Manuka honey attenuates oxidative damage induced by H2O2 in human whole blood in vitro

Živković, Lada; Bajić, Vladan; Dekanski, Dragana; Čabarkapa-Pirković, Andrea; Giampieri, Francesca; Gasparrini, Massimiliano; Mazzoni, Luca; Potparević, Biljana Spremo

doi:10.1016/j.fct.2018.05.034

Cited by 10 publications

(5 citation statements)

References 37 publications

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“…This protective effect was in part attributed to the phenolic content of the honey samples [74]. The post-treatment of human whole blood samples from healthy volunteers with manuka honey resulted in significant protection of whole blood cells from oxidative damage induced by hydrogen peroxide monitored in vitro by comet assay [75]. To the extent of our knowledge, this is the first time that the protective effect of honey against UV genotoxicity has been demonstrated in human keratinocytes.…”

Section: Discussionmentioning

confidence: 79%

Honey Extracts Exhibit Cytoprotective Properties against UVB-Induced Photodamage in Human Experimental Skin Models

et al. 2020

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In the present study, we aimed to examine the antioxidant, antiaging and photoprotective properties of Greek honey samples of various botanical and geographical origin. Ethyl-acetate extracts were used and the and the total phenolic/flavonoid content and antioxidant capacity were evaluated. Honey extracts were then studied for their cytoprotective properties against UVB-induced photodamage using human immortalized keratinocytes (HaCaT) and/or reconstituted human skin tissue models. Specifically, the cytotoxicity, oxidative status, DNA damage and gene expression levels of specific matrix metalloproteinases (MMPs) were examined. Overall, the treatment of HaCaT cells with honey extracts resulted in lower levels of DNA strand breaks and attenuated the decrease in cell viability following UVB exposure. Additionally, honey extracts significantly decreased the total protein carbonyl content of the irradiated cells, however, they had no significant effect on their total antioxidant status. Finally, the extracts alleviated the UVB-induced up-regulation of MMPs-3, -7 and -9 in a model of reconstituted skin tissue. In conclusion, honey extracts exhibited significant photoprotective and antiaging properties under UVB exposure conditions and thus could be further exploited as promising agents for developing novel and naturally-based, antiaging cosmeceutical products.

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Section: Discussionmentioning

confidence: 79%

Honey Extracts Exhibit Cytoprotective Properties against UVB-Induced Photodamage in Human Experimental Skin Models

et al. 2020

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“…The referred activity of honey is attributed to its acidity (pH between 3.2 and 4.5), osmotic effect of its high sugar content [3], and also derived from H 2 O 2 generated which is involved in oxidative damage causing bacterial growth inhibition by DNA degradation [36]. Although H 2 O 2 is an important factor in the bacterial growth inhibition, polyphenolic compounds and their interaction with H 2 O 2 are the key factors responsible for honey high antibacterial activity [30].…”

Section: Resultsmentioning

confidence: 99%

Apitherapy of Septic Metacarpal and Metatarsal Wounds (An Experimental Study on Donkeys)

Hamouda¹,

Kuraa²,

El-Samieh³

et al. 2019

CMR

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Non-healed wounds are a significant problem in the healthcare system of the distal portions of the limbs. Nine types of honey were tested for wound healing judged by clinical gross healing parameters, rate of wound contraction and sings of epithelization histopathologically. Rounded full thickness skin wounds (1.5cm diameter) were performed at the distal portion of limbs. The wounds were infected by standard dose of MRSA (methicillin resistance Staph. aureus) for 72 hours. The tested types of honey were tested for MIC & MBC against clinical MRSA strain. Different types of honey were applied unprocessed as daily topical wound dressing for the infected wounds. Propolis with black seed honey followed by Hadramout sidr honey, then Egyptian sidr honey proved to have the most antimicrobial activity. Clinical healing appearance revealed that propolis with black seed honey, Egyptian sidr honey and Hadramout sidr honey showed the most preferable clinical parameters (gross appearance and rate of wound contraction), and histopathologically achieved the best healing epithelization 28 days after treatment. The study concluded that among different nine honey types retailed in Egyptian markets, all tested honey types had wound healing activities but with different potencies. Propolis with black seed, Egyptian sidr honey and Hadramout honey were the most potent with highly significance differences (P < 0.01), since achieving the most wound contraction rates, rapid epithelization post 28 days rather than the least MICs & MBCs values. While the marjoram and clover honey were the least effective.

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“…Živković et al. (2018) demonstrated that manuka honey is able to significantly reduce the oxidative effect of H 2 O 2 on DNA through in vitro assays. However, the authors comment that in vivo studies are needed to examine the antigenotoxic properties of manuka honey.…”

Section: Biological Activity Of Monofloral Honeysmentioning

confidence: 99%

Bioactive compounds in Apis mellifera monofloral honeys

Viteri

Zacconi

Montenegro

et al. 2021

Journal of Food Science

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Honey is a natural product with a sweet flavor. Honey is made by the honeybee (Apis mellifera L.) from the nectar of flowers or other plant secretions that are collected near the hive. These products are mixed with bee saliva and stored. Several studies have demonstrated that honey exhibits antioxidant, antimicrobial, nematicidal, antifungal, anticancer, and anti‐inflammatory activities. These properties are influenced by the plants from which the secretions are harvested, from the naturally occurring compounds present in the nectar. Studies of the properties and applications of honey have distinguished honey from other natural products due to the presence of certain compounds and due its bioactive properties. The focus of this review is to discuss the identified and isolated compounds from monofloral honey produced by A. mellifera, with specific emphasis on antioxidant and antimicrobial properties of honey and its therapeutic health benefits.

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Manuka honey attenuates oxidative damage induced by H2O2 in human whole blood in vitro

Cited by 10 publications

References 37 publications

Honey Extracts Exhibit Cytoprotective Properties against UVB-Induced Photodamage in Human Experimental Skin Models

Honey Extracts Exhibit Cytoprotective Properties against UVB-Induced Photodamage in Human Experimental Skin Models

Apitherapy of Septic Metacarpal and Metatarsal Wounds (An Experimental Study on Donkeys)

Bioactive compounds in Apis mellifera monofloral honeys

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