MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche

Wu, Ningbo; Sun, Haixiang; Xi, Zhao; Zhang, Yao; Tan, Jianmei; Qi, Yuanyuan; Wang, Qun; Ng, Melissa; Liu, Zhaoyuan; He, Lingjuan; Niu, Xiaoyin; Chen, Lei; Liu, Zhiduo; Li, Huabing; Zeng, Yi Arial; Roulis, Manolis; Liu, Dou; Cheng, Jinke; Zhou, Bin; Ng, Lai Guan; Zou, Duowu; Ye, Youqiong; Flavell, Richard A.; Ginhoux, Florent; Su, Bing

doi:10.1038/s41586-021-03283-y

Cited by 69 publications

(77 citation statements)

References 43 publications

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“…As a comparative analysis of the scRNA-seq data revealed substantial similarities among mesenchymal cell populations in the small intestine and colon (McCarthy et al 2020a ), it would be interesting to determine whether the MRISCs belong to or are significantly overlapped with the trophocyte population in colon. The Wu et al ( 2021 ) study reinforces the idea that remodeling of the mesenchymal cell niche can significantly influence the activity of intestinal stem cells and the development of intestinal diseases. In addition, the identification and characterization of a signaling cascade in the regulation of Rspo1 expression, a major intestinal stem cell niche signal, also opens new potential avenues for therapeutic intervention of intestinal inflammatory diseases and cancer.…”

Section: Mainmentioning

confidence: 69%

“…Wu et al ( 2021 ) recently reported discovery of a new population of disease-associated stromal cells in a mouse model of colitis. These cells are responsive to inflammation and release the Wnt agonist Rspo1 to enhance the self-renewal of colonic stem cells, thereby promoting repair of the colonic epithelium (Wu et al 2021 ) (Fig. 1 , right panel).…”

Section: Mainmentioning

confidence: 99%

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MRISCs protect colonic stem cells from inflammatory damage

Zhu

2021

Cell Regen

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Increasing evidence suggest functional roles of subepithelial mesenchymal niche cells in maintaining intestinal stem cells and in modulating the pathogenesis of various intestinal diseases in mammals. A recent study reported the discovery of a new population of stromal cells in mice termed MAP3K2-Regulated Intestinal Stromal Cells (MRISCs); these cells reside at the base of colonic crypt and function to protect colonic stem cells during colonic inflammation by expressing the Wnt agonist R-spondin1 (Rspo1).

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Section: Mainmentioning

confidence: 69%

Section: Mainmentioning

confidence: 99%

MRISCs protect colonic stem cells from inflammatory damage

Zhu

2021

Cell Regen

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“…A similar sub-population of fibroblasts associated with crypts was also recently identified in the colon ( Brugger et al, 2020 ). MAP3K2 expressing cells also reside at the base of crypts where they secrete RSPO1 ( Wu et al, 2021 ). Macrophages identified by expression of CD11b and CSF1R are also closely associated with crypts and when depleted, loss of intestinal stem cells are observed ( De Schepper et al, 2018 ; Sehgal et al, 2018 ).…”

Section: Location and Function Of Signals And Receptors During Mammalian Homeostasismentioning

confidence: 99%

Source and Impact of the EGF Family of Ligands on Intestinal Stem Cells

Abud

Chan

Jardé

2021

Front. Cell Dev. Biol.

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Epidermal Growth Factor (EGF) has long been known for its role in promoting proliferation of intestinal epithelial cells. EGF is produced by epithelial niche cells at the base of crypts in vivo and is routinely added to the culture medium to support the growth of intestinal organoids ex vivo. The recent identification of diverse stromal cell populations that reside underneath intestinal crypts has enabled the characterization of key growth factor cues supplied by these cells. The nature of these signals and how they are delivered to drive intestinal epithelial development, daily homeostasis and tissue regeneration following injury are being investigated. It is clear that aside from EGF, other ligands of the family, including Neuregulin 1 (NRG1), have distinct roles in supporting the function of intestinal stem cells through the ErbB pathway.

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“…Additionally, it is well known that Paneth cells and stromal cells, as the content of highly structured niche where the ISCs reside, are the sources of Wnts and R-spondins for ISCs. Particularly, stromal cells product Wnts, R-spondin 1 and R-spondin 3 to activate Wnt pathway in ISCs, which can maintain stem cells and prevent acute bowel injury (Greicius et al, 2018;Wu et al, 2021). It has been demonstrated that nerve system regulates IECs proliferation and differentiation through Paneth cells and stromal cells.…”

Section: Effects Of Autonomic Neurotransmitters and Receptors On The Intestinal Epithelial Cell Proliferationmentioning

confidence: 99%

Regulation of the Autonomic Nervous System on Intestine

et al. 2021

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Intestine is composed of various types of cells including absorptive epithelial cells, goblet cells, endocrine cells, Paneth cells, immunological cells, and so on, which play digestion, absorption, neuroendocrine, immunological function. Intestine is innervated with extrinsic autonomic nerves and intrinsic enteric nerves. The neurotransmitters and counterpart receptors are widely distributed in the different intestinal cells. Intestinal autonomic nerve system includes sympathetic and parasympathetic nervous systems, which regulate cellular proliferation and function in intestine under physiological and pathophysiological conditions. Presently, distribution and functional characteristics of autonomic nervous system in intestine were reviewed. How autonomic nervous system regulates intestinal cell proliferation was discussed. Function of autonomic nervous system on intestinal diseases was extensively reviewed. It might be helpful to properly manipulate autonomic nervous system during treating different intestinal diseases.

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MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche

Cited by 69 publications

References 43 publications

MRISCs protect colonic stem cells from inflammatory damage

MRISCs protect colonic stem cells from inflammatory damage

Source and Impact of the EGF Family of Ligands on Intestinal Stem Cells

Regulation of the Autonomic Nervous System on Intestine

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