Marijuana and the Cannabinoids

ElSohly, Mahmoud A.

doi:10.1007/978-1-59259-947-9

Cited by 73 publications

(13 citation statements)

References 156 publications

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“…The cannabis belongs to the Canabinous family with a species called Cannabis sativa L. The female flower and the dried leaves of this plant are called marijuana and it has many cannabinoid compounds (1)(2). Hashish is a resin secretion of this plant, produced in its trichomes, and has a high content of delta-9-tetrahydrocannabinol (THC) (3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Effect of hydroalcoholic extract of Cannabis (Cannabis sativa L.) on morphology and the process of human adipose-drived mesenchymal stem cell growth

et al. 2018

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Background: Today, cannabis sativa L. is the most consuming drug trafficking plant in the world after nicotine and alcohol. Aims: Given the properties of cannabis and psychoactive compounds of this opiate drug, including hashish, as well as the importance of human adipose-derived mesenchymal stem cells in the restoration and regeneration of organs and its application in tissue transplantation and tissue engineering, the current paper investigates the effect of hashish (hydroalcoholic extract of cannabis) on the morphology and growth process of human adiposed-drived mesenchymal stem cells in vitro. Methods: Human adipose-drived mesenchymal stem cells were extracted from the abdominal fat by the enzyme digestion of the patient's abdominal region. MTT test was performed to determine the best concentration of cannabis extract. Cells were treated for seven days at 100 ng / ml and 1000 ng / ml, and propagation, growth and viability of the cells were evaluated. Results:The results show that cannabis extract reduces the proliferation of human adipose-drived mesenchymal stem cells as time-dependent. Also, the effect of cannabis extract on mesenchymal cells depends on concentrations. High concentrations have a greater negative effect on the growth of the cells. The results of this study showed that the morphology of human adipose-drived mesenchymal stem cells did not change after exposure to cannabis extract. Conclusion: Although in the first days, the growth process is elevated and the cells are in the euphoric phase, apoptosis increases with time as consumption increases due to toxicity. The effects of cannabis on fat cells indicate a decrease in the volume of adipose tissue and, consequently, in the consumer's slimming.

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Section: Introductionmentioning

confidence: 99%

Effect of hydroalcoholic extract of Cannabis (Cannabis sativa L.) on morphology and the process of human adipose-drived mesenchymal stem cell growth

et al. 2018

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“…The 1H 1 NMR spectra (500 MHz) and 13C NMR spectra (125.0 MHz) were recorded in CDCl 3 using AGILENT DD2 500 spectrometer. Chemical shifts are reported in  (ppm) values relative to TMS and 1 H NMR spectrum with signals was observed for the identification of aromatic and olefinic hydrogen atoms of cannabinoids (Brenneisen, 2007).…”

Section: Chemical Analysismentioning

confidence: 99%

“…The Cannabis plant and its products consist of an enormous variety of chemicals whereof some of the 483 compounds were identified and more than 60 cannabinoids were found unique to the genus, whereas the terpenes, with about 140 members forming the most abundant class, are widespread in the plant kingdom. The main biologically active cannabinoids are tetrahydrocannabinol, commonly referred to THC, known for its psychoactive properties and the nonpsychoactive cannabidiol (CBD), characteristic of fiber-type cannabis (Brenneisen, 2007). Cannabis legislation models include prohibition, legalization for medical purposes, decriminalization, and legalization of recreational use (Hilal et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Yielding Morphological Characteristics and Biochemical Analysis of “Karma lemon” Cannabis Producing Cannabinoids in Thessaloniki-Greece

Djamel¹,

Assaad²,

Wahab³

et al. 2020

JAS

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Cannabis has been widely used by humans over many centuries as a source of ﬁber, oil and for medicinal purposes. Its use was illicit in numerous countries, including Greece and Lebanon. “Karma Lemon”, one of the newest cannabis strain originated from Italy, is selected in this study to analyze its components using various techniques starting from the extraction, isolation and identification of cannabinoids using separatory compounds and NMR techniques as well as the main important morphological traits of this strain to be harvested at an appropriate time for medicinal uses in Greece and later on, in Lebanon. Thirty different samples were selected from the field of respected “Hemp Way Company” in Thessaloniki and studied for morphological traits. These were related to the length of the plant at harvest time (1.809 m) needed for the use of combines and the weight of inflorescence (213.5 g fresh and 40.8 g dry) for oil or seed production. Three samples of Karma Lemon cannabis strain inflorescence were analyzed at the Laboratory of Pharmacognosy, School of Pharmacy, in the Aristotle University of Thessaloniki in Greece, after proper extraction and isolation using ethanol and other separation compounds. TLC and NMR techniques were used to visualize and identify cannabinoids present after isolation. Cannabinoid acids, CBG, CBN, THC, CBD and other cannabinoids were identified and isolated.

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“…A wide variety of chemically active compounds (such as cannabinoids, terpenoids, flavonoids, and alkaloids) are biosynthesized in cannabis (Andre et al, 2016). Out of all these different compounds, the cannabinoids, which are biosynthesized in the glandular trichomes of the plant, are most prominently studied substances of cannabis (Taura et al, 2007;Brenneisen, 2007). Even though more than 100 cannabinoids have been identified, Δ-9-tetrahydrocannabinol (Δ9 -THC) and cannabidiol (CBD) are widely accepted as the most important ones due to their pharmacologic properties (Sikora et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

THC Yield and Greenhouse Cover Materials: Optimizing the Profit of Medical Cannabis

et al. 2022

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Even though Delta-9-tetrahydrocannabinol (THC) is a psychoactive substance, studies indicate that it has therapeutic properties. Moreover, the modification in Greece legislation regarding the legalization of cannabis has resulted in new business opportunities for medical-cannabis related companies. This study aimed to evaluate whether different greenhouse cover materials affect THC yield and propose a business plan for any potential medical-cannabis related company in Greece. A greenhouse experiment was conducted in order to evaluate the effect of different plastic cover films in greenhouses for the cultivation of Cannabis sativa. Furthermore, the economic viability of a potential medical-cannabis related business in Greece was evaluated based upon a financial analysis. Yields were increased in greenhouses with double plastic cover materials (compared to the control). According to the results of our comparative economic analysis the production of medical cannabis in greenhouses constructed with double layered cover materials would significantly increase profits. Finally, greenhouse medical-cannabis production is much promising in Greece. Nevertheless, the use of appropriate greenhouse cover materials should be considered as they affect THC yield and therefore, the profit of the company.

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Marijuana and the Cannabinoids

Cited by 73 publications

References 156 publications

Effect of hydroalcoholic extract of Cannabis (Cannabis sativa L.) on morphology and the process of human adipose-drived mesenchymal stem cell growth

Effect of hydroalcoholic extract of Cannabis (Cannabis sativa L.) on morphology and the process of human adipose-drived mesenchymal stem cell growth

Yielding Morphological Characteristics and Biochemical Analysis of “Karma lemon” Cannabis Producing Cannabinoids in Thessaloniki-Greece

THC Yield and Greenhouse Cover Materials: Optimizing the Profit of Medical Cannabis

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