Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophrenia

Hare, Stephanie; Du, Xiaoming; Adhikari, Bhim M.; Chen, Shuo; Chen, Mo; Summerfelt, Ann; Kvarta, Mark D.; García, Laura Cruz; Kochunov, Peter; Hong, L. Elliot

doi:10.1016/j.nicl.2021.102688

Cited by 5 publications

(3 citation statements)

References 56 publications

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“…71 TMS depolarizes cortical neurons, and the activity expands to all connected areas. This effect of TMS would be the basis for rehabilitation therapies, 72 being able to make interventions at the cortical level, producing an effect in deeper areas. 73 In this context, it is relevant to consider individual differences in functional brain connectivity, which could interfere with the effects of TMS.…”

Section: Discussionmentioning

confidence: 99%

Lateral Prefrontal Theta Oscillations Causally Drive a Computational Mechanism Underlying Conflict Expectation and Adaptation

Martínez-Molina,

Valdebenito-Oyarzo,

Soto-Icaza

et al. 2024

Preprint

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Adapting our behavior to environmental demands relies on our capacity to perceive and manage potential conflicts within our surroundings. While evidence implicates the involvement of the lateral prefrontal cortex and theta oscillations in detecting conflict stimuli, their roles in conflict expectation remain elusive. Consequently, the exact computations and neural mechanisms underlying these cognitive processes still need to be determined. To address this gap, we employed an integrative approach involving cognitive computational modeling, fMRI, TMS, and EEG. Our results revealed a computational process underlying conflict expectation, which correlated with activity in the superior frontal gyrus (SFG). Furthermore, rhythmic TMS in the theta range applied over the SFG, but not over the inferior frontal junction, induced endogenous theta activity, enhancing computations associated with conflict expectation. These findings provide compelling evidence for the causal involvement of SFG theta activity in learning and allocating cognitive resources to address forthcoming conflict stimuli.

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Section: Discussionmentioning

confidence: 99%

Lateral Prefrontal Theta Oscillations Causally Drive a Computational Mechanism Underlying Conflict Expectation and Adaptation

Martínez-Molina,

Valdebenito-Oyarzo,

Soto-Icaza

et al. 2024

Preprint

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“…ISI: 100 ms CSP: 140% of RMT Magstim 200. figure-of-eight coil Right APB Hare et al 56 23 (7) 29 (14) 37 (13.5) 33.3 (9.2) SSD SICI CS: 80%. TS: 120% of RMT.…”

Section: Methodsmentioning

confidence: 99%

Excitation/inhibition imbalance in schizophrenia: a meta-analysis of inhibitory and excitatory TMS-EMG paradigms

Lányi,

Koleszár,

Schulze Wenning

et al. 2024

Schizophr

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Cortical excitation-inhibition (E/I) imbalance is a potential model for the pathophysiology of schizophrenia. Previous research using transcranial magnetic stimulation (TMS) and electromyography (EMG) has suggested inhibitory deficits in schizophrenia. In this meta-analysis we assessed the reliability and clinical potential of TMS-EMG paradigms in schizophrenia following the methodological recommendations of the PRISMA guideline and the Cochrane Handbook. The search was conducted in three databases in November 2022. Included articles reported Short-Interval Intracortical Inhibition (SICI), Intracortical Facilitation (ICF), Long-Interval Intracortical Inhibition (LICI) and Cortical Silent Period (CSP) in patients with schizophrenia and healthy controls. Meta-analyses were conducted using a random-effects model. Subgroup analysis and meta-regressions were used to assess heterogeneity. Results of 36 studies revealed a robust inhibitory deficit in schizophrenia with a significant decrease in SICI (Cohen’s d: 0.62). A trend-level association was found between SICI and antipsychotic medication. Our findings support the E/I imbalance hypothesis in schizophrenia and suggest that SICI may be a potential pathophysiological characteristic of the disorder.

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“…For each SICI trial, a subthreshold conditioning stimulus (80% RMT) was followed by a suprathreshold stimulus (TS). Owing to the large interindividual variability in cortical inhibition exploration, 67 we used a standard method 56 , 58 , 68 by acquiring 12 trials for each interstimulus interval and averaged the 24 recorded peak-to-peak amplitudes to obtain the SICI amplitude. Interstimulus intervals of 1 and 3 ms share similar cortical inhibition patterns.…”

Section: Methodsmentioning

confidence: 99%

The pathobiology of psychomotor slowing in psychosis: altered cortical excitability and connectivity

Lefebvre,

Gehrig,

Nadesalingam

et al. 2023

Brain

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Psychomotor slowing is a frequent symptom of schizophrenia. Short-interval intracortical inhibition assessed by transcranial magnetic stimulation demonstrated inhibitory dysfunction in schizophrenia. The inhibitory deficit results from additional noise during information processing in the motor system in psychosis. Here, we tested whether cortical inhibitory dysfunction was linked to psychomotor slowing and motor network alterations. In this cross-sectional study, we included 60 patients with schizophrenia and psychomotor slowing determined by the Salpetriere Retardation Rating Scale, 23 patients without slowing and 40 healthy controls, we acquired single and double-pulse transcranial magnetic stimulation effects from the left primary motor cortex, resting-state functional connectivity, and diffusion imaging on the same day. Groups were compared on resting motor threshold, amplitude of the motor evoked potentials, as well as short-interval intracortical inhibition. Regression analyses calculated the association between motor evoked potential amplitudes or cortical inhibition with seed-based resting-state functional connectivity from the left primary motor cortex and fractional anisotropy at whole brain level and within major motor tracts. In patients with schizophrenia and psychomotor slowing, we observed lower amplitudes of motor evoked potentials, while the short-interval intracortical inhibition/motor evoked potentials amplitude ratio was higher than in healthy controls, suggesting lower cortical inhibition in these patients. Patients without slowing also had lower amplitudes of motor evoked potentials. Across the combined patient sample, cortical inhibition deficits were linked to more motor coordination impairments. In patients with schizophrenia and psychomotor slowing, lower amplitudes of motor evoked potentials were associated with lower fractional anisotropy in motor tracts. Moreover, resting-state functional connectivity between the primary motor cortex, the anterior cingulate cortex and the cerebellum increased with lower cortical inhibition. In contrast, in healthy controls and patients without slowing, stronger cortical inhibition was linked to lower resting-state functional connectivity between the left primary motor cortex and premotor or parietal cortices. Psychomotor slowing in psychosis is linked to less cortical inhibition and aberrant functional connectivity of the primary motor cortex. Higher neural noise in the motor system may drive psychomotor slowing and thus may become a treatment target.

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Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophrenia

Cited by 5 publications

References 56 publications

Lateral Prefrontal Theta Oscillations Causally Drive a Computational Mechanism Underlying Conflict Expectation and Adaptation

Lateral Prefrontal Theta Oscillations Causally Drive a Computational Mechanism Underlying Conflict Expectation and Adaptation

Excitation/inhibition imbalance in schizophrenia: a meta-analysis of inhibitory and excitatory TMS-EMG paradigms

The pathobiology of psychomotor slowing in psychosis: altered cortical excitability and connectivity

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