Mapping cellular senescence networks in human diabetic foot ulcers

Yu, Grace T; Monie, Dileep D.; Khosla, Sundeep; Tchkonia, Tamar; Kirkland, James L.; Wyles, Saranya P.

doi:10.1007/s11357-023-00854-x

Cited by 4 publications

(2 citation statements)

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“…Senescent cell accumulation has also been found in diabetic complications, such as diabetic nephropathy, retinopathy, and cardiovascular disease ( Oubaha et al, 2016 ; Xiong and Zhou, 2019 ; Tai et al, 2022 ). Several studies have reported on the contribution of senescent cells to chronic wounds and diabetic ulcers ( Wilkinson et al, 2019 ; Wei et al, 2023 ; Yu et al, 2023 ).…”

Section: Role Of Cellular Senescence In Wound Healing In Diabetic Skinmentioning

confidence: 99%

“…In a patient with a diabetic ulcer, histological analysis showed that the expression of SA-β-gal and p16 was upregulated in the dermis ( Wei et al, 2023 ). RNA-seq analysis of whole-skin biopsies from patients with diabetic ulcers revealed increased senescence and SASP markers, including CDKN1A, C-X-C motif chemokine ligand 8 (CXCL8), insulin-like growth factor binding protein 2 (IGFBP2), IL1A, MMP10, serine protease inhibitor clade E member 1 (SERPINE1), and TGF-A ( Yu et al, 2023 ). These studies suggest that senescence is a mediator of diabetic ulcer pathogenesis; however, the cell type involved in this pathology remains unclear.…”

Section: Role Of Cellular Senescence In Wound Healing In Diabetic Skinmentioning

confidence: 99%

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Cellular senescence and wound healing in aged and diabetic skin

Kita,

Yamamoto,

Saito

et al. 2024

Front. Physiol.

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Cellular senescence is a biological mechanism that prevents abnormal cell proliferation during tissue repair, and it is often accompanied by the secretion of various factors, such as cytokines and chemokines, known as the senescence-associated secretory phenotype (SASP). SASP-mediated cell-to-cell communication promotes tissue repair, regeneration, and development. However, senescent cells can accumulate abnormally at injury sites, leading to excessive inflammation, tissue dysfunction, and intractable wounds. The effects of cellular senescence on skin wound healing can be both beneficial and detrimental, depending on the condition. Here, we reviewed the functional differences in cellular senescence that emerge during wound healing, chronic inflammation, and skin aging. We also review the latest mechanisms of wound healing in the epidermis, dermis, and subcutaneous fat, with a focus on cellular senescence, chronic inflammation, and tissue regeneration. Finally, we discuss the potential clinical applications of promoting and inhibiting cellular senescence to maximize benefits and minimize detrimental effects.

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