Marine haloperoxidases

Butler, Alison; Walker, Jerrylaine V.

doi:10.1021/cr00021a014

Cited by 652 publications

(386 citation statements)

References 26 publications

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“…For these enzymes that are inhibited by vanadate, the mechanism is through trapping the vanadate at the phosphate site accompanied by slow release, assuring reduced catalytic turnover and inhibition of the enzyme activity. [1][2][3][4][5][6][7][8][9]11 The SR Ca 2+ -ATPase catalysis proceeds through a noncovalent phosphoenzyme intermediate as has been observed for other ATPases and phosphorylases and subsequent formation of a phosphorylenzyme intermediate during ATP hydrolysis. 10 In the absence of ATP and calcium, for this ATPase vanadate is proposed to bind in the vicinity of the aspartyl phosphate acceptor so as to block the active site and thus prevent phosphoenzyme intermediate formation, ultimately trapping the enzyme in the E2 conformation.…”

Section: Resultsmentioning

confidence: 99%

Sarcoplasmic Reticulum Calcium ATPase Is Inhibited by Organic Vanadium Coordination Compounds: Pyridine-2,6-dicarboxylatodioxovanadium(V), BMOV, and an Amavadine Analogue

et al. 2008

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The general affinity of the sarcoplasmic reticulum (SR) Ca 2+ -ATPase was examined for three different classes of vanadium coordination complexes including a vanadium(V) compound, pyridine-2,6-dicarboxylatodioxovanadium(V) (PDC-V(V)), and two vanadium(IV) compounds, bis(maltolato)oxovanadium(IV) (BMOV), and an analogue of amavadine, bis(N-hydroxylamidoiminodiacetato)vanadium(IV) (HAIDA-V(IV)). The ability of vanadate to act either as a phosphate analogue or as a transition-state analogue with enzymes' catalysis phosphoryl group transfer suggests that vanadium coordination compounds may reveal mechanistic preferences in these classes of enzymes. Two of these compounds investigated, PDC-V(V) and BMOV, were hydrolytically and oxidatively reactive at neutral pH, and one, HAIDA-V(IV), does not hydrolyze, oxidize, or otherwise decompose to a measurable extent during the enzyme assay. The SR Ca 2+ -ATPase was inhibited by all three of these complexes. The relative order of inhibition was PDC-V(V) > BMOV > vanadate > HAIDA-V(IV), and the IC 50 values were 25, 40, 80, and 325 µM, respectively. Because the observed inhibition is more potent for PDC-V(V) and BMOV than that of oxovanadates, the inhibition cannot be explained by oxovanadate formation during enzyme assays. Furthermore, the hydrolytically and redox stable amavadine analogue HAIDA-V(IV) inhibited the Ca 2+ -ATPase less than oxovanadates. To gauge the importance of the lipid environment, studies of oxidized BMOV in microemulsions were performed and showed that this system remained in the aqueous pool even though PDC-V(V) is able to penetrate lipid interfaces. These findings suggest that the hydrolytic properties of these complexes may be important in the inhibition of the calcium pump. Our results show that two simple coordination complexes with known insulin enhancing effects can invoke a response in calcium homeostasis and the regulation of muscle contraction through the SR Ca 2+ -ATPase.

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Section: Resultsmentioning

confidence: 99%

Sarcoplasmic Reticulum Calcium ATPase Is Inhibited by Organic Vanadium Coordination Compounds: Pyridine-2,6-dicarboxylatodioxovanadium(V), BMOV, and an Amavadine Analogue

et al. 2008

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“…[1][2][3][4][5][6][7] In recent years, the interest to the chemistry of oxovanadates has grown considerably. 8 The increasing interest is mainly owing to the role of vanadium in several biological processes such as the regulation of glucose level in the blood of diabetic animals and patients.…”

Section: Introductionmentioning

confidence: 99%

“…8 The increasing interest is mainly owing to the role of vanadium in several biological processes such as the regulation of glucose level in the blood of diabetic animals and patients. 3,4,[9][10][11][12][13][14][15][16][17] Moreover, decavanadate and oxovanadates have many biological activities and been successfully used for the comprehension of several biochemical processes. 18 Other interest for vanadium oxides is sourced from their potential uses as secondary cathode materials, both catalysis and electronics.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Crystal Structure of a Novel Decavanadate Salt, [V0.50(H2O)5]2[H2(V10O28)]·4(H2O)

Bíçer

Dege

Coşkun

2017

J. Chil. Chem. Soc.

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A novel decavanadate salt, [V 0.50 ( At this dimer moiety, it has been thought that the oxygen atoms of two water molecules form the bridges between two V(IV) center ions. The presence of high spin V(IV) (I = 7/2) in the compound was verified by EPR measurements. In addition, decavanadate unit gave a shoulder at about 400 nm on the UV-Vis. spectrum of the compound. Moreover, at the FT-IR spectrum, the symmetric and asymmetric stretching vibrations of the bridging V-O-V units were observed. On the cyclic voltammogram of the compound, two reduction peaks (V(V)-V(IV) and V(IV)-V(II) reduction steps, respectively) at −1.03 and −1.35 V were observed at the cathodic scan; however, one oxidation peak (V(II)-V(III) oxidation step) at −1.22 V showed at the anodic scan. NMR results also support that the synthesized salt includes the coordinated water molecules and hydroxo groups.

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“…и др.) [26], одного вида гриба (Curvularia inaequalis (Shear) Boedijn 1907) [27] и одного вида лишайника [28]. Ещё один класс ферментов, в активный центр которых входит ванадий, -ванадий-зависимые альтернативные нитрогеназы, выделенные из двух видов азотфиксирующих бактерий, Azotobacter chroococcum и A. vinelandii Lipman 1903 [29].…”

Section: ванадий в биологических системахunclassified

The vanadium compounds: chemistry, synthesys, insulinomimetic properties

et al. 2014

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The review considers the biological role of vanadium, its participation in various processes in humans and other mammals, and the anti-diabetic effect of its compounds. Vanadium salts have persistent hypoglycemic and antihyperlipidemic effects and reduce the probability of secondary complications in animals with experimental diabetes. The review contains a detailed description of all major synthesized vanadium complexes having antidiabetic activity. Currently, vanadium complexes with organic ligands are more effective and safer than the inorganic salts. Despite the proven efficacy of these compounds as the anti-diabetic agents in animal models, only one organic complex of vanadium is currently under the second phase of clinical trials. All of the considered data suggest that vanadium compound are a new promising class of drugs in modern pharmacotherapy of diabetes.

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Marine haloperoxidases

Cited by 652 publications

References 26 publications

Sarcoplasmic Reticulum Calcium ATPase Is Inhibited by Organic Vanadium Coordination Compounds: Pyridine-2,6-dicarboxylatodioxovanadium(V), BMOV, and an Amavadine Analogue

Sarcoplasmic Reticulum Calcium ATPase Is Inhibited by Organic Vanadium Coordination Compounds: Pyridine-2,6-dicarboxylatodioxovanadium(V), BMOV, and an Amavadine Analogue

Synthesis, Characterization and Crystal Structure of a Novel Decavanadate Salt, [V0.50(H2O)5]2[H2(V10O28)]·4(H2O)

The vanadium compounds: chemistry, synthesys, insulinomimetic properties

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