Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction

Shushimita, Shushimita; Pol, Pieter van der; Bruin, Ron W. F. de; IJzermans, Jan N.M.; Kooten, Cees van; Dor, Frank J. M. F.

doi:10.1371/journal.pone.0137795

Cited by 14 publications

(12 citation statements)

References 44 publications

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“…In this study, we have chosen the 8-week DR protocol for old animals. Since in young rats 4 weeks of DR had a very pronounced nephroprotective effect [ 30 ] which was consistent with other studies [ 15 , 51 ], we did not change the details of this protocol besides its length. The majority of papers dealing with a short-term DR in old rodents used 8 weeks of DR and it resulted in a range of beneficial consequences.…”

Section: Discussionsupporting

confidence: 77%

Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats

Andrianova

Zorova

Pevzner

et al. 2020

Aging

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Dietary restriction (DR) is the strategy ameliorating the morbidity of various pathologies, including age-associated diseases. Acute kidney injury (AKI) remains a problem for the elderly with DR being a promising approach for diminishing its consequences. We evaluated the possible nephroprotective potential of short-term DR in young and old rats. DR in young rats resulted in pronounced beneficial effects normalizing lipid metabolism (triglycerides concentration, adiponectin level) activating autophagic-lysosomal system evaluated by LC3II/LC3I ratio, LAMP1, p62/SQSTM1 levels, and LysoTracker Green staining. DR had a remarkable recovering effect on mitochondrial structure and functions including regaining of mitochondrial membrane potential, the elevation of SIRT-3, PGC-1α, Bcl-XL levels and partial restoration of ultrastructure. The beneficial effects of DR resulted in the mitigation of oxidative stress including a decrease in levels of protein carbonylation and lipid peroxidation. Aging led to decreased activity of autophagy, elevated oxidative stress and impaired kidney regenerative capacity. Eventually, in old rats, even 8-week DR was not able to ameliorate AKI, but it caused some rejuvenating effects including elevation of mitochondrial membrane potential and Bcl-X L levels, as well as lowered severity of the oxidative stress. Thus, the age-associated decline of protective signaling demands extended DR to achieve nephroprotective potential in old animals.

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Section: Discussionsupporting

confidence: 77%

Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats

Andrianova

Zorova

Pevzner

et al. 2020

Aging

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“…Moreover, lifestyle factors can also impact MBL. Fasting and dietary restrictions reduce circulating levels of MBL as well as mRNA expression in liver [ 39 ], However, after adjustment MBL for these confounders levels remained associated with cardiovascular events, indicating a direct and independent effect of MBL on cardiovascular risk. This study revealed that MBL levels are the same in HD patients and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients

et al. 2016

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BackgroundHemodialysis patients have higher rates of cardiovascular morbidity and mortality compared to the general population. Mannose-binding lectin (MBL) plays an important role in the development of cardiovascular disease. In addition, hemodialysis alters MBL concentration and functional activity. The present study determines the predictive value of MBL levels for future cardiac events (C-event), cardiovascular events (CV-event) and all-cause mortality in HD patients.MethodsWe conducted a prospective study of 107 patients on maintenance hemodialysis. Plasma MBL, properdin, C3d and sC5b-9 was measured before and after one dialysis session. The association with future C-events, CV-events, and all-cause mortality was evaluated using Cox regression models.ResultsDuring median follow-up of 27 months, 36 participants developed 21 C-events and 36 CV-events, whereas 37 patients died. The incidence of C-events and CV-events was significantly higher in patients with low MBL levels (<319 ng/mL, lower quartile). In fully adjusted models, low MBL level was independently associated with increased CV-events (hazard ratio 3.98; 95 % CI 1.88–8.24; P < 0.001) and C-events (hazard ratio 3.96; 95 % CI 1.49–10.54; P = 0.006). No association was found between low MBL levels and all-cause mortality. Furthermore, MBL substantially improved risk prediction for CV-events beyond currently used clinical markers.ConclusionsLow MBL levels are associated with a higher risk for future C-events and CV-events. Therefore, MBL levels may help to identify hemodialysis patients who are at risk to develop cardiovascular disease.Electronic supplementary materialThe online version of this article (doi:10.1186/s12967-016-0995-5) contains supplementary material, which is available to authorized users.

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“…In mammals, MBL-A and MBL-C are serum proteins that are mainly synthesised by the liver and small intestine (Ezekowitz et al 1988 ; Sastry et al 1991 ; Hansen et al 2000 ) (Table 1 ). In mice, mRNA expression of MBL genes was also detected in various other tissues (Shushimita et al 2015 ), and this may also be these case for Bovidae, particularly the rumen and udder. The normal serum concentrations of bovine MBL-A and MBL-B have not been clearly defined but are estimated to be 0.8–7.4 μg/mL (Wang et al 2012 ).…”

Section: Tissue Distribution Physiological Role and Protection Agaimentioning

confidence: 87%

Bovine Collectins: Role in Health and Disease

Tsolaki

Kishore

2021

The Collectin Protein Family and Its Multiple Biological Activities

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Mammalian collectins play key roles in innate immunity, health and disease. These have been well studied in humans and other mammalian species, but much has still to be learned about the bovine collectins and the role they may play in the health and disease in cattle which have significant economic implications to the agricultural and food industries. This chapter focuses on the bovine collectins, which are important innate immune molecules and play a key role in immunoregulation and protection against pathogens. Like other mammalian collectins, they all have a related structure comprised of an N-terminal triple-helical collagen-like region and a ligand binding C-terminal C-type lectin domain. The bovine collectins are able to recognise and bind to complex glycoconjugates, particularly on the surface of microbes, neutralising infection, enhancing clearance by phagocytes and modulating immune response. Here, we will review the bovine collectins, surfactant proteins A (SP-A) and D (SP-D), mannose binding lectins (MBL-A and MBL-C), conglutinin (CGN), collectin 43 (CL-43) and collectin 46 (CL-46), and their role in bovine immunity and disease. We will particularly focus on the structural, functional and anti-microbial roles of these collectins with an additional focus on genetic polymorphisms in their genes and predisposition to infectious diseases in the bovine host. In the absence of specific data on the bovine host, findings from studies with other mammalian collectins will be discussed with respect to bovine health and disease.

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Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction

Cited by 14 publications

References 44 publications

Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats

Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats

Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients

Bovine Collectins: Role in Health and Disease

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