Mannose-binding lectin and innate immunity in bronchiectasis

Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis Progression

“…MBL, as a primarily liver-derived soluble opsonin, holding a critical position in innate immunity mainly through initiating lectin pathway activation, also can serve multiple modulatory functions apart from complement activation in tissue homeostasis and various diseases. 10 , 16 , 17 , 34 In addition, MBL has been described as an acute-phase protein that increases and plays vital roles in the acute-phase response. 35 , 36 Local inflammation or injuries in the liver during hepatic fibrosis could induce the acute-phase protein expression to maintain homeostasis and tissue repair.…”

“…In addition, MBL could exert different biologic functions apart from complement activation, playing crucial roles in tissue homeostasis and various diseases. 10 , 16 , 17 Emerging evidence has indicated that MBL is involved in the development of fibrosis in CLD patients, including patients with liver cirrhosis, 18 hepatitis C virus patients with more severe fibrosis, 19 individuals with schistosomiasis-induced liver fibrosis, 20 and patients with HBV-related liver cirrhosis. 21 Our previous study showed that MBL, as an essential component of the liver microenvironment, suppresses tumor development via interaction with local stromal cells.…”

A QCM study of strong carbohydrate–carbohydrate interactions of glycopolymers carrying mannosides on substrates

“…Mannose is of high importance, and in particular, much attention has been given to the specific interaction of mannose with C-type lectins. 16,17 It would be surprising if CCIs existed between simple mannose moieties.…”