Mannitol therapy revisited (1940–1997)

Better, Ori S.; Rubinstein, I.; Winaver, Joseph; Knöchel, James P.

doi:10.1038/ki.1997.409

Cited by 164 publications

(107 citation statements)

References 52 publications

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“…However, these benefits are not supported currently by evidence from randomized trials. 97 Augmentation of urine output with loop diuretics may be beneficial in patients with relative oliguria and fluid overload. While controversial, myoglobin clearance can be augmented by hemofiltration with high-flux hemofilters (molecular weight cut-off 30-60 kDa).…”

Section: Rhabdomyolysis and Myoglobinuric Akimentioning

confidence: 99%

Review article: Acute kidney injury in critical illness

Bagshaw

Bellomo

Devarajan

et al. 2010

Can J Anesth/J Can Anesth

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Purpose This review provides a focused and comprehensive update on emerging evidence related to acute kidney injury (AKI).Principal findings Acute kidney injury is a significant clinical problem that increasingly complicates the course of hospitalization and portends worse clinical outcome for sick hospitalized patients. The recent introduction of consensus criteria for the diagnosis of AKI (i.e., RIFLE/AKIN classification) have greatly improved our capacity not only to standardize the diagnosis and classification of severity of AKI, but also to facilitate conducting comparative epidemiologic studies in an effort to better understand the burden of adult and pediatric AKI and its syndromes (i.e., septic, cardio-renal, hepato-renal). The characterization of several novel AKI-specific biomarkers (i.e., neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, and interleukin-18) is extending our understanding of the pathophysiology of AKI. Moreover, these biomarkers appear to have clinical relevance for early detection and they provide prognostic value. These innovations are aiding in the design of epidemiologic surveys and randomized trials of therapeutic interventions. Strategies for prevention Editor's Note: This article is the first of two linked special review articles published in this issue of the Journal. The concept of these articles emerged from the scientific content of the 2010 Acute Kidney Injury (AKI) and Renal Support in Critical Illness Symposium, hosted in Edmonton, Alberta. This review (Part 1) provides a focused and comprehensive update on emerging evidence in the diagnosis and classification of AKI, on specific AKI syndromes, and on the prevention and conservative management of hospitalized patients with AKI. Abstracts presented at this meeting were selected on the basis of peer review by the Scientific Committee and were accepted for presentation at the AKI 2010 Symposium, and appear as Electronic Supplementary Material at

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Section: Rhabdomyolysis and Myoglobinuric Akimentioning

confidence: 99%

Review article: Acute kidney injury in critical illness

Bagshaw

Bellomo

Devarajan

et al. 2010

Can J Anesth/J Can Anesth

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“…4,5,9,10 It is rapidly excreted in the urine with a half-life of 70-100 minutes. 4,8 Pathogenesis of MI-ARF/MION has …”

Section: Discussionmentioning

confidence: 99%

“…4,8,9 As a diuretic, mannitol induces diuresis because it is not reabsorbed in the renal tubule, thereby increasing the osmolality of the glomerular filtrate, facilitating excretion of water, and inhibiting the renal tubular reabsorption of sodium, chloride, and other solutes. 4,5,9,10 It is rapidly excreted in the urine with a half-life of 70-100 minutes. 4,8 Pathogenesis of MI-ARF/MION has …”

Section: Discussionmentioning

confidence: 99%

“…7,8 The authenticity of this hypothesis in context of MI-ARF/MION however remains uncertain because of scarce data and the renal dynamics need yet to be clarified. 4,[6][7][8][9][10] We herein report the first case of MI-ARF/ MION in a patient with stroke and otherwise healthy kidneys from Pakistan followed by a comprehensive review of literature concerning the pathogenesis, clinical presentation, risk factors, diagnostic approach, management and prognosis of ON in general and MI-ARF/MION in particular.…”

Section: Introductionmentioning

confidence: 99%

“…Smith noted the osmotic diuretic effect of mannitol followed by Selkurt in 1945 that showed effects of mannitol on ARF (acute renal failure). [2][3][4] Several cases implicating MI-ARF (mannitol-induced ARF)/ MION (mannitol-induced ON) have been recognized. Excessive administration of mannitol is potentially dangerous in producing mannitol intoxication syndrome and ARF, especially in the elderly or patients with pre-existing renal failure.…”

Section: Introductionmentioning

confidence: 99%

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Osmotic nephrosis with mannitol: review article

et al. 2014

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Mannitol is commonly used to lower intracranial and intraocular pressures. Large doses/massive infusions of mannitol have been found to be associated with acute renal failure (MI-ARF), that is, osmotic nephrosis. While many researchers have reported individual experiences with this pathology, we felt that there is need of an updated comprehensive review of all reported cases with elaboration of etiology, pathogenesis, diagnosis and management plan for MI-ARF. The purpose of the present communication is to share our own experience with MI-ARF, to review the effect of mannitol on kidney function and to highlight the dynamics of MI-ARF with considerations for the cautious use of mannitol in patients with risk factors for kidney diseases. KeywordsAcute renal failure/injury, mannitol, osmotic nephrosis, mannitol-induced acute renal failure, mannitol-induced osmotic nephrosis History

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