Marine resources effective in controlling and treating diabetes and its associated complications

Nasab, Soudeh Bahramian; Homaei, Ahmad; Pletschke, Brett I.; Salinas-Salazar, Carmen; Castillo-Zacarías, Carlos; Parra‐Saldívar, Roberto

doi:10.1016/j.procbio.2020.01.024

Cited by 31 publications

(15 citation statements)

References 213 publications

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“…Strategies in the management of diabetes include the inhibition of α-amylase, α-glucosidase, glucosidase, glycogen synthase kinase 3β (GSK-3β), lipase, aldose reductase, protein tyrosine phosphatases 1B (PTP1B), and dipeptidyl peptidase IV (DPP-4). Moreover, the prevention of insulin resistance, increase in the phosphorylation of AMP-activated protein kinase (AMPK), regulation of glucose and lipid metabolism, reduction in oxidative stress, and protection of β-pancreatic cells are other approaches to control hyperglycemia ( 96 ). In recent years, researchers have considered the bioactive compounds from shellfish polysaccharides in the development of new functional foods.…”

Section: Biological Activity Of Shellfish Polysaccharidesmentioning

confidence: 99%

A review on shellfish polysaccharides: Extraction, characterization and amelioration of metabolic syndrome

et al. 2022

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Shellfish are diverse, widely distributed organisms that are a rich source of biological resources. Polysaccharides are an important components in shellfish, hence a great deal of attention has been directed at isolation and characterization of shellfish polysaccharides because of their numerous health benefits. Differences in shellfish species, habits, and environment result in the diversity of the structure and composition of polysaccharides. Thus, shellfish polysaccharides possess special biological activities. Studies have shown that shellfish polysaccharides exert biological activities, including antioxidant, antitumor, immune-regulation, hypolipidemic, antihypertensive, and antihyperglycemic effects, and are widely used in cosmetics, health products, and medicine. This review spotlights the extraction and purification methods of shellfish polysaccharides and analyses their structures, biological activities and conformational relationships; discusses the regulatory mechanism of shellfish polysaccharides on hyperlipidemia, hypertension, and hyperglycemia caused by lipid metabolism disorders; and summarizes its alleviation of lipid metabolism-related diseases. This review provides a reference for the in-depth development and utilization of shellfish polysaccharides as a functional food to regulate lipid metabolism-related diseases. To achieve high value utilization of marine shellfish resources while actively promoting the development of marine biological industry and health industry.

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Section: Biological Activity Of Shellfish Polysaccharidesmentioning

confidence: 99%

A review on shellfish polysaccharides: Extraction, characterization and amelioration of metabolic syndrome

et al. 2022

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“…Among marine algae, the brown algae exert effective biologic activities including antidiabetic, anti-inflammatory, cytotoxic, and antioxidant activity, and produce the most important secondary bioactive metabolites such as chlorotanins, fucosterols, fucoidan, alginic acids, and phycoxanthin [ 25 ]. Considering that there is also a desire for safe and effective antidiabetic medicinal products for diabetes management, the use of algae-derived compounds can be an asset in the treatment of this pathology.…”

Section: From Basic Research To Translational Nanomedicine: Advancements and Prospectsmentioning

confidence: 99%

“…Marine algae are classified into three major distinct classes based on the presence of specific pigments. Therefore, algae can be brown (Phaeophyta/Phaeophyceae, such as Sargassum polycystum , Padina pavonica , and Cystophora moniliformis ); blue-green (Cyanophyta/Cyanophyceae, such as Spirulina platensis , Chlorococcum humicola , and Chlorella vulgaris ); green (Chlorophyta/Chlorophyceae, such as Chlamydomonas reinhardtii , Ulva fasciata , and Gracilaria edulis ); or red (Rhodophyta/Rhodophyceae, such as Palmaria decipiens , Gelidiella acerosa , and Gracilaria corticata ) [ 3 , 7 , 19 , 21 , 23 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

“…Among all algal-mediated NPs, metallic NPs (MNPs) are more potent due to their unique optical and electronic properties and biocompatible nature, which has increased their usage in the biomedical field [ 7 , 21 , 23 , 37 ]. Their inert nature, low toxicity, and small size (increasing their cell penetration) make them potent candidates for safer and targeted theranostic applications (e.g., drug/gene delivery, gene delivery, immunoassays, tissue repair, laser-assisted therapy (e.g., photodynamic therapy (PDT) and photothermal therapy (PTT)), and/or imaging modalities (e.g., magnetic resonance imaging [MRI], positron emission tomography (PET), biosensing, and cancer chemotherapy)) [ 1 , 7 , 15 , 21 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Marine Algae-Derived Bioactive Compounds: A New Wave of Nanodrugs?

Wijesinghe²,

et al. 2021

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Marine algae are rich in bioactive nutraceuticals (e.g., carbohydrates, proteins, minerals, fatty acids, antioxidants, and pigments). Biotic (e.g., plants, microorganisms) and abiotic factors (e.g., temperature, pH, salinity, light intensity) contribute to the production of primary and secondary metabolites by algae. Easy, profitable, and sustainable recovery methods include novel solid-liquid and liquid-liquid extraction techniques (e.g., supercritical, high pressure, microwave, ultrasound, enzymatic). The spectacular findings of algal-mediated synthesis of nanotheranostics has attracted further interest because of the availability of microalgae-based natural bioactive therapeutic compounds and the cost-effective commercialization of stable microalgal drugs. Algal extracts can serve as stabilizing/capping and reducing agents for the synthesis of thermodynamically stable nanoparticles (NPs). Different types of nanotherapeutics have been synthesized using physical, chemical, and biological methods. Marine algae are a fascinating source of lead theranostics compounds, and the development of nanotheranostics has been linked to enhanced drug efficacy and safety. Indeed, algae are remarkable nanobiofactories, and their pragmatic properties reside in their (i) ease of handling; (ii) capacity to absorb/accumulate inorganic metallic ions; (iii) cost-effectiveness; and (iv) capacity of eco-friendly, rapid, and healthier synthesis of NPs. Preclinical and clinical trials shall enable to really define effective algal-based nanotherapies. This review aims to provide an overview of the main algal compounds that are nutraceuticals and that can be extracted and purified for nanotheranostic purposes.

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“…Due to its peculiar environment and rich biodiversity, the marine resource is a treasure box for isolating novel bioactive compounds. Over the years, antibacterial [ 19 , 20 , 21 ], antifungal [ 22 , 23 ], antiviral [ 24 , 25 , 26 ], anthelminths [ 27 , 28 ], antiprotozoan [ 29 , 30 , 31 ], antitumor [ 32 , 33 ], anticancer [ 34 , 35 , 36 ], anti-inflammatory [ 37 , 38 ], antioxidant [ 39 , 40 ], antiaging [ 41 , 42 ] and antidiabetics [ 43 , 44 , 45 ] compounds have been isolated from different marine organisms.…”

Section: Introductionmentioning

confidence: 99%

Marine Bioactive Compounds against Aspergillus fumigatus: Challenges and Future Prospects

et al. 2020

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With the mortality rate of invasive aspergillosis caused by Aspergillus fumigatus reaching almost 100% among some groups of patients, and with the rapidly increasing resistance of A. fumigatus to available antifungal drugs, new antifungal agents have never been more desirable than now. Numerous bioactive compounds were isolated and characterized from marine resources. However, only a few exhibited a potent activity against A. fumigatus when compared to the multitude that did against some other pathogens. Here, we review the marine bioactive compounds that display a bioactivity against A. fumigatus. The challenges hampering the discovery of antifungal agents from this rich habitat are also critically analyzed. Further, we propose strategies that could speed up an efficient discovery and broaden the dimensions of screening in order to obtain promising in vivo antifungal agents with new modes of action.

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Marine resources effective in controlling and treating diabetes and its associated complications

Cited by 31 publications

References 213 publications

A review on shellfish polysaccharides: Extraction, characterization and amelioration of metabolic syndrome

A review on shellfish polysaccharides: Extraction, characterization and amelioration of metabolic syndrome

Marine Algae-Derived Bioactive Compounds: A New Wave of Nanodrugs?

Marine Bioactive Compounds against Aspergillus fumigatus: Challenges and Future Prospects

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