Mapping the Arab genome

Mbarek, Hamdi; Ismail, Said I.

doi:10.1038/s41588-022-01239-0

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…To advance the field of PGx, international collaboration is crucial. Qatar is actively encouraging global engagement with its data, and the findings from the research initiatives are publicly accessible for specialists and researchers worldwide ( 37 , 59 ). Collaborations with institutions like Genomics England allow for cross-analysis with national datasets, contributing to a broader understanding of genetic variations across populations.…”

Section: Educational Activities To Support Pgx Implementation In Qatarmentioning

confidence: 99%

Forging the path to precision medicine in Qatar: a public health perspective on pharmacogenomics initiatives

Bastaki,

Velayutham,

Irfan

et al. 2024

Front. Public Health

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Pharmacogenomics (PGx) is an important component of precision medicine that promises tailored treatment approaches based on an individual’s genetic information. Exploring the initiatives in research that help to integrate PGx test into clinical setting, identifying the potential barriers and challenges as well as planning the future directions, are all important for fruitful PGx implementation in any population. Qatar serves as an exemplar case study for the Middle East, having a small native population compared to a diverse immigrant population, advanced healthcare system, national genome program, and several educational initiatives on PGx and precision medicine. This paper attempts to outline the current state of PGx research and implementation in Qatar within the global context, emphasizing ongoing initiatives and educational efforts. The inclusion of PGx in university curricula and healthcare provider training, alongside precision medicine conferences, showcase Qatar’s commitment to advancing this field. However, challenges persist, including the requirement for population specific implementation strategies, complex genetic data interpretation, lack of standardization, and limited awareness. The review suggests policy development for future directions in continued research investment, conducting clinical trials for the feasibility of PGx implementation, ethical considerations, technological advancements, and global collaborations to overcome these barriers.

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Section: Educational Activities To Support Pgx Implementation In Qatarmentioning

confidence: 99%

Forging the path to precision medicine in Qatar: a public health perspective on pharmacogenomics initiatives

Bastaki,

Velayutham,

Irfan

et al. 2024

Front. Public Health

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Leveraging diverse genomic data to guide equitable carrier screening: Insights from gnomAD v.4.1.0

Schmitz,

Bashar,

Soman

et al. 2024

The American Journal of Human Genetics

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Clinical utility of polygenic scores for cardiometabolic disease in Arabs

Shim,

Kuwahara,

Chen

et al. 2023

Nat Commun

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Arabs account for 5% of the world population and have a high burden of cardiometabolic disease, yet clinical utility of polygenic risk prediction in Arabs remains understudied. Among 5399 Arab patients, we optimize polygenic scores for 10 cardiometabolic traits, achieving a performance that is better than published scores and on par with performance in European-ancestry individuals. Odds ratio per standard deviation (OR per SD) for a type 2 diabetes score was 1.83 (95% CI 1.74–1.92), and each SD of body mass index (BMI) score was associated with 1.18 kg/m2 difference in BMI. Polygenic scores associated with disease independent of conventional risk factors, and also associated with disease severity—OR per SD for coronary artery disease (CAD) was 1.78 (95% CI 1.66–1.90) for three-vessel CAD and 1.41 (95% CI 1.29–1.53) for one-vessel CAD. We propose a pragmatic framework leveraging public data as one way to advance equitable clinical implementation of polygenic scores in non-European populations.

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Mapping the Arab genome

Cited by 5 publications

References 17 publications

Forging the path to precision medicine in Qatar: a public health perspective on pharmacogenomics initiatives

Forging the path to precision medicine in Qatar: a public health perspective on pharmacogenomics initiatives

Leveraging diverse genomic data to guide equitable carrier screening: Insights from gnomAD v.4.1.0

Clinical utility of polygenic scores for cardiometabolic disease in Arabs

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