Anthropogenic marine debris (AMD) represent a global threat for aquatic environments. It is important to locate and monitor the distribution and presence of macroplastics along beaches to prevent degradation into microplastics (MP), which are potentially more harmful and more difficult to remove. UAV imaging represents a quick method for acquiring pictures with a ground spatial resolution of a few centimeters. In this work, we investigate strategies for AMD mapping on beaches with different ground resolutions and with elevation and multispectral data in support of RGB orthomosaics. Operators with varying levels of expertise and knowledge of the coastal environment map the AMD on four to five transects manually, using a range of photogrammetric tools. The initial survey was repeated after one year; in both surveys, beach litter was collected and further analyzed in the laboratory. Operators assign three levels of confidence when recognizing and describing AMD. Preliminary validation of results shows that items identified with high confidence were almost always classified properly. Approaching the detected items in terms of surface instead of a simple count increased the percentage of mapped litter significantly when compared to those collected. Multispectral data in near-infrared (NIR) wavelengths and digital surface models (DSMs) did not significantly improve the efficiency of manual mapping, even if vegetation features were removed using NDVI maps. In conclusion, this research shows that a good solution for performing beach AMD mapping can be represented by using RGB imagery with a spatial resolution of about 200 pix/m for detecting macroplastics and, in particular, focusing on the largest items. From the point of view of assessing and monitoring potential sources of MP, this approach is not only feasible but also quick, practical, and sustainable.