Mannose-binding lectin gene polymorphism and its effect on short term outcomes in preterm infants

Doğan, Peli̇n; Özkan, Hilal; Köksal, Nilgün; Oral, Haluk Barbaros; Bagci, Onur; Varal, İpek Güney

doi:10.1016/j.jped.2019.03.001

Cited by 7 publications

(4 citation statements)

References 24 publications

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“…Elevated C3a was also proposed to differentiate RDS from RDS accompanied by perinatal asphyxia (34). Knowledge concerning the role of lectin pathway factors in RDS is limited to a single report by Dogan et al (35), showing significantly higher frequency of MBL2 genotypes associated with low concentration of MBL in affected neonates. Our results showing increased probability of development of RDS in preterms with low ficolin-2 confirm an association of the complement system with this complication.…”

Section: Discussionmentioning

confidence: 99%

Association of low ficolin-2 concentration in cord serum with respiratory distress syndrome in preterm newborns

Gajek

Swierzko²,

Jarych³

et al. 2023

Front. Immunol.

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IntroductionFicolin-2 is a serum pattern recognition molecule, involved in complement activation via the lectin pathway. This study aimed to investigate the association of ficolin-2 concentration in cord blood serum with complications related to premature birth.Methods546 premature neonates were included. The concentration of ficolin-2 in cord blood serum was determined by a sandwich TRIFMA method. FCN2 genetic variants were analysed with RFLP-PCR, allele-specific PCR, Sanger sequencing or allelic discrimination using TaqMan probes method.FindingsCord blood serum ficolin-2 concentration correlated positively with Apgar score and inversely with the length of hospitalisation and stay at Neonatal Intensive Care Unit (NICU). Multivariate logistic regression analysis indicated that low ficolin-2 increased the possibility of respiratory distress syndrome (RDS) diagnosis [OR=2.05, 95% CI (1.24-3.37), p=0.005]. Median ficolin-2 concentration was significantly lower in neonates with RDS than in premature babies without this complication, irrespective of FCN2 gene polymorphisms localised to promoter and 3’untranslated regions: for patients born <33 GA: 1471 ng/ml vs. 2115 ng/ml (p=0.0003), and for patients born ≥33 GA 1610 ng/ml vs. 2081 ng/ml (p=0.012). Ficolin-2 level was also significantly lower in neonates requiring intubation in the delivery room (1461 ng/ml vs. 1938 ng/ml, p=0.023) and inversely correlated weakly with the duration of respiratory support (R=-0.154, p<0.001). Interestingly, in the neonates born at GA <33, ficolin-2 concentration permitted differentiation of those with/without RDS [AUC=0.712, 95% CI (0.612-0.817), p<0.001] and effective separation of babies with mild RDS from those with moderate/severe form of the disease [AUC=0.807, 95% CI (0.644-0.97), p=0.0002].ConclusionLow cord serum ficolin-2 concentration (especially in neonates born at GA <33 weeks) is associated with a higher risk of developing moderate/severe RDS, requiring respiratory support and intensive care.

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Section: Discussionmentioning

confidence: 99%

Association of low ficolin-2 concentration in cord serum with respiratory distress syndrome in preterm newborns

Gajek

Swierzko²,

Jarych³

et al. 2023

Front. Immunol.

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“…The MBL exon 1 polymorphisms may play a role in the predisposition to SLE, progression of RA, development of leprosy and tuberculosis (31)(32)(33)(34) . Preterm infants with MBL2 gene polymorphisms are at an increased risk of developing respiratory distress syndrome and sepsis (35) . The MBL genotypes AA for rs180040 (G/A), GG for rs1800451 (G/A), and CC for rs5030737 (T/C) have a higher prevalence in patients infected with Coronavirus Disease 2019 (COVID-19).…”

Section: Discussionmentioning

confidence: 99%

What is the Role of Mannose-Binding Lectin Gene Polymorphism in the Development of Acute Post-Streptococcal Glomerulonephritis?

Güven¹,

Bak²,

Serdaroğlu³

et al. 2021

BUCH

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Objective: This study aims to determine the effects of the mannose-binding lectin (MBL) gene polymorphism on the clinical and laboratory findings, response to treatment, and progress of patients with acute post-streptococcal glomerulonephritis (APSGN). Methods: Codon 54 polymorphism found in exon 1 of the MBL gene was investigated by polymerase chain reaction-restriction fragment length polymorphism method in 110 children followed up with the diagnosis of APSGN and compared with healthy control group. Results: The normal allele AA and, the variant alleles AB and BB gene frequencies were determined within the APSGN group as 74.5%, 20% and, 5.5%, respectively. No statistically significant difference was found with concerning to the gene polymorphism in the APSGN group when compared with the control group (p>0.05). No correlation was found in the patient group between gene polymorphism and the presence of hematuria, edema, central nervous system findings, and blood pressure (p>0.05). Concerning laboratory findings during the diagnosis, no correlation existed between the gene polymorphism and high levels of urea, creatine, total cholesterol, and triglycerides, low levels of albumin, and the presence of proteinuria (p>0.05). Within the first years following the diagnosis, no statistically significant difference was found in the glomerular filtration rates, blood creatine levels, proteinuria levels, duration of microscopic hematuria and proteinuria between the patients with the gene polymorphism and those without the gene polymorphism (p>0.05) Conclusion: Our study determined that the MBL gene polymorphism was not important in the development, the laboratory and clinical findings, or the progression of the patients with APSGN.

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“…MBL insufficiency or dysfunction is caused by three structural variants in exon 1. One hypothesis states that these MBL2 gene variants result in susceptibility to various infectious and autoimmune diseases, such as rheumatoid arthritis [ 2 ], Kawasaki disease [ 3 , 4 ], recurrent vulvovaginal candidiasis [ 5 ], respiratory distress syndrome in preterm infants [ 6 ], hepatitis B infection [ 7 ], severe acute respiratory syndrome coronavirus infection [ 8 ], etc. However, whether these MBL2 gene variants are really associated with susceptibility to various diseases remains unknown and controversial.…”

Section: Introductionmentioning

confidence: 99%

Association of the Mannose-Binding Lectin 2 BB Genotype with COVID-19-Related Mortality

Kashiwagi

Suzuki

Takahashi

et al. 2023

Life

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Mannose-binding lectin (MBL) is crucial in first-line immune defenses. There are still many unknown factors regarding the mechanisms causing variability in the clinical course of coronavirus disease 2019 (COVID-19). In Japan, there have been few reports to date regarding the association between MBL and COVID-19. It has been demonstrated that the MBL2 gene B variant at codon 54 (rs1800450) is associated with variabilities in the clinical course of COVID-19. We aimed to investigate how the level of serum MBL and the codon 54 variant of MBL (rs1800450) affect the disease severity of COVID-19. A total of 59 patients from the fourth wave and 49 patients from the fifth wave in Japan were analyzed based on serum MBL levels using ELISA and the genotype of MBL2 codon 54 using PCR reaction. There was no significant association between serum MBL levels and age. MBL2 genotype was independent of age, there was no significant difference in different COVID-19 severities, MBL genotypes, and serum MBL levels. Binary logistic regression analysis to identify predisposing factors for severe COVID-19 symptoms demonstrated that patients with the BB genotype had a higher risk of death from COVID-19. Our results quantitatively demonstrated that the BB genotype might be a factor associated with death from COVID-19.

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Mannose-binding lectin gene polymorphism and its effect on short term outcomes in preterm infants

Cited by 7 publications

References 24 publications

Association of low ficolin-2 concentration in cord serum with respiratory distress syndrome in preterm newborns

Association of low ficolin-2 concentration in cord serum with respiratory distress syndrome in preterm newborns

What is the Role of Mannose-Binding Lectin Gene Polymorphism in the Development of Acute Post-Streptococcal Glomerulonephritis?

Association of the Mannose-Binding Lectin 2 BB Genotype with COVID-19-Related Mortality

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