Mapping and Characterization of the Dominant Black Colour Locus in Sheep

Våge, Dag Inge; Fleet, M. R.; Ponz, R.; Olsen, Ranveig T; Monteagudo, L. V.; Tejedor, María Teresa; Arruga, M.V.; Gagliardi, R.; Postiglioni, A.; Nattrass, G. S.; Klungland, Helge

doi:10.1046/j.1600-0749.2003.00090.x

Cited by 52 publications

(40 citation statements)

References 29 publications

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“…3). But, more importantly, the clear and statistically significant association between the MC1R variants and plumage color strongly suggests that the Asp119Asn mutation contributes to the expression of the melanic plumage of Santa Ana birds and appears to be dominant, since heterozygous individuals are melanic in plumage (e.g., Kijas et al 1998;Theron et al 2001;Våge et al 2003).…”

Section: Genetics Of Plumage Differencesmentioning

confidence: 99%

“…First, breeding experiments indicate that the identical amino acid substitution at the homologous site cosegregates with melanism in several strains of sheep (Våge et al 1999(Våge et al , 2003 and pigs (Kijas et al 1998). Second, amino acid 119 is in the third transmembrane of MC1R and part of a negatively charged pocket that is crucial for binding with the positively charged asparagine residue of its agonist (Lu et al 1998).…”

Section: Genetics Of Plumage Differencesmentioning

confidence: 99%

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Difference in Plumage Color Used in Species Recognition between Incipient Species Is Linked to a Single Amino Acid Substitution in the Melanocortin‐1 Receptor

Uy¹,

Moyle²,

Filardi³

et al. 2009

The American Naturalist

134

112

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JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. abstract: Many studies demonstrate that differences in mating signals are used by incipient species in recognizing potential mates or sexual competitors (i.e., species recognition). Little is known, however, about the genetic changes responsible for these differences in mating signals. Populations of the Monarcha castaneiventris flycatcher vary in plumage color across the Solomon Islands, with a subspecies on Makira Island having chestnut bellies and blue-black upper parts (Monarcha castaneiventris megarhynchus) and a subspecies on neighboring satellite islands being entirely blue-black (melanic; Monarcha castaneiventris ugiensis). Here we show that a single nonsynonymous point mutation in the melanocortin-1 receptor (MC1R) gene is present in all melanic birds from one island (Santa Ana) but absent in all chestnut-bellied birds from Makira Island, implicating this mutation in causing melanism. Birds from a second satellite island (Ugi) do not show the same perfect association between this MC1R variant and plumage color, suggesting an alternative mechanism for melanism on this island. Finally, taxidermic mount presentation experiments in Makira (chestnut) and Santa Ana (melanic) suggest that the plumage difference mediates species recognition. Assuming that the signals used in species recognition are also used in mutual mate choice, our results indicate that a single amino acid substitution contributes to speciation.

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Section: Genetics Of Plumage Differencesmentioning

confidence: 99%

Section: Genetics Of Plumage Differencesmentioning

confidence: 99%

Difference in Plumage Color Used in Species Recognition between Incipient Species Is Linked to a Single Amino Acid Substitution in the Melanocortin‐1 Receptor

Uy¹,

Moyle²,

Filardi³

et al. 2009

The American Naturalist

134

112

View full text Add to dashboard Cite

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“…This last is of special interest to breeders since it is impossible to distinguish by eye a sheep with recessive alleles causing black fur colour. This is the reason why black lambs are sometimes born in flocks of white sheep (Våge et al, 2003).…”

Section: The Melanocortin 1 Receptor (Mc1r) Gene and The Agouti Signamentioning

confidence: 99%

“…Våge et al (2003) mapped MC1R to ovine chromosome 14 and identified the two missense mutations, i.e. Met > Lys mutation at position 73 and the Asp > Asn mutation at position 121, which results in a dominant black effect (E D allele) (Våge et al, 1999(Våge et al, , 2003.…”

Section: The Melanocortin 1 Receptor (Mc1r) Gene and The Agouti Signamentioning

confidence: 99%

Genetic background of coat colour in sheep

et al. 2018

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Abstract. The coat colour of animals is an extremely important trait that affects their behaviour and is decisive for survival in the natural environment. In farm animal breeding, as a result of the selection of a certain coat colour type, animals are characterized by a much greater variety of coat types. This makes them an appropriate model in research in this field. A very important aspect of the coat colour types of farm animals is distinguishing between breeds and varieties based on this trait. Furthermore, for the sheep breeds which are kept for skins and wool, coat/skin colour is an important economic trait. Until now the study of coat colour inheritance in sheep proved the dominance of white colour over pigmented/black coat or skin and of black over brown.

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“…To date, all investigations for genes associated with sheep coat colours have used linkage (for example, Våge et al, 2003;Beraldi et al, 2006) and candidate gene analytic methods (for example, Loehr Norris and Whan, 2008;Gratten et al, 2010). Whereas linkage analysis is a useful tool for identifying rare genetic variants with relatively large phenotypic effects that follow Mendelian laws of inheritance, GWAS is the method of choice for detecting common genetic variants associated with phenotypic variation (for example, Kayser et al, 2008), and a higher resolution can be achieved.…”

Section: Introductionmentioning

confidence: 99%

A genome-wide scan study identifies a single nucleotide substitution in ASIP associated with white versus non-white coat-colour variation in sheep (Ovis aries)

Tiirikka

Kantanen

2013

Heredity

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In sheep, coat colour (and pattern) is one of the important traits of great biological, economic and social importance. However, the genetics of sheep coat colour has not yet been fully clarified. We conducted a genome-wide association study of sheep coat colours by genotyping 47 303 single-nucleotide polymorphisms (SNPs) in the Finnsheep population in Finland. We identified 35 SNPs associated with all the coat colours studied, which cover genomic regions encompassing three known pigmentation genes (TYRP1, ASIP and MITF) in sheep. Eighteen of these associations were confirmed in further tests between white versus non-white individuals, but none of the 35 associations were significant in the analysis of only non-white colours. Across the tests, the s66432.1 in ASIP showed significant association (P ¼ 4.2 Â 10 À11 for all the colours; P ¼ 2.3 Â 10 À11 for white versus non-white colours) with the variation in coat colours and strong linkage disequilibrium with other significant variants surrounding the ASIP gene. The signals detected around the ASIP gene were explained by differences in white versus non-white alleles. Further, a genome scan for selection for white coat pigmentation identified a strong and striking selection signal spanning ASIP. Our study identified the main candidate gene for the coat colour variation between white and non-white as ASIP, an autosomal gene that has been directly implicated in the pathway regulating melanogenesis. Together with ASIP, the two other newly identified genes (TYRP1 and MITF) in the Finnsheep, bordering associated SNPs, represent a new resource for enriching sheep coat-colour genetics and breeding.

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Mapping and Characterization of the Dominant Black Colour Locus in Sheep

Cited by 52 publications

References 29 publications

Difference in Plumage Color Used in Species Recognition between Incipient Species Is Linked to a Single Amino Acid Substitution in the Melanocortin‐1 Receptor

Difference in Plumage Color Used in Species Recognition between Incipient Species Is Linked to a Single Amino Acid Substitution in the Melanocortin‐1 Receptor

Genetic background of coat colour in sheep

A genome-wide scan study identifies a single nucleotide substitution in ASIP associated with white versus non-white coat-colour variation in sheep (Ovis aries)

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