Mapping choroidal thickness in patients with type 2 diabetes

Abadia, Beatriz; Bartol-Puyal, Francisco de Asís; Calvo, Pilar; Verdes, Guayente; Isanta, Carlos; Júlvez, Luis Pablo

doi:10.1016/j.jcjo.2019.06.009

Cited by 12 publications

(6 citation statements)

References 26 publications

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“…Several studies that have also utilized the 900-grid algorithm to analyze CT distribution divided the macular region into five zones according to the CT in 900 grids but did not investigate the inter-individual variation. 20 , 21 Therefore, the potential mechanisms of inter-individual choroidal variation remain uncertain and deserve further exploration in the future.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a 900-grid analysis algorithm for CT has been developed for Triton Multimodal SS-OCT (Topcon Healthcare, Tokyo, Japan), allowing for nuanced evaluation of the topographic features of macular CT. 20 , 21 In this study, we investigated the relationship between CT in each of the 900 grids and various CT-associated factors to map CT variations. Additionally, we constructed distributions for the coefficient of variance (CoV), coefficient of determination (CoD), and coefficient of variance unexplained (CoVU) across the 900 grids.…”

Section: Introductionmentioning

confidence: 99%

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Inter-Individual Topographic Variation of Choroidal Thickness in Healthy Eyes on Swept-Source Optical Coherence Tomography

Jiang,

Lin,

Lin

et al. 2024

Trans. Vis. Sci. Tech.

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Purpose To investigate the topographic characters of inter-individual variations of the macular choroidal thickness (CT). Methods This was a retrospective study. Macular CT data for 900 0.2 × 0.2-mm grids from 410 healthy eyes were collected from swept-source optical coherence tomography. Following the analysis of factors associated with mean CT, the β-coefficients of the included associated factors in each grid were summarized for choroidal thickness changes analysis. Additionally, the coefficient of variance (CoV), coefficient of determination (CoD), and coefficient of variance unexplained (CoVU) for CT were calculated in each individual grid to investigate the inter-individual choroidal variations pattern. Results Sex (β = −17.26, female vs. male), age (β = −1.61, per 1 year), and axial length (β = −18.62, per 1 mm) were associated with mean macular CT. Females had a thinner choroid in all 900 grids (0.5–26.9 µm). As age increased, the CT noticeably decreased (8.74–19.87 µm per 10 years) in the temporal regions. With axial length elongation, the thinning (7.94–24.91 µm per 1 mm) was more evident in subfoveal and nasal regions. Both the CoV (34.69%–58.00%) and CoVU (23.05%–40.78%) were lower in the temporal regions, whereas the CoD (18.41%–39.66%) was higher in the temporal regions. Conclusions Choroidal thinning is more predominant in the subfoveal and nasal regions with axial length elongation, but in the temporal region with aging. The inter-individual variation of CT is higher and less determined by sex, age, or axial length in the nasal regions. Translational Relevance Topographic variation should be considered when interpreting choroidal thickness.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inter-Individual Topographic Variation of Choroidal Thickness in Healthy Eyes on Swept-Source Optical Coherence Tomography

Jiang,

Lin,

Lin

et al. 2024

Trans. Vis. Sci. Tech.

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“…The changes in CTh have been confirmed in glaucoma [ 19 ], age-related macular degeneration [ 21 ], uveitis [ 18 ], retinitis pigmentosa [ 20 ] and myopia [ 17 ]. Similarly, there is evidence to support the effect of lupus nephritis [ 22 ], familial hypercholesterolaemia [ 23 ], diabetes mellitus [ 24 ], hypertension [ 25 ], cardiovascular diseases [ 3 , 26 ] on CTh. However, little attention has been paid to date to assessing CTh changes in paediatric cardiovascular disorders leading to heart failure, such as cardiomyopathy.…”

Section: Introductionmentioning

confidence: 99%

Choroidal thickness changes in children with chronic heart failure due to dilated cardiomyopathy

et al. 2021

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Purpose To evaluate choroidal thickness (CTh) in children with chronic heart failure (CHF) secondary to dilated cardiomyopathy (DCM) using spectral domain optical coherence tomography (SD-OCT) and to compare their values to those of healthy children. Methods Sixty eyes of thirty children (mean age 9.9 ± 3.57 years) with chronic heart failure (left ventricular ejection fraction, LVEF ≤ 55%) due to DCM lasting for over 6 months were prospectively enrolled. The control group consisted of 30 age- (mean age 10.16 ± 3.42 years) and sex-matched healthy children. All participants underwent transthoracic echocardiography with LVEF measured using the Simpson method and had the blood serum level of N-terminal-pro-brain natriuretic peptide marker (NT-proBNP) determined. All children underwent SD-OCT and had subfoveal choroidal thickness (SFCTh) and CTh measured at 1500 µm (μm) nasally, temporally, superiorly and inferiorly from the fovea in both eyes by two investigators. Results CTh at all locations was statistically significantly lower in children with DCM compared to the control group. Mean CTh in the group with CHF compared to the control group were (304.03 vs. 369.72 μm, p < 0.05) at the subfoveal location, (245.87 vs. 284 μm, p < 0.05) 1500 μm nasally from the fovea, (291.5 vs. 355.95 μm, p < 0.05) 1500 μm temporally from the fovea, (303.98 vs. 357.58 μm, p < 0.05) 1500 μm superiorly from the fovea and (290.92 vs. 344.96 μm, p < 0.05) 1500 μm inferiorly from the fovea. The average difference CTh between the study groups ranged from 38.13 to 65.69 μm at individual locations. In both groups, CTh was the thickest at subfoveal location (304.03 vs. 369.72 μm, p < 0.05) and the thinnest was 1500 μm nasally from the fovea (262.37 vs. 336.87 μm, p < 0.05). There was no correlation between CTh and age, gender, biometry and refractive error. No correlation was found between CTh and LVEF and NT-proBNP. Conclusion Patients with CHF due to DCM had a thinner CTh at all measured locations. The results of our research indicate that CHF affects CTh and this parameter may be very helpful in monitoring the clinical course of the disease in children with DCM.

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“…Successive improvement in technology and instrumentation provided the possibility of using enhanced depth imaging (EDI) using spectral domain optical coherence tomography to study the choroid. This method has opened a new window in understanding choroidal physiopathology in normality and disease [23][24][25][26][27][28][29][30]. OCT methods have rapidly improved, and angiography has been included, thus giving rise to OCT-A, which has revolutionized the evaluation of retinal and choroidal perfusion.…”

Section: Introductionmentioning

confidence: 99%

Short-Term Effects of Dark Chocolate on Retinal and Choriocapillaris Perfusion in Young, Healthy Subjects Using Optical Coherence Tomography Angiography

et al. 2020

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1) Aim: Contrasting results have been published on the effect of dark chocolate on visual function. The aim of this study was to evaluate retinal and choriocapillaris perfusion, using optical coherence tomography angiography (OCT-A), and visual function in healthy subjects following dark chocolate ingestion. (2) Methods: This prospective randomized study was carried out on 18 healthy young subjects at the St. Andrea Hospital, Sapienza, University of Rome. Visual acuity assessment and a complete ophthalmologic examination were carried out at baseline. In session one, each subject was randomized to eat either a 100 g dark chocolate bar or a 100 g white chocolate bar. In session two, the opposite chocolate was given to each participant. OCT-A and best corrected visual acuity (BCVA) were performed before the chocolate was eaten and repeated 1, 2, and 3 h after that. Retinal vessel density and choriocapillaris flow area were assessed. (3) Results: 18 patients with a mean (SD) age of 26.3 (1.5) years were included. No significant differences between dark or white chocolate were found when evaluating foveal density (%), whole density (%), choriocapillaris flow area, and BCVA. (4) Conclusions: Dark chocolate did not result in significant changes in retinal perfusion and choriocapillaris flow area. However, given the results of other studies showing the positive effects of flavonoids on visual function, further studies are warranted using pure chocolate without other components such as caffeine that can potentially affect results. Furthermore, we cannot rule out the possible benefits of higher doses of flavonoids in dietary supplementation over a more extended period and in a larger patient population.

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Mapping choroidal thickness in patients with type 2 diabetes

Cited by 12 publications

References 26 publications

Inter-Individual Topographic Variation of Choroidal Thickness in Healthy Eyes on Swept-Source Optical Coherence Tomography

Inter-Individual Topographic Variation of Choroidal Thickness in Healthy Eyes on Swept-Source Optical Coherence Tomography

Choroidal thickness changes in children with chronic heart failure due to dilated cardiomyopathy

Short-Term Effects of Dark Chocolate on Retinal and Choriocapillaris Perfusion in Young, Healthy Subjects Using Optical Coherence Tomography Angiography

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