Marked brain asymmetry with intact cognitive functioning in idiopathic Parkinson’s disease: a longitudinal analysis

Tanner, Jared J.; Levy, Shellie-Anne; Schwab, Nadine A.; Hizel, Loren P.; Nguyen, Peter; Okun, Michael S.; Price, Catherine C.

doi:10.1080/13854046.2016.1251973

Cited by 10 publications

(6 citation statements)

References 85 publications

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“…The final sample included 40 people with idiopathic PD and 40 non-PD peers. Diffusion and gray matter structural data from some of these participants have also been seen in recent publications (Crowley et al, 2017 ; Price et al, 2016 ; Schwab et al, 2015 ; Tanner, Levy, et al, 2017 ; Tanner et al, 2015 ; Tanner, McFarland, et al, 2017 ).…”

Section: Methodssupporting

confidence: 53%

Cognition and connectomes in nondementia idiopathic Parkinson’s disease

Colon-Perez

Tanner

Couret

et al. 2018

Network Neuroscience

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In this study, we investigate the organization of the structural connectome in cognitively well participants with Parkinson’s disease (PD-Well; n = 31) and a subgroup of participants with Parkinson’s disease who have amnestic disturbances (PD-MI; n = 9). We explore correlations between connectome topology and vulnerable cognitive domains in Parkinson’s disease relative to non-Parkinson’s disease peers (control, n = 40). Diffusion-weighted MRI data and deterministic tractography were used to generate connectomes. Connectome topological indices under study included weighted indices of node strength, path length, clustering coefficient, and small-worldness. Relative to controls, node strength was reduced 4.99% for PD-Well (p = 0.041) and 13.2% for PD-MI (p = 0.004). We found bilateral differences in the node strength between PD-MI and controls for inferior parietal, caudal middle frontal, posterior cingulate, precentral, and rostral middle frontal. Correlations between connectome and cognitive domains of interest showed that topological indices of global connectivity negatively associated with working memory and displayed more and larger negative correlations with neuropsychological indices of memory in PD-MI than in PD-Well and controls. These findings suggest that indices of network connectivity are reduced in PD-MI relative to PD-Well and control participants.

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Section: Methodssupporting

confidence: 53%

Cognition and connectomes in nondementia idiopathic Parkinson’s disease

Colon-Perez

Tanner

Couret

et al. 2018

Network Neuroscience

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“…In fact, asymmetric differences in psychotic symptoms and cognitive impairment, such as poor verbal fluency, object naming, and verbal memory, have been seen to predominate in those with right side motor symptoms whereas deficiencies in prosodic emotion recognition have been associated with left side motor symptoms. 105 , 106 Interestingly, the degree of asymmetry and side of symptom onset are associated with differing rate of disease progression, severity of symptoms and disease duration 93 , 107–109 ; thus, side of symptom onset provides relevant information for disease prognosis. Despite this unilateral asymmetry being well documented, its origin and role in disease pathology is still not well understood ( Table 1 ).…”

Section: Asymmetry In Neurodegenerative Diseasesmentioning

confidence: 99%

The enigma and implications of brain hemispheric asymmetry in neurodegenerative diseases

Lubben

Ensink

Coetzee

et al. 2021

Brain Communications

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The lateralization of the human brain may provide clues into the pathogenesis and progression of neurodegenerative diseases. Though differing in their presentation and underlying pathologies, neurodegenerative diseases are all devastating and share an intriguing theme of asymmetrical pathology and clinical symptoms. Parkinson’s disease, with its distinctive onset of motor symptoms on one side of the body, stands out in this regard, but a review of the literature reveals asymmetries in several other neurodegenerative diseases. Here we review the lateralization of the structure and function of the healthy human brain and the common genetic and epigenetic patterns contributing to the development of asymmetry in health and disease. We specifically examine the role of asymmetry in Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and multiple sclerosis, and interrogate whether these imbalances may reveal meaningful clues about the origins of these diseases. We also propose several hypotheses for how lateralization may contribute to the distinctive and enigmatic features of asymmetry in neurodegenerative diseases, suggesting a role for asymmetry in the choroid plexus, neurochemistry, protein distribution, brain connectivity, and the vagus nerve. Finally, we suggest how future studies may reveal novel insights into these diseases through the lens of asymmetry.

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“…Idiopathic PD generally presents, at initial phase, as an asymmetric clinical syndrome with right or left predominance, that correlates with neuronal loss in the deep gray matter of the contralateral hemisphere (Kempster et al, 1989 ; Lee et al, 2014 ; Tanner et al, 2017 ), although not systematically (Nemmi et al, 2015 ). Only a few studies looked specifically for the existence of structural cortical asymmetries in PD, suggesting that atrophy could start on one side (Zarei et al, 2013 ), and then extend to the other (Pereira et al, 2014 ; Tanner et al, 2017 ). Although the evidence of structural asymmetries extending to the cortical regions is for now weak, right-sided (RPD) and left-sided PD (LPD) are thought to have different cognitive profiles, with the former presenting dysfunction in language and verbal memory and the latter in spatial attention (see Verreyt et al, 2011 for a review).…”

Section: Introductionmentioning

confidence: 99%

Selection Processing in Noun and Verb Production in Left- and Right-Sided Parkinson's Disease Patients

et al. 2018

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Verbs are more difficult to produce than nouns. Thus, if executive resources are reduced as in Parkinson's disease (PD), verbs are penalized compared to nouns. However, in an experimental condition in which it is the noun that must be selected from a larger number of alternatives compared to the verb, it is the noun production that becomes slower and more prone to errors. Indeed, patients are slower and less accurate than normal subjects when required to produce nouns from verbs (VN) in a morphology derivation tasks (e.g., “osservazione” from “osservare”) [“observation” from “observe”] than verbs from nouns in a morphology generation task, in which only a verb can be generated from the noun (NV) (e.g., “fallire” from “fallimento”) [“to fail” from “failure”]. In the Italian language morphology, in fact, generation and derivation tasks differ in the number of lexical entries among which the response must be selected. The left Inferior Frontal Gyrus (IFG) has been demonstrated to be involved in selection processes. In the present study, we explored if the ability to select words is related to the cortical thickness of the left IFG. Twelve right-sided PD with nigrostriatal hypofunctionality in the left hemisphere (RPD-LH), 9 left-sided PD with nigrostriatal hypofunctionality in the right hemisphere (LPD-RH) and 19 healthy controls (HC) took part in the study. NV and VN production tasks were administered; accuracy and reaction times (RTs) were collected. All 40 subjects received a structural MRI examination. Cortical thickness of the IFG and volumetric measurements for subcortical regions, thought to support selection processes, were computed using FreeSurfer. In VN derivation tasks RPD-LH patients were less accurate than LPD-RH patients (accuracy: 66% vs. 77%). No difference emerged among the three groups in RTs. Task accuracy/RTs and IFG thickness showed a significant correlation only in RPD-LH. Not only nouns (as expected) but also verbs were correlated with cortical thickness. This suggests that the linguistic nature of the stimuli along with executive resources are both relevant during word selection processes. Our data confirm that executive resources and language interact in the left IFG in word production tasks.

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Marked brain asymmetry with intact cognitive functioning in idiopathic Parkinson’s disease: a longitudinal analysis

Cited by 10 publications

References 85 publications

Cognition and connectomes in nondementia idiopathic Parkinson’s disease

Cognition and connectomes in nondementia idiopathic Parkinson’s disease

The enigma and implications of brain hemispheric asymmetry in neurodegenerative diseases

Selection Processing in Noun and Verb Production in Left- and Right-Sided Parkinson's Disease Patients

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