The press loading and unloading manipulator is a kind of intelligent equipment based on automation, which is specially developed for realizing the automation and unmanned production of the press shop. It can replace the worker’s work by implementing the manual editing program and greatly improve the efficiency of production and quality. The design optimized the traditional transmission scheme comparison and molded the structure based on the solid works modeling. The key supporting parts of the manipulator are analyzed by the finite element method. The simulation results showed that the manipulator can satisfy the designed loading requirements and guarantee the designed accuracy.