Mannose-Functionalized Isoniazid-Loaded Nanostructured Lipid Carriers for Pulmonary Delivery: In Vitro Prospects and In Vivo Therapeutic Efficacy Assessment

Ahalwat, Shaveta; Bhatt, Dinesh Chandra; Rohilla, Surbhi; Jogpal, Vikas; Sharma, Kirti; Virmani, Tarun; Kumar, Girish; Alqahtani, Ali S.; Noman, Omar M.; Almoiliqy, Marwan

doi:10.3390/ph16081108

Cited by 13 publications

(4 citation statements)

References 49 publications

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“…In this study, 5 mg of completely dried metal NPs and 2 mL of plant aqueous extract were mixed with KBr, dried, and compressed to form KBr pellets and further spectra were obtained. Dynamic light scattering (DLS) and Zeta potential by Zetasizer nano series -Nano ZS 90 (Malvern Panalytical) was used to study the size distribution of the synthesized NPs in the colloidal solution [33]. The prepared NPs were dispersed in Milli-Q water with ultrasonification so that no extra peak appeared.…”

Section: Characterizationmentioning

confidence: 99%

Amomum subulatum Fruit Extract Mediated Green Synthesis of Silver and Copper Oxide Nanoparticles: Synthesis, Characterization, Antibacterial and Anticancer Activities

Dhir,

Dutt,

Singh

et al. 2023

Processes

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This research presents a straightforward, effective, and eco-friendly method for the production of silver nanoparticles (AgNPs) and copper oxide nanoparticles (CuONPs) using the dried fruit of Amomum subulatum as a reducing, stabilizing, and capping agent. The formation of AgNPs and CuONPs is supported by the presence of a surface plasmon resonance band (SPR) at 440 nm for AgNPs and 245 nm for CuONPs. Additionally, the identification of specific biomolecules responsible for the synthesis of AgNPs and CuONPs was confirmed through FTIR spectra analysis. The Transmission electron microscope (TEM) images demonstrated that AgNPs and CuONPs had spherical shapes, with mean particle diameters of 20.6 nm and 24.7 nm, respectively. X-ray diffraction and selected area electron diffraction (SAED) analyses provided evidence of the crystalline nature of the synthesized AgNPs and CuONPs. Additionally, the presence of silver and copper elements was observed through energy-dispersive X-ray spectroscopy (EDS) analysis. Furthermore, the antibacterial activity of AgNPs was found to be superior to that of CuONPs against human pathogens such as Escherichia coli, Staphylococcus aureus, and Bacillus subtilis. The cytotoxic activity of the biosynthesized nanoparticles (NPs) was evaluated in vitro against human cervical cells (HeLa) and human breast cells (MCF-7). In MCF-7 cells, the IC50 value for AgNPs was estimated to be 39.79 µg/mL, while that of CuONPs was 83.89 µg/mL. In HeLa cells, the IC50 value for AgNPs was 45.5 µg/mL, and for CuONPs, it was 97.07 µg/mL. For the first time, an eco-friendly method for the synthesis of AgNPs and CuONPs from fruit extract of Amomum subulatum has been discussed along with their comparative evaluation study. These results highlight the promising applications of the eco-friendly synthesized AgNPs and CuONPs as effective agents against microbial infections and potential candidates for cancer therapy.

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Section: Characterizationmentioning

confidence: 99%

Amomum subulatum Fruit Extract Mediated Green Synthesis of Silver and Copper Oxide Nanoparticles: Synthesis, Characterization, Antibacterial and Anticancer Activities

Dhir,

Dutt,

Singh

et al. 2023

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“…The model that created a linear plot and had the highest (r 2 ) value was the best fit for the drug release data [28].…”

Section: Kinetic Studymentioning

confidence: 99%

Enhancement of Curcumin’s Anti-Psoriatic Efficacy via Formulation into Tea Tree Oil-Based Emulgel

Reena,

Mittal,

Faizan

et al. 2023

Gels

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Psoriasis is a chronic inflammatory skin disease characterized by the hyperproliferation and aberrant differentiation of epidermal keratinocytes. It is a debilitating condition that can cause significant physical and emotional distress. Natural anti-psoriatic agents have been investigated as alternatives to conventional allopathic medications, as they have notable limitations and drawbacks. Curcumin and tea tree oil are cost-efficient and effective anti-inflammatory medicines with less adverse effects compared to synthetic psoriasis medications. Our research endeavors to harness the therapeutic potential of these natural compounds by developing an herbal anti-psoriatic topical drug delivery system. This novel method uses curcumin and tea tree oil to create a bi-phasic emulgel drug delivery system. Formulations F1 (gel) and F2 (emulgel) have high drug content percentages of 84.2% and 96.7%, respectively. The emulgel showed better spreadability for cutaneous applications, with a viscosity of 92,200 ± 943 cp compared to the gel’s 56,200 ± 1725 cp. The emulgel released 94.48% of the drugs, compared to 87.58% for the gel. These formulations conform to the zero-order and Higuchi models, and their stability over a three-month period is crucial. In vivo, the emulgel healed psoriasis symptoms faster than the usual gel. The gathered results confirmed the emulgel’s potential as a drug delivery method, emphasizing the complementary benefits of tea tree oil and curcumin as an effective new therapy for psoriasis.

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“…Based on these results, targeting the mannose receptor for TB treatment appears promising, and intracellular co-localization of the bacteria and the nanocarrier is more likely given that they may use the same macrophage entry channel [135]. Numerous studies have concentrated on macrophage targeting via the mannose receptor and shown enhanced absorption of the mannosylated nanocarriers compared to non-targeted formulations [157,158].…”

Section: Mannose Targetingmentioning

confidence: 99%

Nanocarriers in Tuberculosis Treatment: Challenges and Delivery Strategies

Kumar,

Virmani,

Kumar

et al. 2023

Pharmaceuticals

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The World Health Organization identifies tuberculosis (TB), caused by Mycobacterium tuberculosis, as a leading infectious killer. Although conventional treatments for TB exist, they come with challenges such as a heavy pill regimen, prolonged treatment duration, and a strict schedule, leading to multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. The rise of MDR strains endangers future TB control. Despite these concerns, the hunt for an efficient treatment continues. One breakthrough has been the use of nanotechnology in medicines, presenting a novel approach for TB treatment. Nanocarriers, such as lipid nanoparticles, nanosuspensions, liposomes, and polymeric micelles, facilitate targeted delivery of anti-TB drugs. The benefits of nanocarriers include reduced drug doses, fewer side effects, improved drug solubility, better bioavailability, and improved patient compliance, speeding up recovery. Additionally, nanocarriers can be made even more targeted by linking them with ligands such as mannose or hyaluronic acid. This review explores these innovative TB treatments, including studies on nanocarriers containing anti-TB drugs and related patents.

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Mannose-Functionalized Isoniazid-Loaded Nanostructured Lipid Carriers for Pulmonary Delivery: In Vitro Prospects and In Vivo Therapeutic Efficacy Assessment

Cited by 13 publications

References 49 publications

Amomum subulatum Fruit Extract Mediated Green Synthesis of Silver and Copper Oxide Nanoparticles: Synthesis, Characterization, Antibacterial and Anticancer Activities

Amomum subulatum Fruit Extract Mediated Green Synthesis of Silver and Copper Oxide Nanoparticles: Synthesis, Characterization, Antibacterial and Anticancer Activities

Enhancement of Curcumin’s Anti-Psoriatic Efficacy via Formulation into Tea Tree Oil-Based Emulgel

Nanocarriers in Tuberculosis Treatment: Challenges and Delivery Strategies

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