MAPK activation and apoptotic alterations in hearts subjected to calcium paradox are attenuated by taurine

Xu, Yan‐Jun; Saini, Harjot K.; Zhang, Ming; Elimban, Vijayan; Dhalla, Naranjan S.

doi:10.1016/j.cardiores.2006.06.028

Cited by 51 publications

(32 citation statements)

References 50 publications

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“…Consistent with other findings, 13,14,16) our data reveals that Tau protects cardiomyocytes against H2O2-induced apoptosis. The production of LDH is an important parameter that indicates cell membrane injury.…”

Section: Discussionsupporting

confidence: 93%

“…12) Tau attenuates myocardial apoptosis induced by Ca 2+ overload or ischemia-reperfusion injury. 13) The mechanism underlying the anti-apoptotic action of Tau is related to the regulation of L-type Ca 2+ channels and Ca 2+ -ATPase-mediated Ca 2+ uptake, 14,15) which is associated with the apoptotic pathway. 16) However, the mechanisms underlying cardiac protection by Tau are not understood completely.…”

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confidence: 99%

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Taurine Protects Primary Neonatal Cardiomyocytes Against Apoptosis Induced by Hydrogen Peroxide

Wang

Liu

et al. 2018

Int. Heart J.

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SummaryThe aim of this study was to investigate the effects of taurine (Tau) on primary cultured neonatal myocardial cells treated with hydrogen peroxide (H2O2) and the underlying mechanism. Primary cardiac myocytes from neonatal Wistar rats were pre-incubated with Tau, and its effects on cell viability and expression of CaM, CaM-KII, p53, Bcl-2, and Bax were examined. Tau enhanced the viability of myocardial cells, decreased apoptosis, and alleviated the intracellular calcium overload, especially at dosages of 40 or 80 mM (P < 0.01 or P < 0.001, respectively). Moreover, Tau could inhibit the H2O2-induced decrease in CamKII and CaM expression at both the mRNA and protein levels. The pattern of CaMKII expression was consistent with that of the anti-apoptotic protein Bcl-2, but contrasted the pattern of the pro-apoptotic proteins p53 and Bax. Thus, our results show that Tau protects myocardial cells against damage caused by H2O2 exposure, suggesting that it might play a role in the mitochondrial apoptotic pathway by upregulating the expression of CaMKII to rescue myocardial cells. However, the underlying mechanism still needs to be investigated. In addition, we tested the protective effect of taurine on cardiac myocytes, and the effect of taurine on another model, specifically an animal model. (Int Heart J 2018; 59: 190-196)

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Section: Discussionsupporting

confidence: 93%

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confidence: 99%

Taurine Protects Primary Neonatal Cardiomyocytes Against Apoptosis Induced by Hydrogen Peroxide

Wang

Liu

et al. 2018

Int. Heart J.

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“…Taurine has extensively biological functions, such as stabilizing cell membrane (Paul et al, 1998), scavenging oxygen free radicals (Paul et al, 1998), regulating intracellular osmostasis (Shi et al, 2002) and maintaining intracellular Ca 2+ concentration (Molchanova et al, 2005). Recent researches have found that taurine is closely related to cardiovascular system (Militante and Lombardini, 2001;Xu et al, 2006). Exogenous administration of taurine possesses a preventive and therapeutic effect on a variety of cardiovascular diseases, such as myocardial ischemia (Takatani et al, 2004), ischemia-reperfusion injury (Suleiman et al, 1997;Tong et al, 2006), hypertension (Nara et al, 1978), cardiac hypertrophy (Azuma et al, 2000) and congestive heart failure (Huxtable and Bressler, 1974;.…”

Section: Discussionmentioning

confidence: 99%

Metabonomic study on the toxicity of Hei-Shun-Pian, the processed lateral root of Aconitum carmichaelii Debx. (Ranunculaceae)

Sun

Zhang

et al. 2008

Journal of Ethnopharmacology

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“…In addition to taurine's important role in membrane ion channels, transporters, and enzymes, contributing to modulation of intracellular Ca 2+ levels [22], it also acts as a potent antioxidant in various conditions with excessive reactive oxygen species (ROS) production [23]. In this regard, taurine supplementation has been shown to attenuate iron overload induced cardiac dysfunction via antioxidative property [24].…”

Section: Dissussionmentioning

confidence: 99%

Attenuation of Silica-Induced Pulmonary Fibroblasts Proliferation by Taurine and Niacin in Vitro

Zhou

Zeng

et al. 2009

Experimental Lung Research

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The objective of this study was to investigate potential role of taurine and niacin supplementation, and their combination, in an in vitro model of silica-induced, macrophage-mediated pulmonary fibroblast proliferation. Human monocytic cell line (THP-1 cell) was primed to differentiation into macrophages by phorbol myristate acetate (PMA). PMA-primed THP-1 cells were subjected to silicon dioxide exposure. Other PMA-primed THP-1 cells incubated with taurine and niacin concentration gradients, respectively, and then were treated with silicon dioxide for 6 hours. Collected THP-1 supernatants preconditioned with taurine and niacin gradients were added to human pulmonary WI-38 cells to evaluate proliferative activity. Transforming growth factor (TGF)-beta1 mRNA in macrophages and protein level in supernatant were determined by reverse transcriptase-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). Taurine- and niacin-preconditioned macrophages were more resistant to silica-induced TGF-beta1 up-regulation than macrophages without precondition. Furthermore, medium conditioned with supernatant from silica-exposed macrophages following taurine and niacin pretreatment could facilitate inhibition of pulmonary fibroblast proliferation. Moreover, the above effects could be accentuated by the combination of taurine and niacin. Down-regulation of TGF-beta 1 expression in macrophages by taurine and niacin could attenuate silica-induced pulmonary fibroblasts proliferation in vitro, which may be of therapeutic potential for early stage silicosis.

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MAPK activation and apoptotic alterations in hearts subjected to calcium paradox are attenuated by taurine

Cited by 51 publications

References 50 publications

Taurine Protects Primary Neonatal Cardiomyocytes Against Apoptosis Induced by Hydrogen Peroxide

Taurine Protects Primary Neonatal Cardiomyocytes Against Apoptosis Induced by Hydrogen Peroxide

Metabonomic study on the toxicity of Hei-Shun-Pian, the processed lateral root of Aconitum carmichaelii Debx. (Ranunculaceae)

Attenuation of Silica-Induced Pulmonary Fibroblasts Proliferation by Taurine and Niacin in Vitro

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