2019
DOI: 10.3390/pharmaceutics11100492
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Manufacturing Different Types of Solid Dispersions of BCS Class IV Polyphenol (Daidzein) by Spray Drying: Formulation and Bioavailability

Abstract: Daidzein (DZ) is a polyphenolic compound belonging to Biopharmaceutical Classification System class IV, which shows that it may have limited therapeutic effects due to its low solubility and poor bioavailability. This study aimed to obtain high-purity DZ and prepare and characterize different types of solid dispersions (SDs) in order to enhance aqueous solubility and bioavailability. Excipients were investigated in order to manufacture different types of solid dispersions (SDs). Second-generation solid dispers… Show more

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Cited by 24 publications
(19 citation statements)
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“…The amorphous state of polyphenols is most often stabilized by hydrogen bonds. Recent work shows the amorphous solid dispersion of such polyphenols as quercetin [11,16,17], resveratrol [18], curcumin [18][19][20], naringenin [21], daidzein [22], and genistein [23]. The amorphous form of pterostilbene was obtained, for example, by Tzeng et al via nanoprecipitation with Eudragit ® e100 and polyvinyl alcohol (PVA) [24].…”
Section: Introductionmentioning
confidence: 99%
“…The amorphous state of polyphenols is most often stabilized by hydrogen bonds. Recent work shows the amorphous solid dispersion of such polyphenols as quercetin [11,16,17], resveratrol [18], curcumin [18][19][20], naringenin [21], daidzein [22], and genistein [23]. The amorphous form of pterostilbene was obtained, for example, by Tzeng et al via nanoprecipitation with Eudragit ® e100 and polyvinyl alcohol (PVA) [24].…”
Section: Introductionmentioning
confidence: 99%
“…Carriers and drugs are in a crystalline state in the first generation of SDs. In this case, high thermodynamic stability of the carrier results at lower dissolution rates compared with amorphous SDs (Panizzon et al, 2019). Second-generation SDs are prepared with amorphous polymers and the drug may be molecularly dissolved or dispersed.…”
Section: Pvp Solid Dispersions Containing Poloxamer 407 or Tpgs For T...mentioning
confidence: 99%
“…In fact, it is shown that low plasma and tissue levels associated with curcumin administration are due to its poor aqueous solubility, poor absorption, rapid metabolism, and rapid systemic elimination [ 177 ]. Daidzein is a PC commonly assigned to BCS Class IV [ 181 ]. Because of its low solubility and poor bioavailability, daidzein may have limited pharmaceutical value.…”
Section: Bcs Classification Of Polyphenolsmentioning
confidence: 99%