Marked central canal T2-hyperintensity in MOGAD myelitis and comparison to NMOSD and MS

Webb, Lauren M.; Cacciaguerra, Laura; Krecke, Karl N.; Chen, John J.; Sechi, Elia; Redenbaugh, Vyanka; Dubey, Divyanshu; Pittock, Sean J.; Flanagan, Eoin P.

doi:10.1016/j.jns.2023.120687

Cited by 5 publications

(1 citation statement)

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“…A diffuse signal abnormality within the entire cord gray matter in the axial plane, anterior and posterior horns, is a feature of MOG-associated disorders myelopathy (the H sign) 41 . A marked T2 hyperintensity involving the cord's central canal is a frequent MRI feature of NMO and MOG-associated disorders 42 . Selective signal abnormality in T1-weighted images with gadolinium in the cord's posterior and lateral white matter tracts (the trident sign), suggests sarcoidosis-associated myelopathy 43 .…”

Section: Diagnostic Neuroimaging In the Evaluation Of Myelopathymentioning

confidence: 99%

Clinical Approach to Myelopathy Diagnosis

Pardo

2024

CONTINUUM: Lifelong Learning in Neurology

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OBJECTIVE This article describes an integrative strategy to evaluate patients with suspected myelopathy, provides advice on diagnostic approach, and outlines the framework for the etiologic diagnosis of myelopathies. LATEST DEVELOPMENTS Advances in diagnostic neuroimaging techniques of the spinal cord and improved understanding of the immune pathogenic mechanisms associated with spinal cord disorders have expanded the knowledge of inflammatory and noninflammatory myelopathies. The discovery of biomarkers of disease, such as anti–aquaporin 4 and anti–myelin oligodendrocyte glycoprotein antibodies involved in myelitis and other immune-related mechanisms, the emergence and identification of infectious disorders that target the spinal cord, and better recognition of myelopathies associated with vascular pathologies have expanded our knowledge about the broad clinical spectrum of myelopathies. ESSENTIAL POINTS Myelopathies include a group of inflammatory and noninflammatory disorders of the spinal cord that exhibit a wide variety of motor, sensory, gait, and sensory disturbances and produce major neurologic disability. Both inflammatory and noninflammatory myelopathies comprise a broad spectrum of pathophysiologic mechanisms and etiologic factors that lead to specific clinical features and presentations. Knowledge of the clinical variety of myelopathies and understanding of strategies for the precise diagnosis, identification of etiologic factors, and implementation of therapies can help improve outcomes.

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Section: Diagnostic Neuroimaging In the Evaluation Of Myelopathymentioning

confidence: 99%