Mapping the interaction site for β-arrestin-2 in the prokineticin 2 receptor

Lattanzi, R.; Casella, I.; Fullone, M.R.; Vincenzi, M.; Maftei, D.; Miele, R.

doi:10.1016/j.cellsig.2024.111175

Cellular Signalling

2024

DOI: 10.1016/j.cellsig.2024.111175

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Mapping the interaction site for β-arrestin-2 in the prokineticin 2 receptor

R. Lattanzi,

I. Casella,

M.R. Fullone

et al.

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2024

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Genetic Polymorphisms of Prokineticins and Prokineticin Receptors Associated with Human Disease

Lattanzi,

Miele

2024

Life

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Prokineticins (PKs) are low molecular weight proteins that exert their effects by binding to two seven-transmembrane G-protein-coupled receptors (prokineticin receptors, PKRs). The prokineticin system is an important player in the development of various diseases. Several polymorphisms that are associated with infertility, neuroendocrine disorders, Hirschsprung’s syndrome (HSCR), idiopathic central precocious puberty (CPP) and congenital disorders such as Kallmann syndrome (KS) have been described for both the PKs and PKR genes. The aim of this study is to summarize and describe the impact of PK/PKR polymorphisms on the pathogenesis and outcome of the above diseases, highlighting the PK system as a therapeutic target and diagnostic biomarker in pathological conditions.

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Genetic Polymorphisms of Prokineticins and Prokineticin Receptors Associated with Human Disease

Lattanzi,

Miele

2024

Life

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Mapping the interaction site for β-arrestin-2 in the prokineticin 2 receptor

Cited by 1 publication

References 31 publications

Genetic Polymorphisms of Prokineticins and Prokineticin Receptors Associated with Human Disease

Genetic Polymorphisms of Prokineticins and Prokineticin Receptors Associated with Human Disease

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