Mapping the hand, foot and face representations in the primary motor cortex — Retest reliability of neuronavigated TMS versus functional MRI

Weiss, Carolin; Nettekoven, Charlotte; Rehme, Anne Kathrin; Neuschmelting, Volker; Eisenbeis, A.; Goldbrunner, Roland; Grefkes, Christian

doi:10.1016/j.neuroimage.2012.10.046

Cited by 131 publications

(155 citation statements)

References 91 publications

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“…Therefore, we have no direct information on the topographical match of the TMS hotspots in M1 HAND and the fMRI defined M1HAND representations used for hCMF tractography. Although previous studies reported Euclidean differences between navigated TMS hotspots and fMRI local activation maxima of about 10 mm (Weiss et al 2013;Ruohonen and Karhu 2010), we do not think that lack of this information is critical in the present study, as we found significant correlations of both S-IHI and FAhCMF with vc-BTC performance, signifying that both measures very likely targeted the same transcallosal pathway relevant for visually guided bimanual coordination.…”

Section: Visually Cued Bimanual Temporal Coordination (Vc-btc) Perforcontrasting

confidence: 48%

Callosal anatomical and effective connectivity between primary motor cortices predicts visually cued bimanual temporal coordination performance

et al. 2015

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Default in-phase coupling of hand movements needs to be suppressed when temporal coordination is required for out-of-phase bimanual movements. There is lack of knowledge on how the brain overrides these default in-phase movements to enable a required interval of activity between hands. We used a visually cued bimanual temporal coordination (vc-BTC) paradigm with a constant rhythmical time base of 1 s, to test the accuracy of in-phase and out-of-phase (0.1, 0.2,…,0.9) finger tapping. We hypothesized that (1) stronger anatomical and effective interhemispheric connectivity between the hand areas of the primary motor cortex (M1HAND) predict higher temporal offsets between hands in the out-of-phase conditions of the vc-BTC; (2) patients with relapsing-remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) have reduced interhemispheric connectivity and altered between-hand coupling. Anatomical connectivity was determined by fractional anisotropy of callosal hand motor fibers (FA-hCMF). Effective connectivity was probed by short interval interhemispheric inhibition (S-IHI) using paired-coil transcranial magnetic stimulation (TMS). In healthy subjects, higher FA-hCMF and S-IHI correlated with higher temporal offsets between hands in the out-of-phase conditions of the tapping test. FA-hCMF was reduced in patients with RRMS but not in CIS, while S-IHI was reduced in both patient groups. These abnormalities were associated with smaller temporal offsets between hands leading to less deviation from the required phasing in the out-of-phase tapping conditions. Findings provide multiple levels of evidence that callosal anatomical and effective connectivity between the hand areas of the motor cortices play important roles in visually cued bimanual temporal coordination performance.

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Section: Visually Cued Bimanual Temporal Coordination (Vc-btc) Perforcontrasting

confidence: 48%

Callosal anatomical and effective connectivity between primary motor cortices predicts visually cued bimanual temporal coordination performance

et al. 2015

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“…The reliability of localizing the M1 region by nTMS has previously been shown to be of a value comparable with that of fMRI in healthy subjects. 13 In patients with brain tumors, fMRI might be less useful due to the patients' motor impairments (leading to stronger task-related head movement artifacts), reduced alertness/compliance, and potential changes in neurovascular coupling. 14 These effects are much less present in nTMS mapping performed in patients with brain tumors.…”

Section: Discussionmentioning

confidence: 99%

“…As in earlier studies, 13,17 motorevoked potentials were recorded of the abductor pollicis brevis muscle as the M1 hand representation, the plantar toe flexors representing the foot M1 region, and the anterior lateral tongue muscles as the M1 face representation. The "hotspot" was defined as the cortical stimulation site at which coil positioning, orientation, and tilt yielded the highest amplitude of the motor-evoked potentials.…”

Section: Ntms Motor Mappingmentioning

confidence: 99%

“…In 3 patients, the resting motor threshold of the foot representation area exceeded the maximum stimulator output intensity so that motor maps could not be obtained for this body part in these patients. 13 Likewise, detailed cartography of the cortical tongue representation could only be obtained in 83% of the patients (n ϭ 25). In the remaining patients (n ϭ 5), stimulation thresholds of facial nerve fibers were lower than those of the M1 representation, leading to false-positive motor-evoked potentials in the lateral tongue as evident by very short latencies (range, 3-6 ms).…”

Section: Ntms Motor Mappingmentioning

confidence: 99%

“…[10][11][12] This technique has a reliability similar to that of fMRI mapping, however, with less demand for the cooperation of patients who may have reduced alertness, compliance, and functional impairment such as those with brain tumors. 13,14 Another technique that adds information to structure-function relationships is diffusion imaging, especially DTI. 9,15,16 For example, DTI-based tractography has been developed to visualize the subcortical fiber tracts in individual subjects; this is especially useful in conditions in which the functional anatomy can be heavily distorted such as in patients with brain tumors.…”

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confidence: 99%

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Multimodal Imaging in Malignant Brain Tumors: Enhancing the Preoperative Risk Evaluation for Motor Deficits with a Combined Hybrid MRI-PET and Navigated Transcranial Magnetic Stimulation Approach

Neuschmelting

Lucas²,

Stoffels

et al. 2015

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Motor deficits in patients with brain tumors are caused mainly by irreversible infiltration of the motor network or by indirect mass effects; these deficits are potentially reversible on tumor removal. Here we used a novel multimodal imaging approach consisting of structural, functional, and metabolic neuroimaging to better distinguish these underlying causes in a preoperative setting and determine the predictive value of this approach.

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Symmetric corticospinal excitability and representation of vastus lateralis muscle in right‐handed healthy subjects

et al. 2014

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The purpose of this study was to determine the size and location of the representations of the anterior thigh muscles on the human motor cortex in the dominant and non-dominant hemispheres. Motor-evoked potentials (MEPs) induced by transcranial magnetic stimulation were recorded from the right and left vastus lateralis (rVL, lVL) muscles. A total of ten right-handed healthy volunteers participated in the study. In a single session experiment, we investigated VL muscle corticospinal excitability (motor threshold, MEP size, short interval intracortical inhibition, intracortical facilitation) and cortical representation (map area, volume, and location) in the dominant and non-dominant hemispheres. The motor threshold, MEPs, and intracortical excitability did not differ significantly between the hemispheres (P > 0.05). Furthermore, no difference between sides was found in the location of VL motor representation (mediolateral and anteroposterior axis) or in map area and volume (P > 0.05). Vastus lateralis muscle corticospinal excitability and cortical map were symmetrical in right-handed subjects. Future studies on patients with unilateral lower extremity injuries could examine side-to-side plastic reorganization in corticomotor output and map location in both hemispheres.

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Mapping the hand, foot and face representations in the primary motor cortex — Retest reliability of neuronavigated TMS versus functional MRI

Cited by 131 publications

References 91 publications

Callosal anatomical and effective connectivity between primary motor cortices predicts visually cued bimanual temporal coordination performance

Callosal anatomical and effective connectivity between primary motor cortices predicts visually cued bimanual temporal coordination performance

Multimodal Imaging in Malignant Brain Tumors: Enhancing the Preoperative Risk Evaluation for Motor Deficits with a Combined Hybrid MRI-PET and Navigated Transcranial Magnetic Stimulation Approach

Symmetric corticospinal excitability and representation of vastus lateralis muscle in right‐handed healthy subjects

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