Mannose-binding lectin level and deficiency is not associated with inflammatory bowel diseases, disease phenotype, serology profile, and NOD2/CARD15 genotype in a large Hungarian cohort

Papp, Mária; Lakatos, Péter L.; Hársfalvi, Jolán; Farkas, Gyula; Palatka, Károly; Udvardy, M.; Molnár, Tamás; Farkas, Klaudia; Nagy, Ferenc; Veres, Gábor; Lakatos, László; Kovács, Ágota; Dinya, Tamás; Kocsis, Ágnes Katalin; Papp, J.; Altorjay, István

doi:10.1016/j.humimm.2010.01.012

Cited by 13 publications

(2 citation statements)

References 51 publications

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“…MBL concentrations were measured by sandwich enzyme-linked immunosorbent assay as described and used previously at our institution [25]. In short, murine monoclonal antibody (Statens Serum Institut, Denmark), which preferentially detects functional MBL oligomers, was used.…”

Section: Mbl Levelsmentioning

confidence: 99%

Membrane array and multiplex bead analysis of tear cytokines in systemic sclerosis

et al. 2015

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Although serious ocular manifestations of systemic sclerosis (SSc) have been described, tear analysis of patients with SSc has not been performed in previous studies. Our aim was to measure a wide panel of cytokines and chemokines in tears of patients with SSc and to assess the most significant molecules with a more sensitive and specific method. Unstimulated tear samples were collected from nine patients with SSc and 12 age- and gender-matched healthy controls. The relative levels of 102 different cytokines were determined by a cytokine array, and then absolute levels of four key cytokines were determined by a magnetic bead assay. Array results revealed shifted cytokine profile characterized by predominance of inflammatory mediators. Of the 102 analyzed molecules, nine were significantly increased in tears of patients with SSc. Based on the multiplex bead results, C-reactive protein, interferon-γ-inducible protein-10, and monocyte chemoattractant protein-1 levels were significantly higher in tears of patients with SSc. Our current data depict a group of inflammatory mediators, which play a significant role in ocular pathology of SSc; furthermore, they might function as excellent candidates for future therapeutic targets in SSc patients with ocular manifestations.

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Section: Mbl Levelsmentioning

confidence: 99%

Membrane array and multiplex bead analysis of tear cytokines in systemic sclerosis

et al. 2015

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“…[42][43][44][45] Serological markers were also identified and their association to the disease severity combined with the genotype data of NOD2/CARD15 and TLR4 were investigated. [46][47][48][49] PPARc plays a role in regulation of gut inflammation; it inhibits the epithelial inflammatory response, is required for the maintenance of innate antimicrobial immunity in the colon, and is a new promising target in IBD therapy. 20,24 Polymorphisms of PPARc have been examined in diabetes and obesity, and also in disorders with autoimmune origins such as psoriasis, psoriatic arthritis, asthma, and IBD.…”

Section: Discussionmentioning

confidence: 99%

Association of peroxisome proliferator-activated receptor gamma polymorphisms with inflammatory bowel disease in a Hungarian cohort

Póliska

Penyige

Lakatos

et al. 2012

Inflammatory Bowel Diseases

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Mannose-binding lectin deficiency is not associated with Anti-Saccharomyces cerevisiae antibody in Korean Crohn's disease patients

Kim

et al. 2014

Clinica Chimica Acta

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Mannose-binding lectin level and deficiency is not associated with inflammatory bowel diseases, disease phenotype, serology profile, and NOD2/CARD15 genotype in a large Hungarian cohort

Cited by 13 publications

References 51 publications

Membrane array and multiplex bead analysis of tear cytokines in systemic sclerosis

Membrane array and multiplex bead analysis of tear cytokines in systemic sclerosis

Association of peroxisome proliferator-activated receptor gamma polymorphisms with inflammatory bowel disease in a Hungarian cohort

Mannose-binding lectin deficiency is not associated with Anti-Saccharomyces cerevisiae antibody in Korean Crohn's disease patients

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