Mannose‐binding lectin levels in children with asthma

Uğuz, Ayşen; Berber, Zafer; Çoşkun, Mesut; Akbas, S. Halide; Yegin, Olcay

doi:10.1111/j.1399-3038.2005.00258.x

Cited by 35 publications

(43 citation statements)

References 32 publications

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Section: Discussionmentioning

confidence: 99%

“…Earlier studies have reported increased plasma MBL levels and activity in allergic patients [18,19]. High MBL levels in allergic patients also associate with their increased blood eosinophils, which are systemic components of airway inflammation in asthma, and these high levels are sustained even in remission [18,19]. In view of these observations and that of the present study it may be proposed that, in response to an environmental insult, MBL levels may rise in all the individuals, but in those individuals who have elevated plasma MBL levels due inherently to the presence of gene polymorphisms, MBL levels may rise even further and contribute to the increased severity of allergic diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Varied levels of MBL in the serum have been associated with protection and/or susceptibility to several infectious and non-infectious diseases [13]. Earlier studies have reported elevated plasma MBL levels and complement activity in allergic patients [18,19]. These high plasma MBL levels could be a result of the disease process and/or they may be determined genetically.…”

Section: Introductionmentioning

confidence: 99%

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Elevated levels of mannan-binding leptin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL

Kaur

Gupta

Shah

et al. 2006

Clinical and Experimental Immunology

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SummaryMannan-binding lectin (MBL), an important component of innate immunity, binds to a range of foreign antigens and initiates the lectin complement pathway. Earlier studies have reported high plasma MBL levels in allergic patients in comparison to healthy controls. In view of varied plasma MBL levels being determined by genetic polymorphisms in its collagen region, we investigated the association of single nucleotide polymorphisms (SNPs) in the collagen region of human MBL with respiratory allergic diseases. The study groups comprised patients of bronchial asthma with allergic rhinitis ( n = = = = 49) and allergic bronchopulmonary aspergillosis (APBA) ( n = = = = 11) and unrelated agematched healthy controls of Indian origin ( n = = = = 84). A novel intronic SNP, G1011A of MBL , showed a significant association with both the patient groups in comparison to the controls ( P < < < < 0·01). Patients homozygous for the 1011A allele showed significantly higher plasma MBL levels and activity than those homozygous for the 1011G allele ( P < < < < 0·05). The 1011A allele also showed a significant correlation with high peripheral blood eosinophilia ( P < < < < 0·05) and low forced expiratory volume in 1 s (FEV 1 ) ( P < < < < 0·05) of the patients. We conclude that the 1011A allele of MBL may contribute to elevated plasma MBL levels and activity and to increased severity of the disease markers in patients of bronchial asthma with allergic rhinitis and ABPA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Elevated levels of mannan-binding leptin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL

Kaur

Gupta

Shah

et al. 2006

Clinical and Experimental Immunology

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“…Recently, several studies have mentioned the important role of MBL on pathophysiological mechanisms of allergies [9][10][11]. Some researchers have defined that MBL concentration of serum was significantly different in allergic patients and healthy people [11][12][13]. In our study of atopic subjects, the mean age was 32.5 and the mean serum level of MBL was 3088.3 ± 669.8 ng/ml.…”

Section: Discussionmentioning

confidence: 62%

Untitled

2017

Cent Asian J Med Sci

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Objectives: Mannose-binding lectin (MBL) is a vital protein of an innate immune system synthesized by the liver. The serum level of MBL is associated with an increased susceptibility to infection with a high risk of allergic and autoimmune diseases. The aim of this study was to determine the profile of serum levels of MBL in atopic and healthy Mongolian subjects. Methods: Serum samples were collected from 219 healthy Mongolian adult blood donors and 216 atopic subjects. We analyzed the MBL level in each serum by using the double-antibody sandwich ELISA method. Results: The mean serum level of MBL was 3088.28 ± 669.8 ng/ ml in atopic subjects and 2165.07 ± 708.5 ng/ml in healthy groups. In males, the MBL mean serum level of atopic subjects was 3012.8 ± 783.16 ng/ml and 2073.33 ± 678.26 ng/ml in the healthy group of males. The MBL mean serum level of female atopic subjects was 3138.22 ± 580.6 ng/ml and 2263.61 ± 733.1 ng/ml in the healthy group of females. Low association and significant differences were observed between MBL levels of atopic and healthy subjects. Conclusion: The serum level of MBL in atopic subjects was comparatively higher than in subjects of the healthy group. Significant differences were observed between mean levels of MBL between the different age groups.

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“…On the other hand, elevated serum MBL levels might play a role in inflammatory process through the activation of complement [26]. There are some reports demonstrating elevated plasma MBL levels and complement activity in allergic patients although it has not been clarified whether these results are related with genotypic features or disease pathology [27,28]. However, some studies have suggested that genetically reduced MBL levels increase the susceptibility for COPD and asthma [4,29,30], while some others demonstrated the risk of COPD and asthma in MBL deficient patients were not increased [31,32].…”

Section: Discussionmentioning

confidence: 99%

Mannose binding lectin (MBL) gene polymorphism and relationship between serum MBL concentrations in COPD patients

Ulutas¹,

Taneli²,

Alpaydın³

et al. 2012

Turk J Bioch

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Aim: We aimed to assess mannose-binding lectin (MBL) gene polymorphisms and serum MBL concentrations in a sample of Turkish chronic obstructive pulmonary disease (COPD) patients as well as in cigarette smokers. Furthermore, we looked for the possible correlations of serum MBL concentrations with pulmonary function tests. Materials and methods: Forty COPD patients and 40 healthy volunteers were included. The subjects were thereafter divided into 2 groups according to smoking status. Circulating MBL concentrations were assessed by ELISA and MBL gene polymorphisms were assessed by real time PCR method. Spirometry was performed to all subjects except healthy nonsmokers. Results: In the whole study population MBL gene frequencies were found 82.5%(66/80) for A/B genotype, 15%(12/80) for D/D genotype and 2.5%(2/80) for B/B genotype. Circulating MBL concentrations were found 2103±1311 ng/ml and 2324±1001 ng/ml in smoker and nonsmoker COPD patients, respectively, whereas they were 1746±1142 ng/ml in smoker and 2040±879 ng/ml in nonsmoker controls. No statistical difference was found between the study groups for serum MBL concentrations. Serum MBL concentration correlated positively with cigarette smoking (r=0.280, p=0.030) and negatively with pulmonary functions (FEV 1 (r=-0.246, p=0.058). Conclusion: To our knowledge, no previous study has been performed in healthy Turkish population to detect the MBL gene polymorphisms. A/B genotype was the most frequent MBL variant in our study population; however serum MBL concentrations were not found compatible with MBL deficiency. We believe these results need further investigation which includes larger series to evaluate whether serum MBL concentration is a risk factor for COPD. Key Words: COPD, cigarette smoking, MBL, MBL variant, early markers, innate immunity Conflict of interest: Authors declare no conflict of interest ÖZET Amaç: Bu çalışmada bir grup Türk Kronik Obstruktif Akciğer Hastalığı (KOAH) hastası ve sigara içen örneklemde mannoz bağlayan lektin (MBL) gen polimorfizmi ve serum MBL konsantrasyonun saptanması amaçlanmıştır. Aynı zamanda, MBL konsantrasyonunun solunum fonksiyon testleri ile olası ilişkisi de incelenmiştir. Gereç ve Yöntem: 40 KOAH hastası 40 sağlıklı gönüllü çalışmaya dahil edildi. Hastalar ve gönüllüler sigara içme durumlarına göre 2 gruba bölündü. Dolaşımsal MBL konsantrasyonu ELISA metoduyla, MBL gen polimorfizmi de gerçek zamanlı PCR metoduyla çalışıldı.. Spirometre sağlıklı sigara içmayenler dışında tüm çalışma grubuna uygulandı. Bulgular: Tüm çalışma grubunda MBL gen frekansı A/B genetipi için %82.5 (66/80), D/D genotipi için %15 (12/80) ve B/B genotipi için %2.5 (2/80) bulundu. Dolaşımsal MBL konsantrasyonu sigara içen KOAH hastalarında 2103±1311 ng/ml, içmeyenlerde 2324±1001 ng/ml saptanırken, sigara içen gönüllülerde 1746±1142 ng/ml, içmeyenlerde 2040±879 ng/ml bulundu. Serum MBL konsantrasyonlarında gruplar arasında farklılık yoktu. Serum MBL konsantrasyonu sigara içimi ile pozitif (r=0.280, p=0.030), solunum fonksiyon testleri ile neg...

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Mannose‐binding lectin levels in children with asthma

Cited by 35 publications

References 32 publications

Elevated levels of mannan-binding leptin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL

Elevated levels of mannan-binding leptin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL

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Mannose binding lectin (MBL) gene polymorphism and relationship between serum MBL concentrations in COPD patients

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