Due to their simple synthesis method and excellent properties, such as superior adsorption and regeneration capabilities, with a large surface area and tunable pores, metal-organic frameworks (MOFs) have emerged as a suitable option for wastewater treatment. Although an exponential growth in MOF literature has been observed in recent years, conducting a quantitative literature analysis of MOF application in wastewater treatment is a novelty. To fill this gap, a total of 1187 relevant publications were extracted from the Web of Science, published during the last 50 years, and analyzed using bibliometric and content analysis techniques. A bibliometric analysis was conducted to reveal growing publication trends, leading journals, prolific countries, and organizations; whereas, a content analysis was used to highlight key research themes and hot topics in this field. The analyses revealed that there is a strong international collaboration among authors, countries, and organizations. Chemical Engineering Journal, Journal of Hazardous Materials, and Journal of Environmental Chemical Engineering are the most prolific journals in this field. Furthermore, the use of MOFs for removing antibiotics from wastewater was identified as a recent hot topic. In addition, performance enhancements of MOFs, in terms of a higher adsorption capacity and water stability, were identified as topics of great interest. To cater to these issues, the application of graphene, graphene oxides, nanoparticles, and quantum dots was also observed in the research fronts in this field.