Manipulation of Human Ovarian Function: Physiological Concepts and Clinical Consequences

Fauser, B. C. J. M.

doi:10.1210/er.18.1.71

Cited by 189 publications

(94 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…High FSH levels occurring during the luteo-follicular transition give rise to continued growth of a limited number (cohort) of follicles (23). Subsequent development of this cohort during the follicular phase is dependent on continued stimulation by gonadotropins.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of Ovarian Function in an Adult Woman with McCune-Albright Syndrome

Laven¹,

Lumbroso²,

Sultan³

et al. 2001

Journal of Clinical Endocrinology & Metabolism

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Dynamics of Ovarian Function in an Adult Woman with McCune-Albright Syndrome

Laven¹,

Lumbroso²,

Sultan³

et al. 2001

Journal of Clinical Endocrinology & Metabolism

View full text Add to dashboard Cite

“…LH establishes follicle selection, plays an important role in final stages of follicular maturation (resumption of oocyte meiosis), follicular rupture and oocyte expulsion with support of corpus luteum formation. Correct LH level stimulate androstendion production in theca cells to be followed by its aromatization to estradiol in the granulosa cells under the influence of FSH [17,18]. Patients with PCOS may have elevated amplitude and frequency of LH pulses which can manifest with increased total LH serum concentration (60% of women) [19,20].…”

Section: Introductionmentioning

confidence: 99%

Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study

Kurzawa

Ciepiela

Bączkowski

et al. 2008

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose Embryological and clinical efficacy of gonadotropinreleasing hormone (GnRH) antagonist and agonist stimulation protocols in non-obese women with polycystic ovarian syndrome (PCOS) were compared. Methods A prospective randomized study. Setting: Medical University Hospital. Patients: 70 infertile PCOS patients; 33 in GnRH antagonist and 37 in GnRH agonist group. Results Similar mature metaphase II oocyte rate (76% vs. 76%) was observed in both protocols. Optimal pronuclear morphology zygotes dominated in both groups (64% vs. 66%). Transferred embryo quality did not differ in both protocols. No significant differences between both protocols were found in delivery rate ( p=0.481), pregnancy rate ( p=0.810), multiple pregnancy rate ( p=0.501), miscarriage rate ( p=0.154), fertilization rate ( p=0.388) and implantation rate (p=1.000). Duration of stimulation and total follicle-stimulating hormone (FSH) dose were significantly lower in GnRH antagonist protocol ( p=0.0005). Conclusions GnRH antagonist and agonist protocols in non-obese PCOS patients yield similar embryological and clinical outcomes. Shorter duration of treatment and lower FSH requirement in GnRH antagonist group may be financially beneficial and therefore attractive for patients.

show abstract

“…Follicle-stimulating hormone (FSH) plays a major role during folliculogenesis, and its action is mediated by FSH receptor (FSHR) (Fauser and van Heusden 1997). Urinary and recombinant FSH are major gonadotropins that have been widely used for controlled ovarian hyperstimulation (COH) in assisted reproductive technology (ART).…”

Section: Introductionmentioning

confidence: 99%

“…Regarding the ligand, many researchers have attempted to evaluate differences in the distribution of FSH isoforms, to identify the presence of inhibitors or antibodies that are combined with FSH, and to characterize the different signals caused by the various FSH isoforms (Fauser and van Heusden 1997;Ulloa-Aguirre et al 1995;Fauser 1996). However, few reports have demonstrated the efficacy of measuring FSH isoforms for predicting the prognosis of ART cycles.…”

Section: Introductionmentioning

confidence: 99%

Follicle-stimulating hormone receptor gene polymorphism and ovarian responses to controlled ovarian hyperstimulation for IVF-ET

et al. 2006

View full text Add to dashboard Cite

This study was performed to investigate the association between FSH receptor (FSHR) gene polymorphism at position 680 and the outcomes of controlled ovarian hyperstimulation (COH) for in vitro fertilization and embryo transfer (IVF-ET) in Korean women. Two hundred and sixty-three patients under 40 years of age who underwent IVF-ET procedures were included in this study. Patients with polycystic ovary syndrome, endometriosis, or a previous history of ovarian surgery were excluded. Following extraction of genomic DNA, the FSHR polymorphism at position 680 was determined by polymerase chain reaction and restriction fragment length polymorphism analysis. The FSHR genotype distribution was 41.8% for Asn/ Asn, 45.6% for Asn/Ser, and 12.5% for Ser/Ser FSHR genotype groups. Although there was no difference among the three genotype groups in terms of the age and infertility diagnosis of study subjects, the basal levels of FSH (day 3) were significantly different [5.7 ± 0.3 IU/l (mean±SEM), 6.0 ± 0.3 IU/l, and 8.2 ± 0.9 IU/l for Asn/Asn, Asn/Ser, and Ser/Ser groups, respectively. The Ser/Ser group tended to require a higher dose of gonadotropins for COH, and tended to show lower serum estradiol levels at the time of hCG administration than the other two groups, though these differences did not reach statistical significance. The numbers of oocytes retrieved tended to be different for the three groups (9.6 ± 0.6, 10.2 ± 0.6, and 7.9 ± 0.8 for Asn/Asn, Asn/Ser, and Ser/Ser groups, respectively). Clinical pregnancy rate was significantly higher in Asn/Asn, compared to the others (45.7 vs. 30.5%, P=0.013). The homozygous Ser/Ser genotype of FSHR polymorphism at position 680 may be associated with a reduced ovarian response to COH for IVF-ET, while Asn/Asn genotypes showed a higher pregnancy rate.

show abstract

Manipulation of Human Ovarian Function: Physiological Concepts and Clinical Consequences

Cited by 189 publications

References 75 publications

Dynamics of Ovarian Function in an Adult Woman with McCune-Albright Syndrome

Dynamics of Ovarian Function in an Adult Woman with McCune-Albright Syndrome

Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study

Follicle-stimulating hormone receptor gene polymorphism and ovarian responses to controlled ovarian hyperstimulation for IVF-ET

Contact Info

Product

Resources

About