Mapping current research and identifying hotspots on mesenchymal stem cells in cardiovascular disease

Abstract

Background Mesenchymal stem cells (MSCs) have important research value and broad application prospects in the cardiovascular disease. This study provides information on the latest progress, evolutionary path, frontier research hotspots, and future research developmental trends in this field. Methods A knowledge map was generated by CiteSpace and VOSviewer analysis software based on data obtained from the literature on MSCs in the cardiovascular field. Results The USA and China ranked at the top in terms of the percentage of articles, accounting for 34.306% and 28.550%, respectively. The institution with the highest number of research publications in this field was the University of Miami, followed by the Chinese Academy of Medical Sciences and Harvard University. The research institution with the highest ACI value was Harvard University, followed by the Mayo Clinic and the University of Cincinnati. The top three subjects in terms of the number of published articles were cell biology, cardiovascular system cardiology, and research experimental medicine. The journal with the most publications in this field was Circulation Research, followed by Scientific Reports and Biomaterials. The direction of research on MSCs in the cardiovascular system was divided into four parts: (1) tissue engineering, scaffolds, and extracellular matrix research; (2) cell transplantation, differentiation, proliferation, and signal transduction pathway research; (3) assessment of the efficacy of stem cells from different sources and administration methods in the treatment of acute myocardial infarction, myocardial hypertrophy, and heart failure; and (4) exosomes and extracellular vesicles research. Tissue research is the hotspot and frontier in this field. Conclusion MSC research has presented a gradual upward trend in the cardiovascular field. Multidisciplinary intersection is a characteristic of this field. Engineering and materials disciplines are particularly valued and have received attention from researchers. The progress in multidisciplinary research will provide motivation and technical support for the development of this field.

Knowledge Domain and Emerging Trends in Ferroptosis Research: A Bibliometric and Knowledge-Map Analysis

“…That which other methods, such as traditional review, meta-analysis, or experiment research, cannot perform. According to the strengths, it is becoming increasingly important in evaluating research trends and formulating guidelines ( 24 ). Therefore, bibliometrics is suitable for evaluating and overviewing ferroptosis research.…”

Structural and Temporal Dynamics of Mesenchymal Stem Cells in Liver Diseases From 2001 to 2021: A Bibliometric Analysis

“…Contributions from different nations, organizations, experts, and publications can be compared to describe and project future advancements in a certain study topic ( 14 ). Many scholars have used bibliometrics analysis in various fields of medicine, such as psychological disorders ( 15 ), cardiovascular disease ( 16 ), endocrine disease ( 17 ), digestive system neoplasms ( 18 ), ferroptosis ( 13 ), and biological signaling molecule ( 19 ). It is becoming increasingly important in assessing hotspots frontiers and formulating guidelines between MSCs and liver disease research.…”

Global research status and hot trends in stem cells therapy for Intervertebral disc degeneration: A bibliometric and clinical study analysis

“…Different from traditional citation statistics, it can account for links between documents and recognize knowledge structures and rising trends ( Wang et al, 2021 ). Because of its distinctive advantages, it has become especially important in evaluating hotspots in literature and developing further projects ( Chen et al, 2020 ). This study provides a systematic summary of the research on SCs in IDD, looking for its research frontiers, hotspots and trends, and reviewing the characteristics of clinical trials, summarising their development process and visualising them, which can provide a reference for further research in the future.…”