Mangosteen Peel Extract Increases Transforming Growth Factor-Beta in the Wound Healing Process

Abstract

Natural ingredients, such as mangosteen, are necessary to help wound healing. Mangosteen possesses antibacterial and anti-inflammatory properties to help accelerate the time of the inflammatory phase so that the proliferative phase can occur immediately. 8 This anti-inflammatory agent interacts with the factor-kB activator receptor, which can promote the formation of osteoclasts and bone resorption. 9 This beta-factor (TGF-β) can stimulate matrix protein synthesis, which plays a role in bone remodeling, cell differentiation, embryonic development, immune function, and hormone secretion. 10 Due to the vital role TGF-β plays in wound healing, a study was conducted to determine the expression of TGF-β in the wound healing process after Wistar rats were given oral mangosteen peel extract following tooth extraction.