Mantle Cell Lymphoma: the Role of Risk-Adapted Therapy and Treatment of Relapsed Disease

Tarockoff, Meri; González, Teresita Pérez; Ivanov, Stanislav; Sandoval-Sus, José

doi:10.1007/s11912-022-01297-x

Cited by 4 publications

(1 citation statement)

References 95 publications

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“…However, MCL patients develop drug resistance quickly, and refractory MCL patients have a median survival of only 1-2 years. In addition, a majority of MCL patients are in a late stage of the disease when diagnosed, and have a dismal long-term survival [5].…”

Section: Introductionmentioning

confidence: 99%

A Ferroptosis-Related Prognostic Model of Mantle Cell Lymphoma

Gao,

Wang,

Zhang

et al. 2023

Preprint

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Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin's lymphoma. Ferroptosis, an iron-dependent programmed cell death, is closely related to cancer prognosis. In this study, we established a model of ferroptosis-related genes for prognostic evaluation of patients with MCL. Using the single-cell RNA sequencing datasets GSE184031 and GSE32018 from the Gene Expression Omnibus, we identified 139 ferroptosis-related genes in MCL. Next, a prognostic model was constructed by Cox regression and LASSO regression analysis. In our model, the prognosis of MCL patients was assessed by risk scoring using 7 genes ANXA1, IL1B, YBX1, CCND1, MS4A1, MFHAS1 and RILPL2. The patients were divided into high-risk and low-risk groups based on our model, and the high-risk patients had inferior overall survival. Finally, according to our model and computational drug sensitivity analysis, four small molecule compounds, BMS-754807, SB216763, Doramapimod and Trametinib, were identified as potential therapeutic agents for patients with MCL. In summary, we provide a prognostic model with ferroptosis-related gene signature for MCL.

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Section: Introductionmentioning

confidence: 99%

A Ferroptosis-Related Prognostic Model of Mantle Cell Lymphoma

Gao,

Wang,

Zhang

et al. 2023

Preprint

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Research Progress in the Treatment of Non Hodgkin’s Lymphoma

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2024

JCPM

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Ferroptosis-related prognostic model of mantle cell lymphoma

Gao,

Wang,

Zhang

et al. 2024

Open Medicine

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Background Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin’s lymphoma. Ferroptosis, an iron-dependent programmed cell death, is closely related to cancer prognosis. In this study, we established a model of ferroptosis related genes for prognostic evaluation of patients with MCL. Methods Using the single-cell RNA sequencing datasets GSE184031 and mRNA sequencing data GSE32018 from the Gene Expression Omnibus, we identified 139 ferroptosis-related genes in MCL. Next a prognostic model was constructed by Cox regression and Least absolute selection and shrinkage Operator regression analysis. Finally, we used CIBERSORT to analyze the immune microenvironment and the “oncoPredict” package to predict potential drugs. Results In our model, the prognosis of MCL patients was assessed by risk scoring using 7 genes ANXA1, IL1B, YBX1, CCND1, MS4A1, MFHAS1, and RILPL2. The patients were divided into high-risk and low-risk groups based on our model, and the high-risk patients had inferior overall survival. Finally, according to our model and computational drug sensitivity analysis, four small molecule compounds, BMS-754807, SB216763, Doramapimod, and Trametinib, were identified as potential therapeutic agents for patients with MCL. Conclusion In summary, we provide a prognostic model with ferroptosis-related gene signature for MCL. This study provides a prognostic model with ferroptosis-related gene signature for MCL. The results show that the model helps predict prognosis in MCL.

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Mantle Cell Lymphoma: the Role of Risk-Adapted Therapy and Treatment of Relapsed Disease

Cited by 4 publications

References 95 publications

A Ferroptosis-Related Prognostic Model of Mantle Cell Lymphoma

A Ferroptosis-Related Prognostic Model of Mantle Cell Lymphoma

Research Progress in the Treatment of Non Hodgkin’s Lymphoma

Ferroptosis-related prognostic model of mantle cell lymphoma

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