Marantic Endocarditis Associated with COVID-19: A Rare Case Report of a Potentially Deadly Disease

Chan, Kok Hoe; Joseph, Ormena; Ahmed, Eyad; Kommidi, Apoorva; Suleiman, Addi; Szabela, Maria; Slim, Jihad

doi:10.12890/2021_002409

Cited by 7 publications

(6 citation statements)

References 13 publications

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“…Notably, it has been suggested that COVID-19 infection can induce hypercoagulation, potentially contributing to pulmonary embolism, deep venous thrombosis, and the development of NBTE [7,8,[11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Non-bacterial Thrombotic Endocarditis (NBTE) in the Absence of Malignancy or Lupus Anticoagulant/Antiphospholipid Antibodies: A Case Report

Patrzałek,

Zawada,

Stolarski

et al. 2024

Cureus

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Non-bacterial thrombotic endocarditis (NBTE) is a very rare condition characterized by sterile thrombi formation on cardiac valves and is often associated with hypercoagulation states, such as malignancy and autoimmune disorders.We present the case of a 74-year-old patient admitted to the intensive care unit with acute respiratory failure, who had a history of COVID-19 infection five months prior to admission, despite having received certified vaccination. The patient developed NBTE involving the mitral valve, alongside acute respiratory distress syndrome (ARDS). In spite of the exclusion of cancer and systemic connective tissue disorders, the patient's condition rapidly deteriorated, leading to treatment-resistant multi-organ failure and demise, despite aggressive management, including anticoagulation therapy, mechanical ventilation, and renal replacement therapy. This case underscores the need for further research into the mechanisms underlying NBTE in the absence of traditional risk factors. Additionally, it highlights the importance of long-term anticoagulant therapy in NBTE management to mitigate the risk of embolic complications. Our case contributes to the growing body of literature identifying a subset of NBTE cancer-free patients with distinct characteristics, including those associated with current or past COVID-19 infection.

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Section: Discussionmentioning

confidence: 99%

Non-bacterial Thrombotic Endocarditis (NBTE) in the Absence of Malignancy or Lupus Anticoagulant/Antiphospholipid Antibodies: A Case Report

Patrzałek,

Zawada,

Stolarski

et al. 2024

Cureus

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“…Apixaban is not approved by FDA for arterial thrombosis/thromboembolic or left ventricular thrombus. Although apixaban was successfully used for the treatment of NBTE in a recent COVID-19 NBTE case report 13. Excision of the vegetation may have a role in some patients who do not have advanced malignancy 14.…”

Section: Discussionmentioning

confidence: 99%

“…Although apixaban was successfully used for the treatment of NBTE in a recent COVID-19 NBTE case report. 13 Excision of the vegetation may have a role in some patients who do not have advanced malignancy. 14 Lifelong anticoagulation is usually recommended in patients with cancer due to the reported recurrence of NBTE in patients taken off anticoagulation.…”

Section: Outcome and Follow-upmentioning

confidence: 99%

Non-bacterial thrombotic endocarditis in a patient with COVID

Ahmad,

Golemi,

Bedi

et al. 2023

BMJ Case Rep

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Non-bacterial thrombotic endocarditis is mainly associated with malignancies and rheumatological diseases. We report the case of mildly symptomatic COVID-19 infection with non-bacterial aortic valve vegetation complicated by transient ischemic attack (TIA) and pulmonary embolism during his hospitalisation. This case emphasised rare life-threatening complications from a hypercoagulable state related to COVID-19 infection. To the best of our knowledge, this is the third case report of non-bacterial endocarditis in a patient with COVID-19 patients as a potential rare complication of COVID-19.

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“…In the context of COVID-19 infection, it is important to be mindful of other differentials such as marantic endocarditis or non-bacterial thrombotic endocarditis. 11 COVID-19 infection causes a pro-inflammatory state with cytokine storm, which contributes to local tissue destruction and resultant thrombus vegetation formation on the disrupted areas. In the context of negative blood culture results, marantic endocarditis must be considered in a patient with COVID-19 infection as it is responsive to anticoagulants.…”

Section: Discussionmentioning

confidence: 99%