2023
DOI: 10.2147/jir.s396604
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MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury

Abstract: The mitogen-activated protein kinase signaling pathway can be activated by a variety of growth factors, cytokines, and hormones, and mediates numerous intracellular signals related to cellular activities, including cell proliferation, motility, and differentiation. It has been widely studied in the occurrence and development of inflammation and tumor. Hepatic ischemia-reperfusion injury (HIRI) is a common pathophysiological phenomenon that occurs in surgical procedures such as lobectomy and liver transplantati… Show more

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Cited by 15 publications
(15 citation statements)
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“…METTL3 de ciency resulted in further activation of the MAPK signaling pathway in I/R injury, which was evidenced by the increased phosphorylation of ERK and JNK. Activated ERK has been reported to be associated with cell proliferation and could exacerbate I/R injury, which might be attributed to the in ltration of neutrophils and cell death 44 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…METTL3 de ciency resulted in further activation of the MAPK signaling pathway in I/R injury, which was evidenced by the increased phosphorylation of ERK and JNK. Activated ERK has been reported to be associated with cell proliferation and could exacerbate I/R injury, which might be attributed to the in ltration of neutrophils and cell death 44 .…”
Section: Discussionmentioning
confidence: 99%
“…Despite the continuous development of surgical techniques and equipment improving the safety of liver surgery, hepatic ischemia/reperfusion injury (I/R) injury remains a signi cant cause of postoperative complications and mortality 2 . I/R injury is a complex pathological process involving in ammation, cellular apoptosis, and oxidative stress 3 , and is regulated by multiple signaling pathways such as the MAPK 4 , NF-κB 5 and PI3K/AKT 6,7 signaling pathways. Despite many studies on the mechanisms involved, few strategies have been translated into clinical practice 8 .…”
Section: Introductionmentioning
confidence: 99%
“…METTL3 deficiency resulted in further activation of the MAPK signaling pathway in I/R injury, which was evidenced by the increased phosphorylation of ERK and JNK. Activated ERK has been reported to be associated with cell proliferation and could exacerbate I/R injury, which might be attributed to the infiltration of neutrophils and cell death 44 .…”
Section: Discussionmentioning
confidence: 99%
“…Despite the continuous development of surgical techniques and equipment improving the safety of liver surgery, hepatic ischemia/reperfusion injury (I/R) injury remains a significant cause of postoperative complications and mortality 2 . I/R injury is a complex pathological process involving inflammation, cellular apoptosis, and oxidative stress 3 , and is regulated by multiple signaling pathways such as the MAPK 4 , NF-κB 5 and PI3K/AKT 6 , 7 signaling pathways. Despite many studies on the mechanisms involved, few strategies have been translated into clinical practice 8 .…”
Section: Introductionmentioning
confidence: 99%
“… 44 Several signal transduction pathways, including ERK/MAPK, have been found to play crucial roles in HIRI. 19 The inhibition of the ERK/MAPK pathway has a protective effect during HIRI. Carbon monoxide (CO), for instance, inhibits the expression of early pro-inflammatory and stress response genes and effectively improves HIRI by activating the CO–MEK/ERK1/2 signaling pathway.…”
Section: Discussionmentioning
confidence: 99%