Mapping insulin non‐covalent interactions with natural polysaccharides by hydrogen/deuterium exchange mass spectrometry

Abstract

The studies reported here demonstrated the capabilities of mass spectrometry techniques and HDX methods to obtain useful information toward the flexibility and the behavior of native insulin in the presence of natural polysaccharides, and could provide insights to study the behavior of pharmaceutical formulations. Copyright © 2016 John Wiley & Sons, Ltd.