Mannitol an Adjuvant in Local Anaesthetic Solution: Recent Concept &amp; Changing Trends (Review)

Kumar, Anand; Khanna, Ruchika; Srivastava, Ram; Azhar, Iqbal; Wadhwani, Puneet

doi:10.7860/jcdr/2014/9629.5187

Cited by 1 publication

(1 citation statement)

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“…Mannitol is a pleasant, refreshing, and biocompatible sugar with high water solubility constant and is widely used in pharmaceutical formulations as a sweetener, diluent, and isotonizer 21 . Furthermore, mannitol has enhanced the buccal anesthetic effect of LDC solutions in inferior alveolar nerve block by heightening the drug permeability 22 . These features make it possible to consider mannitol a very versatile component to aid the delivery of local anesthetics in the buccal cavity.…”

Section: Discussionmentioning

confidence: 99%

Quality by Design-driven investigation of the mechanical properties of mucoadhesive films for needleless anesthetics administration

Ferreira

Thomaz

Duarte

et al. 2021

Rev. Ciênc. Farm. Básica Apl.

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Objectives: To systematically evaluate the effects of hydroxypropyl methyl cellulose (HPMC) type (E5LV, E15LV, and K100LV); plasticizer type (glycerol and mannitol), plasticizer loading (0.12 and 0.24% w/w); and loading of prilocaine and lidocaine hydrochlorides combined at 1:1 ratio (0 and 47 mg/cm 2 ) in the mechanical properties of buccal films. Methods: A quality by design (QbD) approach based on a full factorial design (3 x 2 3 ) and complementarily multivariate statistical tools i.e., principal component analysis (PCA), response surface methodology (RSM), and correlation matrix were used in this pursuit. The thickness, elongation at break, tensile strength, force at break, and Young`s modulus of the anesthetic buccal films obtained by solvent casting were assessed. Results: The QbD, PCA and RSM altogether demonstrated that all studied formulation variables, mainly the drug loading, affect the mechanical properties of the films at different significance levels. The multivariate analysis yielded the modelling of elongation at break, tensile strength, and force at break, which significantly correlated with each other. The drugs exerted a synergic plasticizing effect on the films, and the use of HPMC K100 LV (with greater hydroxypropyl substitution degree and viscosity) and mannitol favored their elasticity and resistance. Furthermore, the majority of the films fulfilled the requirements for buccal administration due to their softness and mechanical resistance. Conclusion: Mannitol is suitable plasticizer for manufacturing HPMC anesthetic buccal films with improved mechanical properties. These results are a step forward in the rational development of formulations for the replacement of needles in dentistry.

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Section: Discussionmentioning

confidence: 99%