материалов.

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Biological Activities of Nanoparticles and Mechanism of Action

Chaudhary

Masram

2020

Model Organisms to Study Biological Activities and Toxicity of Nanoparticles

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Mango leaf extract synthesized silver nanorods exert anticancer activity on breast cancer and colorectal carcinoma cells

Cited by 27 publications

References 21 publications

Biogenic silver nanoparticles induce apoptosis in Ehrlich ascites carcinoma

Biogenic silver nanoparticles induce apoptosis in Ehrlich ascites carcinoma

Синтез Наночастиц Серебра При Помощи Ультразвука И Галлуазита Для Создания Нанокомпозита С Антибактериальными Свойствами

Biological Activities of Nanoparticles and Mechanism of Action

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