Marcadores de envolvimento sistêmico no lúpus eritematoso crônico discóide

Marçon, Carolina Reato; Moraes, Mariane Regina de; Lanzelotti, Soraia Maria; Simis, Débora Regina Cunha; Novaes, Gilberto Santos

doi:10.1590/s0482-50042004000500004

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…The homogeneous nuclear fluorescence pattern is primarily associated with systemic autoimmunity [ 47 ]. This pattern was observed in two patients who had a clinical condition of SLE: one of these patients exhibited the anti-SSA/Ro antibody; the other patient exhibited anti-Scl-70, anti-Smith, and anti-RNP/Sm; and the last two antibodies listed are markers for SLE [ 48 ]. Three of the five patients diagnosed with scleroderma exhibited anti-CENP-B and a centromere pattern (NC) in the ANA test.…”

Section: Discussionmentioning

confidence: 99%

Relationships among Antibodies against Extractable Nuclear Antigens, Antinuclear Antibodies, and Autoimmune Diseases in a Brazilian Public Hospital

Banhuk

Pahim

Jorge

et al. 2018

Autoimmune Diseases

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One characteristic of autoimmune diseases (ADs) is the production of autoantibodies for extractable nuclear autoantigens, which may aid in the discrimination of the different types of autoimmune diseases and is related to different antinuclear antibody (ANA) patterns. The present study verified the profile of patient samples tested for extractable nuclear antigens (ENA) antibodies in a public hospital and correlated the ENA results with ANA patterns and patient diagnoses. The study reviewed data in the medical records of patients who underwent anti-ENA tests at a public hospital in the West of the State of Paraná from February 2011 to January 2017. Patients were classified according to age, ethnicity, gender, anti-ENA test results, ANA results, and the presence or absence of AD. Thirty-six (20.9%) samples of the 172 anti-ENA tests were positive, seven (4.1%) samples were undetermined, and 129 (75%) exhibited negative results. The ANA reagent was found in 84.3% of the anti-ENA-positive samples. The anti-SSA/Ro autoantibody exhibited the highest frequency in the group, 41.7% (15/36). The most common pattern was nuclear fine speckled, which was found in 24.3% of the samples. The association results indicated a significant relationship between ANA titer and diagnosis in the anti-ENA- and ANA-positive patients. The anti-ENA-negative patients were diagnosed with an AD in 35% (45/129) of the cases, and 75% (27/36) of the anti-ENA-positive patients were diagnosed with an AD. Systemic lupus erythematosus and scleroderma were the most common pathologies in the antigen-positive patients. The anti-ENA test is a good marker to aid in the complex clinical diagnosis of patients with autoimmune diseases.

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Section: Discussionmentioning

confidence: 99%

Relationships among Antibodies against Extractable Nuclear Antigens, Antinuclear Antibodies, and Autoimmune Diseases in a Brazilian Public Hospital

Banhuk

Pahim

Jorge

et al. 2018

Autoimmune Diseases

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“…73,74 So another important characteristic marker of SLE is the production of anti-DNA antibodies that is directly associated with disease activity, being used by many studies as a parameter for diagnosis. 75,76 In this way, we performed an assay to detect these antibodies in our animals to verify the plausible interference of the exposure to PM2.5 in autoantibody production. We were expecting to obtain increased levels of anti-DNA antibodies.…”

Section: Analysis Of Anti-dna Antibodiesmentioning

confidence: 99%

Effect of chronic exposure to fine particulate matter on cardiac tissue of NZBWF1 mice

Waked

Rodrigues

Silva

et al. 2023

Int J Experimental Path

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Epidemiological and toxicological studies have shown that inhalation of particulate matter (PM) is associated with development of cardiovascular diseases. Long-term exposure to PM may increase the risk of cardiovascular events and reduce life expectancy. Systemic lupus erythematosus (SLE) is a chronic in ammatory disease with autoimmune nature, characterized by the production of autoantibodies that affects several organs, including the heart. Caused by several factors, air pollution, may appear as one of the most important points on the onset and development of SLE. This study aims to investigate whether exposure to air pollution promotes increased in ammation and cardiac remodeling in animals predisposed to SLE. Female mice of NZBWF1, were used in an environmental particle concentrator. Aspects related to cardiac remodeling, in ammation and apoptosis in myocardium were analyzed. Body weight gain, cardiac trophism by heart/body weight ratio, relative area of cardiomyocytes and brotic area of cardiac tissue were evaluated during exposure period. Animals exposed to PM2.5 showed increased area of cardiomyocytes, and area of brosis, in addition, we observed an increase of IL-1 and C3 in cardiac tissue, demonstrating increased in ammation. We suggest that air pollution is capable of promoting cardiac remodeling and increased in ammation in animals predisposed to SLE.

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“…Outro marcador importante característico do LES, é produção de anticorpos anti-DNA e está diretamente relacionado a atividade da doença, sendo utilizado por muitos estudos, como um parâmetro de confirmação da doença (Jesus et al, 2012;Marçon et al, 2004). Nesse sentido, realizamos um ensaio para detecção desses anticorpos nos animais lúpicos, visando verificar a possível interferência da exposição ao material particulado, na produção desse marcador.…”

Section: Discussionunclassified

Efeito da exposição crônica ao material particulado fino no tecido cardíaco de camundongos predispostos ao Lúpus Eritematoso Sistêmico

Waked¹

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mim durante o período do mestrado e por toda ajuda, força e atenção nos momentos de ansiedade. Obrigada por todos os ensinamentos, conselhos e oportunidades durante os últimos anos. Deixo aqui minha gratidão e admiração.Às minhas amigas e parceiras de laboratório, Thamires Moraes e Ana Clara Bastos, agradeço a amizade, companheirismo e apoio de vocês. Todos os cafés, conversas e desabafos deixaram essa caminhada mais leve.Aos demais colegas e colaboradores, Victor Yariwake, Gabriel Pereira, Felipe Pereira, Roberta Foster e Álvaro Pelegrin, obrigada por todos os momentos divertidos, experimentos e incentivos, em especial ao Victor por toda ajuda, correções e esclarecimentos durante esse estudo.Aos meus colegas de pós-graduação, Denival Junior, Aline Parletta, Tabatha Oliveira e Guilherme Lunardon, que mesmo à distância nunca deixaram de me apoiar, agradeço toda ajuda e amizade de vocês.A todos os funcionários do laboratório pelo auxílio e cuidado de sempre, e à Faculdade de medicina da Universidade de São Paulo (FMUSP) pela infraestrutura e apoio institucional.À Deus por toda graça, por me guiar e proteger em todos os momentos, e até aqui ter me sustentado.À toda minha família pelo apoio e acolhimento, em especial ao meu Pai Samir Waked, que sempre foi meu maior incentivador na carreira cientifica, à minha Mãe e Irmã, Graça Waked e Adila Waked, amo todos vocês! À Penelope, José, Julie, Sky e Milly por serem a minha válvula de escape e estarem comigo nos momentos mais difíceis.

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Marcadores de envolvimento sistêmico no lúpus eritematoso crônico discóide

Cited by 5 publications

References 16 publications

Relationships among Antibodies against Extractable Nuclear Antigens, Antinuclear Antibodies, and Autoimmune Diseases in a Brazilian Public Hospital

Relationships among Antibodies against Extractable Nuclear Antigens, Antinuclear Antibodies, and Autoimmune Diseases in a Brazilian Public Hospital

Effect of chronic exposure to fine particulate matter on cardiac tissue of NZBWF1 mice

Efeito da exposição crônica ao material particulado fino no tecido cardíaco de camundongos predispostos ao Lúpus Eritematoso Sistêmico

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