MAPK signalling pathway in cancers: Olive products as cancer preventive and therapeutic agents

Peluso, Ilaria; Yarla, Nagendra Sastry; Ambra, Roberto; Pastore, Gianni; Perry, George

doi:10.1016/j.semcancer.2017.09.002

Cited by 133 publications

(89 citation statements)

References 170 publications

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“…In addition, the pathways in cancer and colorectal cancer pathway convinced that miR‐181 was indeed associated with the initiation and progression of CRC. The MAPK signaling pathway has been verified to be fundamental for regulating a series of cellular behaviors associated with tumor development, containing proliferation, invasion, apoptosis, and immune escape . Emerging evidence has supported that activation of MAPK signaling is significantly correlated with the pathogenesis, progression, and oncogenic activities of human CRC .…”

Section: Discussionmentioning

confidence: 99%

Identification of microRNA‐181 as a promising biomarker for predicting the poor survival in colorectal cancer

Peng

Yao

et al. 2019

Cancer Medicine

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Background A series of studies have investigated the vital role of microRNA‐181 (miR‐181) in the initiation and development of colorectal cancer (CRC), and demonstrated that it might be associated with the prognosis of CRC. However, inconsistent findings have hindered its clinical application. Methods A comprehensive meta‐analysis and an integrative bioinformatics analysis were carried out for concluding current available evidence, clarifying the preliminary prognostic value and unfolding the underlying biological function of miR‐181 in CRC patients. Results The findings revealed that elevated expression levels of miR‐181 were associated with significantly poorer overall survival rates (HR = 1.75, 95% CI: 1.26‐2.43, P < .05). Meanwhile, the target genes of miR‐181 were identified and enriched into several important gene ontology (GO) categories and signaling pathways including miRNAs in cancer, pathways in cancer, proteoglycans in cancer, colorectal cancer, FoxO signaling pathway, PI3K‐Akt signaling pathway, VEGF signaling pathway, HIF‐1 signaling pathway, mTOR signaling pathway, and cAMP signaling pathway, which were confirmed highly involved in the initiation and progression of CRC. In addition, the protein‐protein interaction (PPI) networks were set up by miR‐181 targets to screen hub nodes and significant modules, which were also considerably associated with the molecular pathogenesis of CRC. Conclusions The present study demonstrated that miR‐181 could be a promising biomarker with predictive value for prognosis for CRC patients. However, future studies comprising large cohorts from multicenter are warranted to further investigate the biomarker value of miR‐181.

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Section: Discussionmentioning

confidence: 99%

Identification of microRNA‐181 as a promising biomarker for predicting the poor survival in colorectal cancer

Peng

Yao

et al. 2019

Cancer Medicine

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“…pathway has a different role depending on the specific conditions [48][49][50]. Accordingly, MAPKs are a fundamental part of the inflammatory response [51].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Bee Venom on Phthalic Anhydride-Induced Atopic Dermatitis

Oh¹

2020

J Acupunct Res

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Background: Atopic dermatitis (AD) is a chronic inflammatory condition which can be studied using phthalic anhydride (PA) to induce AD. Anti-inflammatory properties of bee venom (BV) wereinvestigated to determine whether it may be a useful treatment for AD. Methods: AD was induced by applying to pical PA to 8-week-old HR-1 mice (N = 50), then treating with (0.1, 0.25, and 0.5 µg) or without topical BV. Body weight, ear thickness histology, enzymelinked immune sorbent assay (serum IgE concentrations), Western blot analysis [inducible nitric oxide synthase, cyclooxygenase-2, IκB-α, phospho-IκB-α, c-Jun N-terminal kinase (JNK), phospho-JNK, p38, phospho-p38, extra cellular signal-regulated kinase (ERK), and phospho-ERK], and the pull down assay for immunoblotting (p50), were used to measure inflammatory mediators. Results: PA + BV (0.1, 0.25, and 0.5 μg) significantly decreased ear thickness without altering body weight. IgE concentrations decreased in the PA + BV (0.5 µg)-treated groups compared with PAtreatment. Tumor necrosis factor-α, interleukin-1β, inducible nitric oxide synthase, cyclooxygenase-2, phospho-IκB-α, phospho-JNK, p38, phospho-p38, and phospho-ERK, all decreased following treatment with PA + BV compared with the PA-treatment alone. p50 was upregulated in the PA + BV-treated groups compared with the PA-treated group. Furthermore, the number of mast cells decreased in the PA + BV-treated groups compared with the PA-treated group. Epidermal thickness was significantly lower in the PA + BV-treated group compared with PA treatment alone. Conclusion: BV maybe a useful anti-inflammatory treatment for AD.

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“…The MAPKs signalling pathway is present in most cells of all organisms and is an important signal transduction pathway in eukaryotic cells, which is closely related to physiological processes such as cell proliferation, survival, differentiation and apoptosis. [30] The cells were treated with 2 lM of Meriolin1 for 15, 30 and 60 min, separately, and then, the expression of MAPKs family proteins in SH-SY5Y cells was detected. The consequences displayed that Meriolin1 can down-regulate the expression of p-ERK and increase the expression of p-JNK and p-p38 (Figure 5c).…”

Section: Effect Of Meriolin1 On the Expressions Of The Akt/mapks Signmentioning

confidence: 99%

Meriolin1 induces cell cycle arrest, apoptosis, autophagy and targeting the Akt/MAPKs pathways in human neuroblastoma SH-SY5Y cells

Wang

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Meriolins, a kind of chemical hybrid between meridianins and variolins, have lately been determined as kinase inhibitors and reportedly have antitumour activity. However, there is currently no in‐depth study for the action mechanism. This study aimed to elucidate the potentially antitumour action mechanism of Meriolin1 on human neuroblastoma (SH‐SY5Y) cells. Methods Firstly, cell viability was detected by MTT assay. Secondly, cell cycle, cell apoptosis, cell autophagy, reactive oxygen species and mitochondrial membrane potential (ΔΨm) were measured by flow cytometry. Then, cell cycle‐associated proteins, Bcl‐2 family proteins, Akt/MAPK proteins and autophagy‐associated proteins expressions were evaluated by Western blot. Bcl‐2 and Bax mRNA expressions were also evaluated by qRT‐PCR. Furthermore, cell adhesion assay and Hoechst 33258 fluorescent staining were carried out to detect the effect of Meriolin1 on cell adhesion and morphology. Finally, to gain further insight into mechanism of action of Meriolin1 to CDK protein, the molecular docking study was performed by using the CDOCKER module of DS software. Key findings Meriolin1 could exert the antitumour activity on SH‐SY5Y cells by inducing cell cycle arrest, cell autophagy, the mitochondrion‐dependent cell apoptosis and targeting the Akt/MAPKs signalling pathway. Conclusions Meriolin1 might be a promising therapeutic candidate for neuroblastoma.

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MAPK signalling pathway in cancers: Olive products as cancer preventive and therapeutic agents

Cited by 133 publications

References 170 publications

Identification of microRNA‐181 as a promising biomarker for predicting the poor survival in colorectal cancer

Identification of microRNA‐181 as a promising biomarker for predicting the poor survival in colorectal cancer

Anti-Inflammatory Effects of Bee Venom on Phthalic Anhydride-Induced Atopic Dermatitis

Meriolin1 induces cell cycle arrest, apoptosis, autophagy and targeting the Akt/MAPKs pathways in human neuroblastoma SH-SY5Y cells

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