Mapping the Cerebrovascular Abnormality in Transgenic Alzheimer’s Disease (AD) Mice with deep-learning-based super-resolution cerebral blood volume (CBV)-MRI
Xiaoqing Alice Zhou,
Xiaochen Liu,
Hongwei Bran Li
et al.
Abstract:To measure the brain-wide vascular density (VD) alteration in degenerated brains with Alzheimer's Disease (AD), deep learning-based super-resolution approach was developed to assist the segmentation of micro-vessels from the Monocrystalline Iron Oxide Nanoparticle (MION)-based CBV MRI images of transgenic mouse brains. Iron-induced T2* amplification effect well separated micro-vessels with tens of microns from capillary-enriched parenchyma voxels, enabling vascular compartment-specific VD differential analysis… Show more
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