Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations

Świerzko, Anna St.; Cedzyński, Maciej; Domżalska-Popadiuk, Iwona; MacDonald, Shirley L.; Borkowska-Klos, Monika; Atkinson, Anne; Szala, Agnieszka; Jopek, Aleksandra; Jensenius, Jens C.; Kawakami, Michiyuki; Szczapa, Jerzy; Matsushita, Misao; Szemraj, Janusz; Turner, Marc; Kilpatrick, David C.

doi:10.1016/j.molimm.2009.02.022

Cited by 31 publications

(28 citation statements)

References 28 publications

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“…Like MBL and the ficolins, MASP-2 expression was significantly lower in preterm and premature neonates and also demonstrated a gestational increase in expression, the magnitude of which was much greater in the study by Sallenbach et al (2011). No association was found between MASP-2 concentration and susceptibility to infection in this population (Swierzko et al 2009b). …”

Section: Masp-2mentioning

confidence: 71%

“…Although MASPs-1 and -3 can modify complement activation, MASP-2 appears to be the critical molecule catalysing lectin pathway responses in vivo (Schwaeble et al 2011). Only two studies to date have assessed MASP-2 concentrations in neonatal populations (Sallenbach et al 2011;Swierzko et al 2009b). Like MBL and the ficolins, MASP-2 expression was significantly lower in preterm and premature neonates and also demonstrated a gestational increase in expression, the magnitude of which was much greater in the study by Sallenbach et al (2011).…”

Section: Masp-2mentioning

confidence: 97%

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Off to a slow start: Under-development of the complement system in term newborns is more substantial following premature birth

2012

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Section: Masp-2mentioning

confidence: 71%

Section: Masp-2mentioning

confidence: 97%

Off to a slow start: Under-development of the complement system in term newborns is more substantial following premature birth

2012

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“…van der Zwet et al have found no relationship between MBL genotype and the risk of nosocomial infection in preterm neonates in an NICU [22]. Swiersko et al have found no association between mannose-binding-lectin-associated serine protease-2 gene polymorphism and prematurity, low birthweight, or perinatal infections [18]. Bodamer et al have demonstrated that fetal MBL2 genotype might be an additional genetic factor contributing to the risk of premature delivery [12].…”

Section: Discussionmentioning

confidence: 99%

Mannose-binding lectin codon 54 gene polymorphism in relation to risk of nosocomial invasive fungal infection in preterm neonates in the neonatal intensive care unit

Aydemir

Önay

Oğuz

et al. 2010

The Journal of Maternal-Fetal & Neonatal Medicine

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“…However, the upregulation of this molecule appears to be more significant based on the Mascot-SELDI-matrix matching scores. Levels of MASP2 were reported to be elevated in neonatal infections (26), and mouse models lacking this molecule showed protection of myocardial and gastrointestinal ischemia/reperfusion injury (27). The possible role of this molecule in dynapenia remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Urinary diagnostic proteomic markers for dynapenia in cancer patients

et al. 2018

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Abstract. Dynapenia is defined as the age-related loss of muscle strength, and plays a significant role in the loss of physical function and increased risk of disability among older individuals. The need for an early diagnosis supports the search for a biomarker that reflects muscle 'weakening'. This has previously proven difficult due to patient heterogeneity at presentation and lack of understanding of the underlying molecular mechanisms. The aim of the present study was to identify potential urinary biomarkers of dynapenia in patients undergoing potentially curative surgery for upper gastrointestinal cancer. Maximum isometric knee extensor strength (strain gauge) and maximum leg extensor power (Nottingham power rig) measurements were taken. Cut-off values for dynapenia were based on the Allied Dunbar national fitness survey. Values below the 5th percentile for the population matched for age and sex on the Allied Dunbar national fitness survey were used to stratify the cohort into dynapenic or normal. Urine samples taken at induction of anaesthesia were analysed by SELDI-TOF mass spectrometry using CM10 and IMAC30 chip-types to establish statistically significant m/z peak fingerprint patterns, followed by in-gel LC-MS/MS to identify molecular constituents. Statistical analysis of decision-tree calculations using Biomarker Pattern software resulted in models with sensitivities of 86 and 96%, specificities of 81 and 89%, and overall correctness of 84 and 93%, when applied to the entire cohort for power and strength measurement-based stratifications using the IMAC30 chip-type and the CM10 chip-type, respectively. The molecular identities of 10 peaks of interest were further investigated. After subtraction of potentially unrelated proteins, they were identified as fragments of Annexin A1, collagen α-1 (XV), perlecan and myotrophin. These results demonstrate that urinary screening can be used to define cancer-associated muscle weakness, and the identification of potential biomarkers could be invaluable in establishing a rapid test to measure and assess dynapenia in the clinical setting.

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Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations

Cited by 31 publications

References 28 publications

Off to a slow start: Under-development of the complement system in term newborns is more substantial following premature birth

Off to a slow start: Under-development of the complement system in term newborns is more substantial following premature birth

Mannose-binding lectin codon 54 gene polymorphism in relation to risk of nosocomial invasive fungal infection in preterm neonates in the neonatal intensive care unit

Urinary diagnostic proteomic markers for dynapenia in cancer patients

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